Paternal and maternal preconception urinary phthalate metabolite concentrations and child behavior

Messerlian, Carmen; Bellinger, David C.; Mínguez-Alarcón, Lidia; Romano, Megan E.; Ford, Jennifer B.; Williams, Paige L.; Calafat, Antònia M.; Hauser, Russ; Braun, Joseph M.

doi:10.1016/j.envres.2017.07.032

Cited by 36 publications

(24 citation statements)

References 64 publications

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“…We also observed sex-specific associations and heterogeneous results based on maternal prenatal vitamin intake. Our results are additional evidence for sex dimorphism of childhood neurodevelopment associated with prenatal phthalate exposures [ 58 , 63 – 66 ]. We additionally found hypothesized positive associations between prenatal concentrations of three phthalate metabolites (MCPP, MCOP, MCNP) and an increased risk of Non-TD among mothers who did not take prenatal vitamins, whereas inverse associations were found between prenatal concentrations of three phthalate metabolites (MiBP, MCPP, MCOP) and an increased risk of ASD among mothers taking prenatal vitamins.…”

Section: Resultssupporting

confidence: 53%

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Prenatal exposure to phthalates and autism spectrum disorder in the MARBLES study

et al. 2018

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BackgroundEvidence from experimental and observational studies suggests that prenatal phthalate exposures may be associated with autism spectrum disorder (ASD). We examined whether prenatal phthalate exposures were associated with an increased risk of ASD.MethodsWe quantified 14 metabolites of eight phthalates in 636 multiple maternal urine samples collected during 2nd and 3rd trimesters of pregnancy from 201 mother-child pairs in MARBLES (Markers of Autism Risk in Babies – Learning Early Signs), a high-risk ASD longitudinal cohort. At 3 years old, children were clinically assessed for ASD and classified into three diagnostic categories: ASD (n = 46), non-typical development (Non-TD, n = 55), and typical development (TD, n = 100). We used multinomial logistic regression to evaluate the association of phthalate metabolite concentrations with ASD and Non-TD.ResultsMost associations of phthalate biomarkers with both ASD and Non-TD were null, with the exception that monoethyl phthalate (MEP) was significantly associated with an increased risk of Non-TD (per 2.72-fold relative increase in concentration: Relative risk ratio (RRR) = 1.38; 95% confidence interval (CI): 1.01, 1.90). When stratified by prenatal vitamin use during the first month of pregnancy, among mothers who took vitamins, ASD risk was inversely associated with mono-isobutyl phthalate (MiBP, RRR = 0.44; 95% CI: 0.21, 0.88), mono(3-carboxypropyl) phthalate (MCPP, RRR = 0.41; 95% CI: 0.20, 0.83) and mono-carboxyisooctyl phthalate (MCOP, RRR = 0.49; 95% CI: 0.27, 0.88), but among mothers who did not take prenatal vitamins, Non-TD risk was positively associated with MCPP (RRR = 5.09; 95% CI: 2.05, 12.6), MCOP (RRR = 1.86; 95% CI: 1.01, 3.39), and mono-carboxyisononyl phthalate (MCNP, RRR = 3.67; 95% CI: 1.80, 7.48). When stratified by sex, among boys, MEP, monobenzyl phthalate, MCPP, MCNP, and sum of di(2-ethylhexyl) phthalate metabolites (ΣDEHP) were positively associated with Non-TD risk, but associations with ASD were null. Among girls, associations with both ASD and Non-TD were null.ConclusionsOur study showed that phthalate exposures in mid- to late pregnancy were not associated with ASD in children from this high-risk ASD cohort. Further studies should be conducted in the general population without high-risk genes to confirm our findings.Electronic supplementary materialThe online version of this article (10.1186/s12940-018-0428-4) contains supplementary material, which is available to authorized users.

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Section: Resultssupporting

confidence: 53%

“…When analyses were stratified by child’s sex, we observed opposite directions of RRRs of ASD between girls and boys for four metabolites (i.e., MEP, MBP, MBzP, MCNP) and ΣDEHP. This is additional evidence for sex dimorphism of childhood neurodevelopment associated with prenatal phthalate exposures [ 58 , 63 – 66 ].…”

Section: Discussionmentioning

confidence: 97%

Prenatal exposure to phthalates and autism spectrum disorder in the MARBLES study

et al. 2018

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“…[ 23 ] The physiological and psychosocial effects of BPA in children were getting inordinate amounts of this scholar. [ 24 , 25 ] John D. Meeker came from University of Michigan, United States, ranked 2nd in the number of articles published. Most articles involved the relationship between BPA and thyroid hormones in pregnant women, children and adolescents.…”

Section: Discussionmentioning

confidence: 99%

Bisphenol A and thyroid hormones

Yuan¹,

Wang²,

Zhang³

et al. 2020

Medicine

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Bisphenol A (BPA) is a well-known endocrine-disrupting chemical which can cause potential health risks and interfere with thyroid hormones through multiple avenues. This study aimed to evaluate the hotspots and emerging trends on BPA and thyroid hormones by using a bibliometric method. Publications related on BPA and thyroid hormones were downloaded from Science Citation Index-Expanded database. Annual outputs, high yield journals, countries, institutions, authors and their cited times were summarized. In addition, keywords co-occurrence, burst references and citation networks were bibliometric analyzed. From 2000 to 2019, 418 articles were published. Both of the Environment International and Environmental Health Perspectives , United States, Chinese Academy of Sciences and Antonia M. Calafat were the most recorded journals, countries, institutions and authors, respectively. The main research area was Toxicology. In addition of the retrieve term “bisphenol-a” and “thyroid-hormone”, “in-vitro”, “exposure” and “endocrine disruptors”, were the hotspot keywords and “triclosan”, “oxidative stress” and “united-states” were the most recent trends keywords. “Thyroid hormone action is disrupted by Bisphenol A as an antagonist” published on The Journal of Clinical Endocrinology & Metabolism by Kenji Moriyama in 2002 got both the highest burst score and citation score. Six groups were clustered and the mechanism of BPA's effect on thyroid hormones, and the exposure of BPA and potential risks in children and pregnant women were the two main large fields. The number of publications in the field of BPA and thyroid hormones has increased tremendously since 2000. The research hotspot ranged from mechanism researches in animal models to epidemiological studies. “Thyroid hormone action is disrupted by bisphenol A as an antagonist” of Kenji Moriyama provided important building blocks in the field. The impact of BPA on thyroid hormones, especially pregnant women and children, was the latest research frontiers and might be the future direction of this filed in the following years.

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“…Sometimes, it is inevitable that exposed partners reproduce only with control (e.g. human medical studies [72,73];), precluding analyses of the effect of combined exposure. The most informative is a two-by-two factorial design (also known as North Carolina II).…”

Section: Mothermentioning

confidence: 99%

Mapping the past, present and future research landscape of paternal effects

et al. 2020

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Background Although in all sexually reproducing organisms an individual has a mother and a father, non-genetic inheritance has been predominantly studied in mothers. Paternal effects have been far less frequently studied, until recently. In the last 5 years, research on environmentally induced paternal effects has grown rapidly in the number of publications and diversity of topics. Here, we provide an overview of this field using synthesis of evidence (systematic map) and influence (bibliometric analyses). Results We find that motivations for studies into paternal effects are diverse. For example, from the ecological and evolutionary perspective, paternal effects are of interest as facilitators of response to environmental change and mediators of extended heredity. Medical researchers track how paternal pre-fertilization exposures to factors, such as diet or trauma, influence offspring health. Toxicologists look at the effects of toxins. We compare how these three research guilds design experiments in relation to objects of their studies: fathers, mothers and offspring. We highlight examples of research gaps, which, in turn, lead to future avenues of research. Conclusions The literature on paternal effects is large and disparate. Our study helps in fostering connections between areas of knowledge that develop in parallel, but which could benefit from the lateral transfer of concepts and methods.

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Paternal and maternal preconception urinary phthalate metabolite concentrations and child behavior

Cited by 36 publications

References 64 publications

Prenatal exposure to phthalates and autism spectrum disorder in the MARBLES study

Prenatal exposure to phthalates and autism spectrum disorder in the MARBLES study

Bisphenol A and thyroid hormones

Mapping the past, present and future research landscape of paternal effects

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