Pathogenesis of presbycusis in animal models: A review

Fetoni, Anna Rita; Picciotti, Pasqualina Maria; Paludetti, Gaetano; Troiani, Diana

doi:10.1016/j.exger.2010.12.003

Cited by 162 publications

(182 citation statements)

References 132 publications

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“…Aged-related alterations in the microcirculation of the stria vascularis have been described in several experimental models (Shi 2011 ). The metabolic rate is high in the stria vascularis (Gates and Mills 2005 ;Fetoni et al 2011 ;Böttger and Schacht 2013 ). Aged gerbils show atrophy and loss of strial capillaries that gradually expands from the apical to the middle region of the cochlea (Gratton and Schulte 1995 ).…”

Section: Histopathology Of Age-related Hearing Loss As a Mechanistic mentioning

confidence: 97%

“…Aged gerbils show a prominent degeneration and atrophy of the stria vascularis (Fetoni et al 2011 ). They exhibit a progressive pathology of marginal and intermediate cells and of the Na + K + ATPase-positive fi brocytes in the spiral ligament Schulte 2002 , 2005 ;Gates and Mills 2005 ).…”

Section: Histopathology Of Age-related Hearing Loss As a Mechanistic mentioning

confidence: 98%

“…Strial pathology seems to be a common feature of ARHL in both humans and animal models. Actually it is the earliest identifi ed pathological sign in the age-damaged cochlea, fi rst seen in the third decade of life in humans, and it has the highest heritability index (Gates and Mills 2005 ;Ohlemiller 2009 ;Fetoni et al 2011 ;Yamasoba et al 2013 ). However, hearing loss characterized clinically as strial presbycusis sometimes includes loss of hairs cells in the basal turn of the cochlea as the most visible pathology.…”

Section: Histopathology Of Age-related Hearing Loss As a Mechanistic mentioning

confidence: 99%

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Cellular Mechanisms of Age-Related Hearing Loss

Melgar–Rojas

Alvarado

Fuentes–Santamaría

et al. 2015

Oxidative Stress in Applied Basic Research and Clinical Practice

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Section: Histopathology Of Age-related Hearing Loss As a Mechanistic mentioning

confidence: 97%

Section: Histopathology Of Age-related Hearing Loss As a Mechanistic mentioning

confidence: 98%

Section: Histopathology Of Age-related Hearing Loss As a Mechanistic mentioning

confidence: 99%

See 1 more Smart Citation

Cellular Mechanisms of Age-Related Hearing Loss

Melgar–Rojas

Alvarado

Fuentes–Santamaría

et al. 2015

Oxidative Stress in Applied Basic Research and Clinical Practice

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“…The high prevalence of hearing loss among the elderly may be explained by numerous factors such as mutations of mitochondrial DNA, genetic disorders, hypertension, diabetes, metabolic and other systemic diseases. Excess noise and poor diet over a long time, as well as the use of certain medications [8][9][10] , may also be involved, and are further complicated by the aging process.…”

Section: Introductionmentioning

confidence: 99%

Percepção da perda auditiva: utilização da escala subjetiva de faces para triagem auditiva em idosos

Costa-Guarisco

Dalpubel

Labanca

et al. 2017

Ciênc. saúde coletiva

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“…The BLB within the perilymph-filled areas that are part of the blood-perilymph barrier include the cochlear spiral ligament, spiral limbus, modiolus, osseous spiral lamina, vestibular stromal vasculature and the sub-epithelial dark cell area 13 . The vestibular BLB unit in the rodent is similar to the rodent strial BLB unit at the light microscopic level: composed of vascular endothelial cells, pericytes and perivascular-resident macrophage-like melanocytes Recent studies have implicated loss of the integrity of the BLB in several inner ear pathologies including acoustic trauma, autoimmune inner ear disease, and presbycusis 3,7,8,[14][15][16] . Meniere's disease is a disabling syndrome of fluctuating hearing loss, episodic vertigo, and ear fullness, the etiology and pathophysiology of which remain poorly understood.…”

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confidence: 99%

Recent Research Trend for Ménièreʼs Disease

Nam¹

2017

Res Vestib Sci

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The ultrastructural organization of the blood labyrinthine barrier (BLB) was investigated in the human vestibular endorgan, the utricular macula, using postmortem specimens from individuals with documented normal auditory and vestibular function and surgical specimens from patients with intractable Meniere's disease. Transmission electron microscopic analysis of capillaries located in the normal human utricular stroma showed vascular endothelial cells with few pinocytotic vesicles, covered by a smooth and uniform basement membrane surrounded by pericyte processes. Meniere's disease specimens revealed differential ultrastructural pathological changes in the cellular elements of the microvasculature. With moderate degeneration of the BLB, there were numerous vesicles within the vascular endothelial cells (VECs), with increased numbers at the abluminal face, pericyte process detachment and disruption of the perivascular basement membrane surrounding the VECs. With severe degeneration of the BLB, there was severe vacuolization or frank apparent necrosis of VECs and loss of subcellular organelles. A higher severity of BLB degenerative changes was associated with a higher degree of basement membrane thickening and edematous changes within the vestibular stroma. This study presents the first ultrastructural analysis of the capillaries constituting the BLB in the human vestibular macula utricle from normal and Meniere's disease.In the inner ear, the term blood labyrinthine barrier (BLB) refers to the barrier between the vasculature and the inner ear fluids, either endolymph or perilymph 1, 2 . The BLB is critical for the maintenance of the inner ear fluid ionic homeostasis and for the prevention of the entry of deleterious substances into the inner ear 3 . By studying the penetration of dyes and drugs from the systemic circulation into the fluids of the inner ear, it can be shown that the BLB is selective and that the composition of the inner ear fluids is regulated and markedly different from that of blood or of other fluids such as cerebrospinal fluid 2 . Understanding the dynamics of the BLB is important to develop therapeutic drug delivery systems to the inner ear to block or enhance the BLB inflammatory response. The BLB in the cochlea is well studied in animal models 2,4,5 . Initial transmission electron microscopy (TEM) studies demonstrated that the BLB in the guinea pig stria vascularis and spiral ligament is composed of vascular endothelial cells (VECs) surrounded by a basement membrane 6 . More recent studies have noted that, in addition, the intrastrial BLB is composed of pericytes and perivascular-resident macrophage-like melanocytes [7][8][9][10][11] . The VECs line the interior surface of the blood vessels, connected by tight junctions, forming an interface between circulating blood and the rest of the vessel wall. Pericytes are the only cell type to intimately connect with VECs as they lie embedded within the endothelial basement membrane. The perivascular-resident macrophage-like melanocytes have foot pr...

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Pathogenesis of presbycusis in animal models: A review

Cited by 162 publications

References 132 publications

Cellular Mechanisms of Age-Related Hearing Loss

Cellular Mechanisms of Age-Related Hearing Loss

Percepção da perda auditiva: utilização da escala subjetiva de faces para triagem auditiva em idosos

Recent Research Trend for Ménièreʼs Disease

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