Paternal Age and Spontaneous Abortion

Kleinhaus, Karine; Perrin, Mary; Friedlander, Y; Paltiel, Ora; Malaspina, Dolores; Harlap, Susan

doi:10.1097/01.aog.0000224606.26514.3a

Cited by 133 publications

(96 citation statements)

References 38 publications

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“…This result is in line with previous studies showing an association between advanced paternal age and some congenital malformations [6,25,28,31]. Several studies have also shown that fetal death correlates with paternal age [1,9,15,19,24].…”

Section: Discussionsupporting

confidence: 92%

“…Advanced paternal age has been associated with a higher risk of spontaneous abortions [9,15,24], stillbirth [1,19], preterm birth [2,30], congenital malformations [25,28,31], childhood cancer [10,29], epilepsy [26], autism [17,21], and schizophrenia [18,23] in the offspring. The biological mechanisms behind these associations are unknown but may be related to de novo mutations and epigenetic changes in male germ cells with short and long term health consequences for the offspring.…”

Section: Introductionmentioning

confidence: 99%

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Paternal age and mortality in children

et al. 2008

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Paternal age and mortality in children

et al. 2008

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“…The most compelling indication that paternal age may affect embryo quality is data on miscarriage. In general, the consensus from the available data is that advanced paternal age is a risk factor for miscarriage though no real mechanisms for this fi nding have been elucidated (Kleinhaus et al 2006 ;Slama et al 2005 ). Other studies evaluating ART with donor eggs (to completely remove the infl uence of maternal factors) found no associations between paternal age and risk of miscarriage (Begueria et al 2014 ).…”

Section: Embryo Quality Pregnancy Outcomes and Offspring Healthmentioning

confidence: 99%

The Sperm Epigenome, Male Aging, and Potential Effects on the Embryo

Jenkins

Aston

Meyer

et al. 2015

Advances in Experimental Medicine and Biology

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The effect of paternal aging on fertility, embryo quality, and offspring health is an important area of study that has received far less attention than the age effect in women. This is, in part, due to the fact that in females there are dramatic alterations to fertility and pregnancy outcomes that abruptly occur as a female ages. Such abrupt alterations to pregnancy success and/or embryonic and offspring health are not seen in males. Instead, there are subtle alterations to pregnancy success and offspring phenotypes that occur as a man ages. It is believed that, at least in part, these alterations can be explained by perturbations to the sperm epigenome that occur over time. This chapter will explore the effect of aging on the sperm epigenome and the potential impacts these perturbations may have on embryonic development and ultimately offspring health.

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“…In addition, serum steroid levels decrease with advancing age, reflecting altered hypothalamic-pituitary axis regulation and decreased testicular function (12). Advanced paternal age has been linked to an increased risk of miscarriage (13), a higher rate of obstetric complications such as preeclampsia (14) and disorders in the offspring, including low birth weight (15), impaired neurocognitive outcomes (16), Down syndrome (17), epilepsy (18), schizophrenia (19), diabetes mellitus (20), and breast cancer (21).…”

mentioning

confidence: 99%