Choroidal Vascular Flow Area in Central Serous Chorioretinopathy Using Swept-Source Optical Coherence Tomography Angiography

Nicolò, Massimo; Rosa, Raffaella De; Musetti, Donatella; Musolino, Maria; Saccheggiani, Michela; Traverso, Carlo Enrico

doi:10.1167/iovs.17-21417

Cited by 71 publications

(72 citation statements)

References 37 publications

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“…The choroidal vascular flow area was larger in CSC eyes compared with control eyes. At the same time, Nicolò et al [32] demonstrated differences in flow areas between CC and deeper choroidal levels in eyes with CSC, possibly a result of compensatory flow mechanisms within the choroid/CC.…”

Section: Octa In Cscmentioning

confidence: 94%

“…The CC decorrelation signal index was defined as the average decorrelation value of all pixels in the en face CC angiogram [28]. Binarization of OCTA images was described by Nicolò et al [32] using the Otsu method, which is an automatic threshold selection from DOI: 10.1159/000485261 gray-level histograms. Binarization relies on conversion of a "noised" image in a white/black dichotomy, applying an automatic threshold to the original grayscale.…”

Section: Heidelberg Spectralismentioning

confidence: 99%

“…Bonini Filho et al [65] compared the sensitivity and specificity of FA and OCTA with focus on CNV detection in chronic CSC and found a comparable sensitivity and specificity for the use of OCTA and coregistered OCT B-scans compared to FA. Nicolò et al [32] examined quantitative changes of choroidal flow areas using SS-OCTA. Interestingly, in that study, dark patterns of the choroid were present regardless of the amount of fluid in CSC as well as in fellow eyes, but such alterations were not present in healthy eyes.…”

Section: Octa In Cscmentioning

confidence: 99%

See 2 more Smart Citations

Optical Coherence Tomography Angiography Offers New Insights into Choriocapillaris Perfusion

Lauermann¹,

Eter²,

Alten³

2018

Ophthalmologica

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The choriocapillaris (CC) represents a fundamentally important vascular layer that is subject to physiologic changes with increasing age and that is also associated with a wide range of chorioretinal diseases. So far, information on blood flow in this specific layer has remained limited. With the advent of optical coherence tomography angiography (OCTA), new perspectives and possibilities of CC imaging have begun to evolve. This article shall review the opportunities and challenges of applying OCTA technology to the CC layer and summarize the current clinical efforts in OCTA CC imaging exemplarily in dry age-related macular degeneration and central serous chorioretinopathy.

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Section: Octa In Cscmentioning

confidence: 94%

Section: Heidelberg Spectralismentioning

confidence: 99%

Section: Octa In Cscmentioning

confidence: 99%

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Optical Coherence Tomography Angiography Offers New Insights into Choriocapillaris Perfusion

Lauermann¹,

Eter²,

Alten³

2018

Ophthalmologica

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“…It has been suggested that the percentage of white (CC) or black pixels (SL and HL) is an indirect measure of the choroidal vascular flow area (Nicolò et al. ). Therefore the white or black pixel value of the respective layer was calculated and divided by the whole scan area to determine CCP, SLP and HLP.…”

Section: Methodsmentioning

confidence: 99%

Evaluating diurnal changes in choroidal sublayer perfusion using optical coherence tomography angiography

Siegfried

Rommel

Rothe

et al. 2019

Acta Ophthalmologica

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Purpose: To investigate diurnal changes of choroidal sublayer perfusion in normal eyes and to identify influencing factors using optical coherence tomography angiography (OCTA). Methods: A prospective study was conducted on healthy volunteers, each of whom underwent repeated measurements of subfoveal choroidal thickness (SFCT) via enhanced depth imaging (EDI) optical coherence tomography (OCT) as well as perfusion of choroidal vascular sublayers using OCTA at 7 a.m., 12 p.m., 4 p.m. and 8 p.m. Possible interactions between diurnal variations and other factors, such as mean arterial pressure (MAP), gender and age, were evaluated. Results: A total of 22 eyes from 22 participants were analysed. Mean age of participants was 56 years. A significant pattern of diurnal variation was observed for SFCT (p < 0.001) as well as perfusion of Sattler's layer (SLP; p = 0.009) and Haller's layer (HLP; p = 0.003). SFCT demonstrated a linear decrease, being thicker in the morning (348 lm) and thinner in the evening (310 lm). Both, SLP and HLP showed a quadratic relation to time of day, increasing from morning (64% and 76%) to afternoon (66% and 77%), before decreasing again in the evening (64% and 76%). HLP changes were significantly associated with fluctuations of MAP (B = 0.0007; CI 0.0001-0.0014; p = 0.047). No significant differences with regard to gender were detectable. However, older participants (≥60 years) had fewer diurnal changes (p = 0.042). Conclusion: Optical coherence tomography angiography-based analysis of choroidal sublayer perfusion demonstrated significant diurnal variations. Therefore, it is important to account for time of day, when comparing longitudinal OCTA data.

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“…It has been postulated that CSC may be an ocular condition caused by a systemic disease that involves choroidal circulation 1 , which could be potentially supported by previous results of some systemic risk factors 1 and abnormalities of CC and SFCT in self-resolved CSC eyes and the unaffected eyes 11,[19][20][21] . Similarly, our study demonstrated that FSV in unaffected eyes of CCSC were higher than those in healthy individuals, and remained statistically unchanged over time.…”

Section: Discussionmentioning

confidence: 78%

Assessment of choriocapillary blood flow changes in response to half-dose PDT in chronic central serous chorioretinopathy using OCTA

Liu

Chen²,

et al. 2020

Preprint

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Background: To quantify flow changes in choriocapillaris (CC) in patients with chronic central serous chorioretinopathy (CCSC) in the treatment of half-dose photodynamic therapy (PDT) using optical coherence tomography angiography (OCTA) . Methods : A total of 28 affected eyes and 24 unaffected eyes of 26 CCSC patients receiving half-dose PDT, and 40 eyes of 20 healthy gender- and age-matched subjects were retrospectively enrolled. Proportion of total areas of flow signal voids ( FSV , %) in CC level of OCTA were mainly assessments in both eyes of the CCSC patients at baseline and repeated in multiple sections at 1-week, 1-month, 3-month and 6-month intervals after PDT. In addition , CC patterns in response to PDT at early stage and their subsequent morphologic changes were qualitatively documented using OCTA. Results: For affected eyes, significant decrease in FSV was found at 6-m follow-up than 1-m follow-up (p=0.036). Comparing to normal control eyes, FSV in affected eyes was significantly higher at 1-m, 3-m and 6-m follow-up (p<0.05 for all), while FSV in unaffected eyes was significantly higher at baseline, 1-w, 1-m and 3-m follow-up (p<0.05 for all). Three CC patterns of early response to PDT can be identified, including signs of recovery with more even flow signals, transient appearance of worsen ischemia and secondary neovascularization within CC level. Conclusion: Abnormal CC flow attenuation remained in completely resolved eyes of CCSC patients treated with half-dose PDT. Key Words: Chronic; Central Serous Chorioretinopathy; Optical Coherence Tomography Angiography; Photodynamic Therapy

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Choroidal Vascular Flow Area in Central Serous Chorioretinopathy Using Swept-Source Optical Coherence Tomography Angiography

Abstract: Choroidal vascular flow area is larger in CSC eyes compared with control eyes. However, within the choroid of eyes with CSC, there might be some differences in flow area between CC and deeper choroidal levels. This difference might be secondary to a compensatory mechanism of the choroid.

Cited by 71 publications

References 37 publications

Optical Coherence Tomography Angiography Offers New Insights into Choriocapillaris Perfusion

Optical Coherence Tomography Angiography Offers New Insights into Choriocapillaris Perfusion

Evaluating diurnal changes in choroidal sublayer perfusion using optical coherence tomography angiography

Assessment of choriocapillary blood flow changes in response to half-dose PDT in chronic central serous chorioretinopathy using OCTA

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