Pathogenesis, Diagnosis and Treatment of Human Toxoplasmosis

A Proven Case of Congenital Toxoplasmosis

“…The naked eye and microscopical changes in congenital toxoplasmosis have been described in considerable detail by Frenkel and Friedlander (1951) and the findings in our case were substantially similar. In common with many previously reported cases the changes were largely confined to the central nervous system and the eye.…”

“…Owing to the small numbers of mice available it was not possible to follow the technique suggested by Frenkel (1949), who recommends the use of two groups of four to six mice each. One of these groups should be inoculated intracerebrally and the other intraperitoneally.…”

The coccidian parasites (Protozoa, Apicomplexa) of carnivores

“…The total cost of neonatal human toxoplasmosis in the United States was estimated by Frenkel (1973) (Hartley and Marshall, 1957;Kater, 1963, 1964). Levine (1973) and Beverley (1974) (Sabin and Feldman, 1948;Sabin et al, 1952), complement fixation test (Warren and Sabin, 1943;Sabin, 1949), hemagglutination test (Jacobs and Lunde, 1957), skin test (Frenkel, 1948(Frenkel, , 1949, fluorescine-labeled antibody test (Goldman, Carver, and Sulzer, 1957), and latex agglutination test (Lunde and Jacobs, 1967). The dye test and hemagglutination test are perhaps the most widely used.…”

Ocular Toxoplasmosis

“…58 The earlier concepts of the pathogenesis of toxo¬ plasmosis had been based on experience with the clinical syndromes of the neonatal forms and the fatal disseminated visceral forms in adults. 58 The earlier concepts of the pathogenesis of toxo¬ plasmosis had been based on experience with the clinical syndromes of the neonatal forms and the fatal disseminated visceral forms in adults.…”