Pathogenesis of glomerular haematuria

Yuste, Claudia; Gutiérrez, Eduardo; Sevillano, Ángel; Rubio‐Navarro, Alfonso; Amaro-Villalobos, Juan Manuel; Ortíz, Alberto; Egido, Jesús; Praga, Manuel; Moreno, Juan Antonio

doi:10.5527/wjn.v4.i2.185

Cited by 39 publications

(32 citation statements)

References 86 publications

(90 reference statements)

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“…We found that it was greater than in MCD, and similar in its extent to the area measured in acute transplant glomerulitis [16]. Endothelial cell enlargement may indicate cell damage and contribute to the development of haematuria, with negative prognostic implications [4,12]. The number of macrophages in glomeruli was positively correlated with diffuse deposition of IgA and fibrinogen, a result, to the best of our knowledge, shown for the first time.…”

Section: Discussionsupporting

confidence: 62%

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Prognostic value of morphologic and morphometric analyses in IgA nephropathy biopsies

et al. 2016

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Background: IgA nephropathy (IgAN) exhibits a variable course ranging from a benign condition to progressive renal failure with a high proportion of patients undergoing end-stage renal disease in the long term. It is unclear how to predict the risk of this progression. Mesangial C4d deposition has been found to be associated with a poor prognosis. Our aim was to search histological lesions with possible prognostic value in IgAN biopsies performed at the time of the diagnosis. Methods: Clinical and laboratory records of 44 patients undergoing renal biopsy were reviewed. IgAN was diagnosed in 32 patients and minimal change disease (MCD) in 12. C4d deposition, glomerular endothelial cell area, glomerular and interstitial macrophages were evaluated in all biopsies. Clinical and laboratory data were available in all IgAN patients at the time of diagnosis and in 21 patients at the end of follow-up (mean follow-up 48.09 ± 19.69 months). Results: All IgAN and MCD biopsies were C4d negative. The number of glomerular macrophages and the area of glomerular endothelial cells in IgAN were greater than in MCD (P < 0.001 and P < 0.0001, respectively), indicating glomerular inflammation associated with endothelial cell enlargement. Glomerular macrophages positively correlated with diffuse IgA and fibrinogen immunoreactivity (P < 0.02 and P < 0.002, respectively). Interstitial macrophages positively correlated with segmental glomerulosclerosis (P < 0.01) and tubular atrophy (P < 0.001), according to the Oxford classification. They correlated with hypertension (P < 0.03) and renal functional impairment both at the time of biopsy and at the end of follow-up. The receiver operating characteristic analysis curve and a cut-off value of ≥19.5 macrophages per high power field showed 75.0% sensitivity and 88.9% specificity in predicting worse clinical outcome. A Poisson generalized regression fit model showed that hypertension and tubular atrophy were the most significant factors in predicting a high number of interstitial macrophages. Conclusions: The number of interstitial macrophages correlated with hypertension, histological damage, functional impairment at the time of biopsy and worse outcome. A high number of interstitial macrophages in C4d negative biopsies may allow the identification of patients at increased risk of progression to renal failure.

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Section: Discussionsupporting

confidence: 62%

“…In IgAN the mechanism of haematuria is unknown, endothelial cell damage and alterations of the glomerular basal membrane may contribute to its development [4,12]. Whether endothelial cell enlargement is present in IgAN glomeruli has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of morphologic and morphometric analyses in IgA nephropathy biopsies

et al. 2016

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“…ROS destroy lipid membranes, proteins and nucleic acids [50] and induce apoptosis of epithelial tubular cells [51]. Furthermore, iron causes inflammation and damage to the kidney which is manifested as fibrosis [52].…”

Section: Heme Cytotoxicitymentioning

confidence: 99%

Renal involvement in paroxysmal nocturnal hemoglobinuria: an update on clinical features, pathophysiology and treatment

et al. 2018

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“…According to Liu et al (2014) the mesangial cell regulated fibronectin production by caveolin-1 phosphorylation. Kidney disease such as fibronectin glomerulopathy and fibrillary glomerulonephritis followed by alteration in glomerular basement membrane structure and other extracellular components leading to weaker and easily extracellular ruptured structures (Yuste et al, 2015). Therefore, fibronectine deregulation in the interstitial space causes imbalance between soluble and insoluble fibronectin leading to fibronectin glomerulopathy, although the prevalence rate is higher in adolescence (Deltas et al, 2012).…”

Section: Discussionmentioning

confidence: 93%

Alteration of fibronectine expression in the kidney extracellular matrix following nicotine administration in gestation and lactation period

Pahang¹,

Nikravesh²,

Jalali³

2016

Res. Opin. Anim. Vet. Sci.

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The aim of this study was to assess the effects of maternal nicotine exposure during pregnancy and lactation periods on fibronectine expression in the extracellular matrix of kidney of offspring. A total of 24 female pregnant Balb/c mice were randomly divided into four groups as follows: 3 mg/kg/day nicotine intraperitonealy (IP) from the 6 th day of uterine life until the end of pregnancy (E1), 3 mg/kg/day nicotine in a similar way from the first day of delivery to the end of lactation (E2), 3 ml/kg/day normal saline during pregnancy and lactation period as suggested for E1 and E2. The results showed that fibronectine reaction was significantly increased in the glomerule of E1. RT-PCR results demonstrated that the mRNA level of the fibronectin in the E2 group was up regulated significantly compared to the other group. From the results of the present study showed that maternal nicotine administration did not alter fibronectine expression in gestation and lactation life.

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Pathogenesis of glomerular haematuria

Cited by 39 publications

References 86 publications

Prognostic value of morphologic and morphometric analyses in IgA nephropathy biopsies

Prognostic value of morphologic and morphometric analyses in IgA nephropathy biopsies

Renal involvement in paroxysmal nocturnal hemoglobinuria: an update on clinical features, pathophysiology and treatment

Alteration of fibronectine expression in the kidney extracellular matrix following nicotine administration in gestation and lactation period

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