“…This grading system classifies the lesions according to three criteria, i.e., (i) hyperplasia of epithelial cells, (ii) presence and extent of degeneration and necrosis, and (iii) presence and abundance of intranuclear inclusion bodies. As the number of presumed infected cells does not always correlate with the severity of the lesions, the combination of these criteria is necessary to obtain a reliable histopathological grading system (Boutier et al, 2015;Miwa et al, 2014).…”