Pathogenesis of Disciform Detachment of the Neuroepithelium

Donald, J.; Gass, Margery

doi:10.1016/0002-9394(67)90030-x

Cited by 146 publications

(13 citation statements)

References 11 publications

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“…Particularly choroidal vascular abnormalities of eyes with CSC, including delayed filling, vascular congestion, choroidal vascular hyperpermeability, and punctate hyperfluorescent spots [17][18][19][20][21][22][23] have been previously described, suggesting that the primary pathogenesis of CSC and subretinal fluid is choroidal vascular disturbance in presence of RPE defects and abnormalities. 24,25 The flow rate (i.e., the volume of blood that passes a given point per unit time) is determined by pressure gradient and/or the size of the vessel. The peripheral resistance determines the direction of blood flow out of the choriocapillaris lobule.…”

Section: Discussionmentioning

confidence: 99%

Choroidal Vascular Flow Area in Central Serous Chorioretinopathy Using Swept-Source Optical Coherence Tomography Angiography

Nicolò¹,

Rosa

Musetti

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionmentioning

confidence: 99%

Choroidal Vascular Flow Area in Central Serous Chorioretinopathy Using Swept-Source Optical Coherence Tomography Angiography

Nicolò¹,

Rosa

Musetti

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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“…Considering the theories of pathophysiology of CSCR largely incriminating choroidal disorder with increased thickness, choriocapillary hyper-permeability, vascular congestion, and venous dilatation with exudation of serous fluid via weakened RPE to eventually cause SRF and visual loss [18][19][20][21][22][23], treatment should aim to interrupt those mechanism and cause resorption of SRF. Though there was no significant difference in choroidal parameters between the group, however, higher percentage of eyes had resolution of SRF in nMSL group compared to PDT group (59.09% vs 21.7%).…”

Section: Discussionmentioning

confidence: 99%

Comparison of photodynamic therapy and navigated microsecond laser for chronic central serous chorioretinopathy

Ntomoka¹,

Rajesh²,

Muriithi

et al. 2018

Eye

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“…Acute central serous chorioretinopathy (CSCR) is a disease that primarily affects the choroidal blood circulation and is characterized by an elevation of the central neurosensory retina due to subretinal or subretinal pigment epithelium fluid (SRF; sub-RPE) accumulation leading to various visual symptoms and a reduced vision-related quality of life [1,2]. Although acute CSCR shows a favorable natural regression in the majority of affected eyes, recurrence occurs in approximately 50 percent and can lead to an irreversible RPE damage [3].…”

Section: Introductionmentioning

confidence: 99%

Long-Term Effect of Half-Fluence Photodynamic Therapy on Fundus Autofluorescence in Acute Central Serous Chorioretinopathy

Stattin¹,

Hagen²,

Ahmed³

et al. 2020

Journal of Ophthalmology

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Purpose. To evaluate normalized short-wavelength fundus autofluorescence (SW-FAF) imaging changes over time as a predictive parameter for the retinal pigment epithelium (RPE) function in eyes compromised by acute central serous chorioretinopathy (CSCR) after indocyanine green angiography-guided verteporfin (Visudyne®, Novartis Pharma, Basel, Switzerland) photodynamic therapy (PDT) with a half-fluence rate (25 J/cm2). Methods. Quantitative data of SW-FAF grey values (SW-FAF GV) from a 350 μm (SW-350) and 1200 μm (SW-1200) diameter circle centered on the fovea and normalized with the level of SW-FAF GV in a 30° image of 20 eyes in 11 patients initially treated for unilateral acute symptomatic CSCR were collected and retrospectively analyzed after 7 years. A 2-sided t-test was calculated to explore the differences of SW-350 and SW-1200 between one month and the long-term follow-up. Results. Mean differences (95% CI) in SW-FAF GV between 1 month and 7 years after half-fluence PDT were 0.07 ± 0.11 for SW-350 ([95% CI: −0.002; 0.14], p=0.06) and 0.11 ± 0.15 for SW-1200 ([95% CI: 0.01; 0.21], p=0.03). Mean differences in SW-FAF GV of the contralateral untreated eye were 0.06 ± 0.14 for SW-350 ([95% CI: −0.04; 0.17], p=0.22) and 0.05 ± 0.13 for SW-1200 ([95% CI: −0.04; 0.15], p=0.22). Conclusion. After 7 years, normalized SW-FAF GV were significantly lower in eyes with resolved acute CSCR treated with reduced-fluence PDT compared to the follow-up after 1 month without correlation to explicit pattern changes or structural damages. Half-fluence PDT remains a safe and considerable treatment option in acute CSCR.

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Pathogenesis of Disciform Detachment of the Neuroepithelium

Cited by 146 publications

References 11 publications

Choroidal Vascular Flow Area in Central Serous Chorioretinopathy Using Swept-Source Optical Coherence Tomography Angiography

Choroidal Vascular Flow Area in Central Serous Chorioretinopathy Using Swept-Source Optical Coherence Tomography Angiography

Comparison of photodynamic therapy and navigated microsecond laser for chronic central serous chorioretinopathy

Long-Term Effect of Half-Fluence Photodynamic Therapy on Fundus Autofluorescence in Acute Central Serous Chorioretinopathy

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