“…Although the role of NF-kB in cancer biology is becoming progressively better established, historically much of our current knowledge of NF-kB resulted from efforts directed at understanding the regulation and function of the immune response. In keeping with the critical role played by NF-kB in different areas of immunology, numerous excellent reviews have been published covering the role of NF-kB in Toll-like receptor (TLR) and antigen receptor (AgR) signaling, lymphoid organogenesis and hematopoiesis (Mebius, 2003;Bonizzi and Karin, 2004;Hayden and Ghosh, 2004;Lin and Wang, 2004;Siebenlist et al, 2005;Akira et al, 2006). This review will, therefore, attempt to provide a more comprehensive, if less detailed, review of the diverse functions of NF-kB in immunology, with the goal of illuminating how it is that so much in immunology seems to revolve around this family of transcription factors.…”