Pathogenesis of Salmonella enteritidis phage type four after experimental infection of young chickens

Desmidt, Maria; Ducatelle, Richard; Haesebrouck, Freddy

doi:10.1016/s0378-1135(96)01350-8

Cited by 94 publications

(65 citation statements)

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“…A maior expressão celular na mucosa intestinal dos frangos desafiados é devido à alta patogenicidade e capacidade imunogênica que possuem SE e ST (Hassan et al 1991, Desmidt et al 1997. Durante a infecção intestinal estes dois sorovares penetram nos enterócitos resultando em uma resposta inflamatória considerável, ao contrário da Salmonella Pullorum e Gallinarum que geram uma resposta inflamatória muito menor no intestino e maior em outros tecidos que colonizam (Barrow et al 2012).…”

Section: Discussionunclassified

Avaliação da resposta imunológica da mucosa intestinal de frangos de corte desafiados com diferentes sorovares de Salmonella

et al. 2015

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RESUMO.-Objetivou-se com o presente estudo comparar o efeito de diferentes sorovares de Salmonella na resposta imune local da mucosa do intestino de frangos de corte. Aos sete dias de idade, as aves foram desafiadas com os sorovares S. Enteritidis, S. Typhimurium, S. Senftenberg, S. Mbandaka e S. Minnesota. Foi observado que todos os sorovares testados foram capazes de colonizar o intestino das aves sendo possível o isolamento de Salmonella em suabes de cloaca, 48 h após inoculação. De maneira geral, as aves do grupo controle negativo, que não foram desafiados apresentaram quantidade significativamente menor de células imunológicas na mucosa intestinal do que as aves desafiadas. Porém, verificou--se que os sorovares de Salmonella, utilizados neste estudo, apresentaram diferentes efeitos sobre a dinâmica celular da mucosa do íleo e ceco e afetaram de modo diferente o ganho de peso e ganho médio diário das aves demonstrando distintos graus de patogenicidade. Os sorovares Enteritidis e Typhimurium apresentaram um efeito mais intenso tanto no desempenho quanto na mobilização de células imunoló-gicas na mucosa intestinal de frangos de corte. The study was designed to compare the effect of different Salmonella serovars in immune response across the count of CD8+ cells, CD4+ cells, goblet cells and macrophages in the gut mucosa of broilers. During the experimental inoculation at 7 day-old were used Salmonella enterica subspecies enterica sorovars Enteritidis, Typhimurium, Senftenberg, Mbandaka and Minnesota. It was observed that all serovars tested were capable of contaminating the poultry being possible counts of Salmonella in cloacal swabs, 48 h after inoculation and into the crop and cecum, at 14 and 20 day-old. Serovars tested had different effects on broiler performance assessed at 20 days. In the mucosa of the ileum and cecum of broilers, it was observed that some of the serotypes increased CD8 + cells, CD4 + cells, goblet cells and macrophages compared to the negative control group both at 14 and at 20 day-old. S. Enteritidis and S. Typhimurium are the serovars that showed the more intense effect in live performance and in the immune system of birds showing pathogenic characteristic; generally the broilers of the negative control showed significantly less immune cells on the intestinal mucosa than broilers inoculated experimentally. However, it was found that the Salmonella serovars used in this study had different effects on the cellular dynamics of the mucosa of the ileum and cecum and differently affect weight gain and average daily gain of poultry showing different levels of pathogenicity. Avaliação da resposta imunológica da mucosa intestinal

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Section: Discussionunclassified

Avaliação da resposta imunológica da mucosa intestinal de frangos de corte desafiados com diferentes sorovares de Salmonella

et al. 2015

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“…Bone marrow localization of salmonella in other animals frequently affected by this micro-organism, such as cattle, sheep and poultry have not been described, although only few reports are available [212]. Rather, localization of salmonella from poultry occurs mostly in the lower intestinal tract, associated with granulomatous nodules, and in the bursa of Fabricius [213,214].…”

Section: Extraintestinal Infection : Interaction With the Reticulo-enmentioning

confidence: 99%

Host adapted serotypes of Salmonella enterica

et al. 2000

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Salmonella constitutes a genus of zoonotic bacteria of worldwide economic and health importance. The current view of salmonella taxonomy assigns the members of this genus to two species: S. enterica and S. bongori. S. enterica itself is divided into six subspecies, enterica, salamae, arizonae, diarizonae, indica, and houtenae, also known as subspecies I, II, IIIa, IIIb, IV, and VI, respectively [1]. Members of Salmonella enterica subspecies enterica are mainly associated with warm-blooded vertebrates and are usually transmitted by ingestion of food or water contaminated by infected faeces. The pathogenicity of most of the distinct serotypes remains undefined, and even within the most common serotypes, many questions remain to be answered regarding the interactions between the organism and the infected host.Salmonellosis manifests itself in three major forms: enteritis, septicaemia, and abortion, each of which may be present singly or in combination, depending on both the serotype and the host involved. Although currently over 2300 serovars of Salmonella are recognized, only about 50 serotypes are isolated in any significant numbers as human or animal pathogens [2, 3] and they all belong to subspecies enterica. Of these, most cause acute gastroenteritis characterized by a short incubation period and a severe systemic disease in man or animals, characterized by septicaemia, fever and/or abortion, and such serotypes are often associated with one or few host species [4–6].It is the intention of this review to present a summary of current knowledge of these host-adapted serotypes of S. enterica. The taxonomic relationships between the serotypes will be discussed together with a comparison of the pathology and pathogenesis of the disease that they cause in their natural host(s). Since much of our knowledge on salmonellosis is based on the results of work on Typhimurium, this serotype will often be used as the baseline in discussion. It is hoped that an appreciation of the differences that exist in the way these serotypes interact with the host will lead to a greater understanding of the complex host–parasite relationship that characterizes salmonella infections.

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“…Newly hatched chicks are highly susceptible to Salmonella infections during the first days of life and inoculation with very low doses can result in persistent infections [2,8,9]. This high susceptibility has been associated with the absence of normal gut microbiota [3,4] and the immature immune system of young chickens [5][6][7].…”

Section: Discussionmentioning

confidence: 99%

“…A nalidixic acid-resistant Salmonella Enteritidis hilAssrAfliG deletion mutant, which has been described earlier [15], was also used in this study. The original Salmonella Enteritidis 76Sa88 strain, from which the Salmonella Enteritidis hilAssrAfliG deletion mutant is derived, was originally isolated from a poultry farm [2,19]. Salmonella Enteritidis 147 (streptomycin resistant), a strain originally isolated from chicken egg white and which is known to colonise the gut and internal organs of chickens to a high level [12,20,21], was used as a challenge strain.…”

Section: Bacterial Strains and Deletion Mutantsmentioning

confidence: 99%

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A colonisation-inhibition culture consisting of Salmonella Enteritidis and Typhimurium ΔhilAssrAfliG strains protects against infection by strains of both serotypes in broilers

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Pathogenesis of Salmonella enteritidis phage type four after experimental infection of young chickens

Cited by 94 publications

References 15 publications

Avaliação da resposta imunológica da mucosa intestinal de frangos de corte desafiados com diferentes sorovares de Salmonella

Avaliação da resposta imunológica da mucosa intestinal de frangos de corte desafiados com diferentes sorovares de Salmonella

Host adapted serotypes of Salmonella enterica

A colonisation-inhibition culture consisting of Salmonella Enteritidis and Typhimurium ΔhilAssrAfliG strains protects against infection by strains of both serotypes in broilers

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