Pathogenesis of Ulcers of the Alkali-Burned Cornea

RETRACTED: Ophthalmic Combination of SurR9-C84A and Trichostatin-A Targeting Molecular Pathogenesis of Alkali Burn

“…MMP-9 plays a crucial role in dry eye, ocular surface diseases and can cause tissue damage (Kaufman, 2013 ), as it has the potential of degrading the extracellular matrix components. We also observed elevated expression of MMP-9 in aqueous humor from alkali burnt cornea, similar to the previous results (Brown et al, 1969 , 1970 ; Gnadinger et al, 1969 ), and a highly significant reduction ( p < 0.01, 11.5 fold) in MMP-9 was observed with the combinatorial treatment. Previously reports from alkali-burned mouse corneas revealed elevated levels of IL-1 (IL-1 beta), IL-6, IL-10, and TNF-alpha during the early stages of alkali burn (Sotozono et al, 1997 ).…”

RETRACTED: Ophthalmic Combination of SurR9-C84A and Trichostatin-A Targeting Molecular Pathogenesis of Alkali Burn

“…MMP-9 plays a crucial role in dry eye, ocular surface diseases and can cause tissue damage (Kaufman, 2013 ), as it has the potential of degrading the extracellular matrix components. We also observed elevated expression of MMP-9 in aqueous humor from alkali burnt cornea, similar to the previous results (Brown et al, 1969 , 1970 ; Gnadinger et al, 1969 ), and a highly significant reduction ( p < 0.01, 11.5 fold) in MMP-9 was observed with the combinatorial treatment. Previously reports from alkali-burned mouse corneas revealed elevated levels of IL-1 (IL-1 beta), IL-6, IL-10, and TNF-alpha during the early stages of alkali burn (Sotozono et al, 1997 ).…”

Effects of a 5% monosulfated glycosaminoglycan and duasorb topic solution on alkali-burned rabbit corneas

“…Animals who suffered perforation of the cornea presented few newly formed vessels before the perforation. This finding confirms the importance of neovascularization in the process of corneal repair (Brown et al, 1969;Pfister and Burstein, 1976;Wagoner, 1997). Newly formed vessels were mainly located in the anterior third of the stroma, as previously reported in the literature (Hughes, 1946).…”

“…The evolution of the ulcers did not differ from that reported in the literature (Brown et al, 1969;Burns et al, 1990). The variable behavior in terms of the number and location of the ulcers agreed with data reported by other authors (Pfister and Burstein, 1976) who described the persistence of epithelial defects tending to progress to ulcers and perforations even after corneal reepithelialization.…”

Experimental Pseudomonas aeruginosa Infection of the Mouse Cornea

“…The corneal pathology persisted beyond the period of infection. Whereas no similar experiments have been reported previously, the results are consistent with the previous observations that corneal pathology is caused by the extracellular enzymes (3,5) and that such enzymes trigger a long-lasting progression of inflammatory-repair events (1). A greater understanding of the nature of the defense and repair is important to the design of future experiments on therapy and prophylaxis.…”

RETRACTED: Ophthalmic Combination of SurR9-C84A and Trichostatin-A Targeting Molecular Pathogenesis of Alkali Burn

“…MMP-9 plays a crucial role in dry eye, ocular surface diseases and can cause tissue damage (Kaufman, 2013 ), as it has the potential of degrading the extracellular matrix components. We also observed elevated expression of MMP-9 in aqueous humor from alkali burnt cornea, similar to the previous results (Brown et al, 1969 , 1970 ; Gnadinger et al, 1969 ), and a highly significant reduction ( p < 0.01, 11.5 fold) in MMP-9 was observed with the combinatorial treatment. Previously reports from alkali-burned mouse corneas revealed elevated levels of IL-1 (IL-1 beta), IL-6, IL-10, and TNF-alpha during the early stages of alkali burn (Sotozono et al, 1997 ).…”

Effects of a 5% monosulfated glycosaminoglycan and duasorb topic solution on alkali-burned rabbit corneas

“…Animals who suffered perforation of the cornea presented few newly formed vessels before the perforation. This finding confirms the importance of neovascularization in the process of corneal repair (Brown et al, 1969;Pfister and Burstein, 1976;Wagoner, 1997). Newly formed vessels were mainly located in the anterior third of the stroma, as previously reported in the literature (Hughes, 1946).…”

“…The evolution of the ulcers did not differ from that reported in the literature (Brown et al, 1969;Burns et al, 1990). The variable behavior in terms of the number and location of the ulcers agreed with data reported by other authors (Pfister and Burstein, 1976) who described the persistence of epithelial defects tending to progress to ulcers and perforations even after corneal reepithelialization.…”

Experimental Pseudomonas aeruginosa Infection of the Mouse Cornea

“…The corneal pathology persisted beyond the period of infection. Whereas no similar experiments have been reported previously, the results are consistent with the previous observations that corneal pathology is caused by the extracellular enzymes (3,5) and that such enzymes trigger a long-lasting progression of inflammatory-repair events (1). A greater understanding of the nature of the defense and repair is important to the design of future experiments on therapy and prophylaxis.…”

RETRACTED: Ophthalmic Combination of SurR9-C84A and Trichostatin-A Targeting Molecular Pathogenesis of Alkali Burn

“…MMP-9 plays a crucial role in dry eye, ocular surface diseases and can cause tissue damage (Kaufman, 2013 ), as it has the potential of degrading the extracellular matrix components. We also observed elevated expression of MMP-9 in aqueous humor from alkali burnt cornea, similar to the previous results (Brown et al, 1969 , 1970 ; Gnadinger et al, 1969 ), and a highly significant reduction ( p < 0.01, 11.5 fold) in MMP-9 was observed with the combinatorial treatment. Previously reports from alkali-burned mouse corneas revealed elevated levels of IL-1 (IL-1 beta), IL-6, IL-10, and TNF-alpha during the early stages of alkali burn (Sotozono et al, 1997 ).…”

Effects of a 5% monosulfated glycosaminoglycan and duasorb topic solution on alkali-burned rabbit corneas

“…Animals who suffered perforation of the cornea presented few newly formed vessels before the perforation. This finding confirms the importance of neovascularization in the process of corneal repair (Brown et al, 1969;Pfister and Burstein, 1976;Wagoner, 1997). Newly formed vessels were mainly located in the anterior third of the stroma, as previously reported in the literature (Hughes, 1946).…”

“…The evolution of the ulcers did not differ from that reported in the literature (Brown et al, 1969;Burns et al, 1990). The variable behavior in terms of the number and location of the ulcers agreed with data reported by other authors (Pfister and Burstein, 1976) who described the persistence of epithelial defects tending to progress to ulcers and perforations even after corneal reepithelialization.…”

Experimental Pseudomonas aeruginosa Infection of the Mouse Cornea

“…The corneal pathology persisted beyond the period of infection. Whereas no similar experiments have been reported previously, the results are consistent with the previous observations that corneal pathology is caused by the extracellular enzymes (3,5) and that such enzymes trigger a long-lasting progression of inflammatory-repair events (1). A greater understanding of the nature of the defense and repair is important to the design of future experiments on therapy and prophylaxis.…”