Pathogenetic Evaluation of Dysfunction in the Erythron System of Experimental Animals during Modeling of Iron Deficiency Anemia in the Gestation Period

Abstract

We studied the dynamics of erythropoiesis in CBA mice during gestation against the background of treatment with iron-binding drug. The mechanisms of suppression of the bone marrow erythroid stem were evaluated. Administration of deferoxamine in a dose of 1 g/kg induced hypoplasia of the erythroid hemopoietic lineage. Suppression of bone marrow erythropoiesis manifested in a decrease of hemoglobin concentration and counts of reticulocytes, erythrocytes, and erythrokaryocytes. These changes were accompanied by a decrease in functional activity of erythropoietic precursors and secretion of erythropoietically active humoral factors by bone marrow myelokaryocytes. These data indicate that deferoxamine can be used for modeling of iron defi ciency anemia in pregnancy.

Aplastic anemia during pregnancy: a review of obstetric and anesthetic considerations

“… 47 Zhdanov et al demonstrated enhanced proliferative activity of erythroid precursors in bone marrow that was increased by concomitant administration of iron. 48 According to one theory, a population of primitive CD34 + progenitors responsible for cellular proliferation and regeneration is produced in maternal bone marrow in response to interaction with umbilical cord blood cells via immunologic signals. 49 Pregnancy is also sometimes accompanied by gestational thrombocytopenia and relative leukocytosis.…”