Pathogenesis of Higher Blood Pressure and Worse Renal Function in Salt-Sensitive Hypertension

Chu, Yu-Yi; Zhou, Yan; Lu, Shiqi; Lu, Feng Hwa; Hu, Yuanhui

doi:10.1159/000515088

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…The main physiological function of the kidney is to regulate water, electrolytes, blood volume, and excrete metabolites in the body. Renal dysfunction can lead to water and sodium retention and increased blood volume, resulting in increased blood pressure ( 24 ). Fourth, the vascular mechanism (i.e., endothelial dysfunction and the nitric oxide pathway).…”

Section: Discussionmentioning

confidence: 99%

Development and validation of a decision tree classification model for the essential hypertension based on serum protein biomarkers

Han¹,

Luo²

2022

Ann Transl Med

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Background: Essential hypertension (EH) is a key risk factor for cardiovascular disease. However, the etiology of EH is complex and unknown. So far, there is no good protein biomarker for screening EH. The purpose of this study was to discover potential biomarkers for EH by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and establish a decisiontree classification model. Methods: A total of 108 patients with clinically confirmed EH and 105 HC were enrolled in the present study from September 2020 to April 2021 and were randomly divided into the training group and the blindtest group. The serum protein expression profiles were performed using MALDI-TOF MS combined with magnetic beads with weak cation exchange (MB-WCX). The training group, which comprised 54 EH patients and 53 HC, was used to screen the statistically differential protein peaks by SPSS 19.0 and construct a decision-tree classification model by C5.0 algorithms of SPSS Modeler 18.0. All protein peak intensities of samples in the blind-test group, which comprised 54 EH patients and 52 HC, were used to verify the diagnostic capabilities of the model by classification model.Results: EH patients had higher age, systolic and diastolic blood pressures than HC group. The intensities of 60 protein peaks differed significantly between the EH patients and HC. An optimal decision-tree classification model of EH was successfully established with mass-to-charge ratios of 1,326.7, 1,785.3, 4,228.0, and 8,963.8 as differential protein peaks by the software analysis. The decision-tree classification model was able to distinguish between EH patients and HC and had a sensitivity of 94.44%, a specificity of 94.33%, an accuracy of 94.39%, and an area under the receiver operating characteristic (ROC) curve of 0.96. The blindtest results indicated a sensitivity of 87.04%, a specificity of 88.46%, an accuracy of 87.74%, and an area under the ROC curve of 0.928.Conclusions: MALDI-TOF MS combined with MB-WCX can be used to screen for serum differential protein expression profiles in EH patients. The decision-tree classification model based on mass-to-charge ratios of 1,326.7, 1,785.3, 4,228.0, and 8,963.8 could provide a new and reliable method for screening and identifying EH with high sensitivity and specificity.

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Section: Discussionmentioning

confidence: 99%

Development and validation of a decision tree classification model for the essential hypertension based on serum protein biomarkers

Han¹,

Luo²

2022

Ann Transl Med

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“…A study by Chu et al, in 329 subjects looked at growth factors that are produced in relation to the activation of the phosphoinositide 3-kinase/ Ak strain transforming (PI3K-Akt) pathway, which is activated through serine and/or threonine phosphorylation of a range of downstream substrates ( 169 ). They found that individuals with SSBP had elevated levels of several growth factors compared to salt resistant group ( 169 ). The signal transduction PI3K-Akt Pathway regulates metabolism, proliferation, cell survival, growth and angiogenesis ( 170 ).…”

Section: Dietary Salt In Hypertensive Heart Disease and Its Complicat...mentioning

confidence: 99%

Hypertensive heart disease: risk factors, complications and mechanisms

Masenga

Kirabo

2023

Front. Cardiovasc. Med.

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Hypertensive heart disease constitutes functional and structural dysfunction and pathogenesis occurring primarily in the left ventricle, the left atrium and the coronary arteries due to chronic uncontrolled hypertension. Hypertensive heart disease is underreported and the mechanisms underlying its correlates and complications are not well elaborated. In this review, we summarize the current understanding of hypertensive heart disease, we discuss in detail the mechanisms associated with development and complications of hypertensive heart disease especially left ventricular hypertrophy, atrial fibrillation, heart failure and coronary artery disease. We also briefly highlight the role of dietary salt, immunity and genetic predisposition in hypertensive heart disease pathogenesis.

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“…Functional impairment of the kidneys is also a frequent disorder in the presence of high blood pressure, also known as hypertension. It has been thought that renal damage linked to hypertension is caused by oxidative stress [ 146 , 147 , 148 ]. In this regard, ALA has also been tested for its antioxidant role in hypertension-induced kidney injury.…”

Section: Miscellaneousmentioning

confidence: 99%

Renal-Protective Roles of Lipoic Acid in Kidney Disease

Kamt

Liu

2023

Nutrients

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The kidney is a crucial organ that eliminates metabolic waste and reabsorbs nutritious elements. It also participates in the regulation of blood pressure, maintenance of electrolyte balance and blood pH homeostasis, as well as erythropoiesis and vitamin D maturation. Due to such a heavy workload, the kidney is an energy-demanding organ and is constantly exposed to endogenous and exogenous insults, leading to the development of either acute kidney injury (AKI) or chronic kidney disease (CKD). Nevertheless, there are no therapeutic managements to treat AKI or CKD effectively. Therefore, novel therapeutic approaches for fighting kidney injury are urgently needed. This review article discusses the role of α-lipoic acid (ALA) in preventing and treating kidney diseases. We focus on various animal models of kidney injury by which the underlying renoprotective mechanisms of ALA have been unraveled. The animal models covered include diabetic nephropathy, sepsis-induced kidney injury, renal ischemic injury, unilateral ureteral obstruction, and kidney injuries induced by folic acid and metals such as cisplatin, cadmium, and iron. We highlight the common mechanisms of ALA’s renal protective actions that include decreasing oxidative damage, increasing antioxidant capacities, counteracting inflammation, mitigating renal fibrosis, and attenuating nephron cell death. It is by these mechanisms that ALA achieves its biological function of alleviating kidney injury and improving kidney function. Nevertheless, we also point out that more comprehensive, preclinical, and clinical studies will be needed to make ALA a better therapeutic agent for targeting kidney disorders.

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Pathogenesis of Higher Blood Pressure and Worse Renal Function in Salt-Sensitive Hypertension

Cited by 5 publications

References 18 publications

Development and validation of a decision tree classification model for the essential hypertension based on serum protein biomarkers

Development and validation of a decision tree classification model for the essential hypertension based on serum protein biomarkers

Hypertensive heart disease: risk factors, complications and mechanisms

Renal-Protective Roles of Lipoic Acid in Kidney Disease

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