Tuberculosis infection: Insight from immunogenomics

Arentz, Matthew; Hawn, Thomas R.

doi:10.1016/j.ddmec.2007.11.003

Cited by 25 publications

(17 citation statements)

References 47 publications

(62 reference statements)

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“…Thus, we speculate that differences in granuloma number as early as 3 weeks postinfection are due to innate immune responses modulating the establishment of initial infection. For example, airway factors that can be protective against active TB include alveolar macrophages, pattern recognition receptors, Toll-like receptors, surfactant proteins, and antimicrobial peptides (19)(20)(21). More creative methods of augmenting these first responders in the airway should be considered in the next generation of adjuvants and vaccines, as some authors have suggested (16,17).…”

Section: Discussionmentioning

confidence: 99%

Early Changes by ¹⁸ Fluorodeoxyglucose Positron Emission Tomography Coregistered with Computed Tomography Predict Outcome after Mycobacterium tuberculosis Infection in Cynomolgus Macaques

et al. 2014

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Cynomolgus macaques infected with low-dose Mycobacterium tuberculosis develop both active tuberculosis and latent infection similar to those of humans, providing an opportunity to study the clinically silent early events in infection.18 Fluorodeoxyglucose radiotracer with positron emission tomography coregistered with computed tomography (FDG PET/CT) provides a noninvasive method to measure disease progression. We sought to determine temporal patterns of granuloma evolution that distinguished active-disease and latent outcomes. Macaques (n ‫؍‬ 10) were infected with low-dose M. tuberculosis with FDG PET/CT performed during infection. At 24 weeks postinfection, animals were classified as having active disease (n ‫؍‬ 3) or latent infection (n ‫؍‬ 6), with one "percolator" monkey. Imaging characteristics (e.g., lesion number, metabolic activity, size, mineralization, and distribution of lesions) were compared among active and latent groups. As early as 3 weeks postinfection, more pulmonary granulomas were observed in animals that would later develop active disease than in those that would develop latent infection. Over time, new lesions developed in active-disease animals but not in latent animals. Granulomas and mediastinal lymph nodes from active-disease but not latent animals consistently increased in metabolic activity at early time points. The presence of fewer lesions at 3 weeks and the lack of new lesion development in animals with latent infection suggest that innate and rapid adaptive responses are critical to preventing active tuberculosis. A greater emphasis on innate responses and/or rapid recruitment of adaptive responses, especially in the airway, should be emphasized in newer vaccine strategies.

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Section: Discussionmentioning

confidence: 99%

Early Changes by ¹⁸ Fluorodeoxyglucose Positron Emission Tomography Coregistered with Computed Tomography Predict Outcome after Mycobacterium tuberculosis Infection in Cynomolgus Macaques

et al. 2014

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“…TB is today the second highest cause of death from infectious diseases after HIV/AIDS (1) and is the biggest killer of people infected with HIV (2). The World Health Organization's most recent global data (from 2005) show that every year 8 million people become ill with tuberculosis and 2 million people die of the disease.…”

Section: Introductionmentioning

confidence: 99%

TB database: an integrated platform for tuberculosis research

Reddy

Riley

Wymore

et al. 2009

Nucleic Acids Research

208

189

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The effective control of tuberculosis (TB) has been thwarted by the need for prolonged, complex and potentially toxic drug regimens, by reliance on an inefficient vaccine and by the absence of biomarkers of clinical status. The promise of the genomics era for TB control is substantial, but has been hindered by the lack of a central repository that collects and integrates genomic and experimental data about this organism in a way that can be readily accessed and analyzed. The Tuberculosis Database (TBDB) is an integrated database providing access to TB genomic data and resources, relevant to the discovery and development of TB drugs, vaccines and biomarkers. The current release of TBDB houses genome sequence data and annotations for 28 different Mycobacterium tuberculosis strains and related bacteria. TBDB stores pre- and post-publication gene-expression data from M. tuberculosis and its close relatives. TBDB currently hosts data for nearly 1500 public tuberculosis microarrays and 260 arrays for Streptomyces. In addition, TBDB provides access to a suite of comparative genomics and microarray analysis software. By bringing together M. tuberculosis genome annotation and gene-expression data with a suite of analysis tools, TBDB (http://www.tbdb.org/) provides a unique discovery platform for TB research.

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“…Overall, the amplification level of regions and the 4 Jundishapur J Microbiol. In Press(In Press):e13933.…”

Section: Discussionmentioning

confidence: 99%

“…Molecules recognized by TLR2, TLR4, and TLR5 include lipopeptides, lipopolysaccharides, and flagellins, respectively. Mycobacterium tuberculosis is identified by several TLRs, including TLR2/1/6, TLR9, and TLR4 (3)(4)(5). TLRs, especially TLR2, play an important role in the immune responses of patients with TB.…”

Section: Introductionmentioning

confidence: 99%

Arg677Trp and Arg753Gln Polymorphisms in TLR2 Genes Detected in Patients With Tuberculosis in Golestan Province, Iran

Davoodi

Ghaemi

Jamali

et al. 2018

Jundishapur J Microbiol

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Introduction: Toll-like receptors (TLRs), especially TLR2, play an important role in the immune responses of patients with tuberculosis (TB). The prevalence of TB is estimated 38.15 per 100,000 population in Golestan Province, Iran, which is higher than the rates reported in other provinces. Objectives: The current study aimed at detecting Arg677Trp and Arg753Gln polymorphisms in TLR2 genes detected in patients with TB in Golestan province. Methods: A total of 130 blood samples were collected from patients with sputum smear-positive TB, and 130 blood samples were collected from healthy individuals. Two polymorphisms of TLR2 gene, i e, Arg677Trp and Arg753Gln, were investigated via polymerase chain reaction (PCR)-single-strand conformation polymorphism (SSCP) and sequencing methods. Results: History of corticosteroid use was more frequently reported in patients, compared to the controls, while the frequency of Bacillus calmette-guerin (BCG) vaccination was more reported in controls. PCR-SSCP analysis of the TLR2 Arg677Trp region showed an almost identical pattern for patients and controls, while 2 SSCP patterns were observed in the amplicon, related to the Arg753Gln polymorphism. DNA sequencing for the Arg677Trp polymorphism showed a duplicated pseudogene, similar to the mutant sequence (C > T), as this polymorphism cannot be considered conclusive. The Arg753Gln polymorphism was not found in the samples, although nucleotide deletion (G) was detected at position 808 among the patients. Conclusions: The Arg753Gln polymorphism was not involved in susceptibility to TB in the current study population. The presence of pseudogenes in some genes such as TLR2 necessitates careful interpretation of such studies.

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Tuberculosis infection: Insight from immunogenomics

Cited by 25 publications

References 47 publications

Early Changes by ¹⁸ Fluorodeoxyglucose Positron Emission Tomography Coregistered with Computed Tomography Predict Outcome after Mycobacterium tuberculosis Infection in Cynomolgus Macaques

Early Changes by ¹⁸ Fluorodeoxyglucose Positron Emission Tomography Coregistered with Computed Tomography Predict Outcome after Mycobacterium tuberculosis Infection in Cynomolgus Macaques

TB database: an integrated platform for tuberculosis research

Arg677Trp and Arg753Gln Polymorphisms in TLR2 Genes Detected in Patients With Tuberculosis in Golestan Province, Iran

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Tuberculosis infection: Insight from immunogenomics

Cited by 25 publications

References 47 publications

Early Changes by 18 Fluorodeoxyglucose Positron Emission Tomography Coregistered with Computed Tomography Predict Outcome after Mycobacterium tuberculosis Infection in Cynomolgus Macaques

Early Changes by 18 Fluorodeoxyglucose Positron Emission Tomography Coregistered with Computed Tomography Predict Outcome after Mycobacterium tuberculosis Infection in Cynomolgus Macaques

TB database: an integrated platform for tuberculosis research

Arg677Trp and Arg753Gln Polymorphisms in TLR2 Genes Detected in Patients With Tuberculosis in Golestan Province, Iran

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Early Changes by ¹⁸ Fluorodeoxyglucose Positron Emission Tomography Coregistered with Computed Tomography Predict Outcome after Mycobacterium tuberculosis Infection in Cynomolgus Macaques

Early Changes by ¹⁸ Fluorodeoxyglucose Positron Emission Tomography Coregistered with Computed Tomography Predict Outcome after Mycobacterium tuberculosis Infection in Cynomolgus Macaques