Pathogenetic aspects of premature ovarian failure

Adamyan, L.V.; Sibirskaya, E. V.; Shcherina, A.V.

doi:10.17116/repro2021270116

Cited by 4 publications

(1 citation statement)

References 22 publications

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“…При отриманні Р, що дорівнює 0,33 та менше, діагностують передчасне виснаження яєчників. Запропонований коефіцієнт дозволить репродуктологам своєчасно рекомендувати певній категорії жінок (віком до 30 років з відсутністю вказівок на раніше перенесене оперативне втручання на яєчниках) з коефіцієнтом Р нижче 0,33 відмовитись від засобів контрацепції для найшвидшої реалізації природного зачаття [1].…”

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DIFFERENTIAL APPROACHES TO DIAGNOSTIC AND POSSIBLE REHABILITATION OF PATIENTS WITH PREMATURE OVARIAN FAILURE (clinical lecture)

DUBOSSARSKA¹

2022

AAGU

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Premature ovarian failure (POF) –pathological condition characterized by amenorrhea, infertility, symptoms of hypoestrogyny on the background of increased levels of gonadotropins (in women under 40 years. To fill the deficit of sex hormones in the POF is the most rational to apply traditional hormone replacement therapy in cyclic mode. The innovative method for the treatment of this category of patients is based on the use of dehydroepiandrosterone.

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DIFFERENTIAL APPROACHES TO DIAGNOSTIC AND POSSIBLE REHABILITATION OF PATIENTS WITH PREMATURE OVARIAN FAILURE (clinical lecture)

DUBOSSARSKA¹

2022

AAGU

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Genetic aspects of POI and «poor response»: a modern view of the problem

Adamyan,

Kuznetsova,

Pavlova

et al. 2023

Probl. reprod.

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Coenzyme Q10 and embryonic development: a potential role in reproductive medicine

Khamadyanova,

Mannanov,

Smakova

et al. 2024

Akušerstvo, ginekologiâ i reprodukciâ

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Maternal mitochondria provide energy to the embryo through oxidative phosphorylation before blastocyst implantation, where intracellular energy is mainly supplied by glycolysis. Thus, it is obvious that mitochondria play a crucial role in providing energy for embryogenesis. Coenzyme Q10 (CoQ10) is a powerful endogenous membrane-localized antioxidant that protects circulating lipoproteins from lipid peroxidation. The results of several recent clinical studies have shown that exogenous CoQ10 supplements exert antioxidant effects and may be a potential therapy to reduce oxidative stress. CoQ10 deficiency increases the risk of impaired embryonic development; however, this relationship remains unclear. Given that the level of CoQ10 is influenced by enzymes involved in its synthesis, it is difficult to say whether the disorders are caused by CoQ10 deficiency or directly result from defects in the target gene. It has been shown that in the absence of CoQ10, ATP synthesis decreases in parallel with increased oxidative stress in mitochondria, two biological events which affect embryonic development. The review highlights the importance of CoQ10 as an antioxidant for improving egg quality, and also emphasizes its key role in embryonic development. It is necessary to conduct further studies aimed at studying metabolic changes during embryogenesis, as well as the mechanism of CoQ10 effects.

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Pathogenetic aspects of premature ovarian failure

Cited by 4 publications

References 22 publications

DIFFERENTIAL APPROACHES TO DIAGNOSTIC AND POSSIBLE REHABILITATION OF PATIENTS WITH PREMATURE OVARIAN FAILURE (clinical lecture)

DIFFERENTIAL APPROACHES TO DIAGNOSTIC AND POSSIBLE REHABILITATION OF PATIENTS WITH PREMATURE OVARIAN FAILURE (clinical lecture)

Genetic aspects of POI and «poor response»: a modern view of the problem

Coenzyme Q10 and embryonic development: a potential role in reproductive medicine

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