Pathogenesis of H13 Nephropathogenic Infectious Bronchitis Virus

Abstract

A nephropathogenic Massachusetts strain of infectious bronchitis virus (IBV) designated H13-IBV was isolated from the kidneys of commercial broilers. H13-IBV caused respiratory distress, depression, and diarrhea in specific-pathogen-free chickens. Gross renal lesions included pale coloration, swelling, and urate deposition. Histologic renal changes were interstitial mononuclear cell infiltration and degeneration and necrosis of tubular epithelial cells. Lesions in respiratory tissues included thickening and edema of the air sacs, congestion of the tracheal mucosa, and frothy serous exudate. Histologic tracheal lesions were deciliation, mucous gland distortion, inflammatory cell infiltration, and squamous metaplasia. Clinically, H13-IBV was highly pathogenic in birds infected at 1 day of age and mildly pathogenic in birds infected at 4 weeks of age. Kidney lesions were of marked severity only in birds infected at 1 day of age. Tracheal lesions were similar in severity in both age groups.

Comparison of the pathogenicity of QX-like, M41 and 793/B infectious bronchitis strains from different pathological conditions

“…However, unlike previous studies where either severe kidney damage (Butcher et al, 1990;Chen et al, 1996) or alterations to the reproductive tract (Crinion & Hofstad, 1971) was reported following M41 infection, in our study no remarkable lesions or presence of viral RNA was detected in the other organs. This discrepancy might be caused by different passage levels, experimental conditions and design, breed or age of the birds, or by the use of different strains of M41.…”

Prevalence, Serodiagnosis and Histopathological Changes in Field Cases of Infectious Bronchitis in Chickens

“…If air sac involvement occurs, there is edema, epithelial cell desquamation, and some fibrinous exudates within 24 hrs (Riddell, 1987). Janse et al, (1994) also reported the comparable findings like deciliation, sqamous metaplasia, cellular infiltration, edema of mucous and exudates as noticed by other workers (Butcher et al, 1990;Mahdavi et al, 2007). The virus replicates in ciliated epithelial cells causing deciliation, odema, desquamation, hyperplasia and mononuclear cell infiltration.…”

“…were recorded in the flocks. Butcher et al, (1990), Kinde (1991) and Mahgoub et al, (2010) also with recorded similar clinical findings. The mortality ranged from 5.4 to 35.2% with average mortality of 12.2% were recorded (Table 1).…”

Leukocyte subpopulations in kidney and trachea of chickens infected with infectious bronchitis virus

“…The histological changes of the trachea epithelium were deciliation, squamous metaplasia, cell infiltration, oedema of the mucosa and exúdate. These results are similar to those described by Butcher et al (1990), Purcell & McFerran (1972) and Hofstad (1945).…”