The effect of paternal age on assisted reproduction outcome

Dain, Lena; Auslander, Ron; Dirnfeld, Martha

doi:10.1016/j.fertnstert.2010.08.029

Cited by 141 publications

(132 citation statements)

References 57 publications

(77 reference statements)

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“…Age of the father has been implicated in reducing the rates of ART fertilization, implantation, pregnancy, and live birth [10,21,22] although these results are not found consistently [9]. Other studies have linked paternal age to increased miscarriage rates [8], as well as birth defects and autism [11-15, 21, 23].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of father’s age in fertile, subfertile, and assisted reproductive technology pregnancies: A population based cohort study

Stern

Luke

Hornstein

et al. 2014

J Assist Reprod Genet

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Purpose To compare ages of mothers and of fathers at delivery in couples who are fertile, subfertile, and subfertile treated with assisted reproductive technology (ART) and to characterize birth outcomes in the ART population according to paternal age. Methods Live birth deliveries in Massachusetts between July, 2004 and December, 2008 were identified from vital records and categorized by maternal fertility status and treatment as ART, subfertile or fertile. The ART births were linked to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) database to obtain cycle-specific treatment data. Parental ages were obtained from birth certificates. Age of mothers and fathers were compared using ANOVA for continuous measures and χ 2 for categories. Risks of prematurity (<37 weeks), low birthweight (<2,500 g), and low birthweight z-score (small for gestatational age, SGA) were modeled using logistic regression by categories of paternal age as adjusted odds ratios and 95 % CI. Results The study population included 9,092 ART, 6,238 subfertile, and 318,816 fertile deliveries. Paternal ages in the ART and subfertile groups were similar and differed significantly from those of the fertile group. Maternal age in the ART and subfertile groups averaged 5-6 years older than their fertile counterparts and fathers averaged 4-5 years older with twice as many being older than 37. The risks for prematurity, low birthweight and SGA did not increase with increasing paternal age. Conclusions Fathers in ART-treated and subfertile couples are older than in their fertile counterparts. Older paternal age was not assoicated with increased risk for prematurity, low birthweight, or SGA.

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Section: Discussionmentioning

confidence: 99%

“…A paternal age >40 may contribute to increased miscarriage rates, particularly when the woman is also of advanced age [8] but studies differ on the effect of paternal age on ART success rates [9,10]. In addition, rates of birth defects and autism may also be increased with advanced paternal age [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

The effect of father’s age in fertile, subfertile, and assisted reproductive technology pregnancies: A population based cohort study

Stern

Luke

Hornstein

et al. 2014

J Assist Reprod Genet

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“…The adverse effects of advanced maternal aging on reproductive potential have been well documented [98]; however, studies examining the effect of paternal aging on fertilization capacity are insufficient and the results are conflicting. Although motility, vitality, and normal morphology appear to decrease with aging, there is no clinical finding for an alteration in fertilization capacity in older men [99].…”

Section: Fertilization Capacitymentioning

confidence: 99%

Effects of aging on the male reproductive system

Güneş

Hekim

Arslan

et al. 2016

J Assist Reprod Genet

186

118

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The study aims to discuss the effects of aging on the male reproductive system. A systematic review was performed using PubMed from 1980 to 2014. Aging is a natural process comprising of irreversible changes due to a myriad of endogenous and environmental factors at the level of all organs and systems. In modern life, as more couples choose to postpone having a child due to various socioeconomic reasons, research for understanding the effects of aging on the reproductive system has gained an increased importance. Paternal aging also causes genetic and epigenetic changes in spermatozoa, which impair male reproductive functions through their adverse effects on sperm quality and count as, well as, on sexual organs and the hypothalamic-pituitarygonadal axis. Hormone production, spermatogenesis, and testes undergo changes as a man ages. These small changes lead to decrease in both the quality and quantity of spermatozoa. The offspring of older fathers show high prevalence of genetic abnormalities, childhood cancers, and several neuropsychiatric disorders. In addition, the latest advances in assisted reproductive techniques give older men a chance to have a child even with poor semen parameters. Further studies should investigate the onset of gonadal senesce and its effects on aging men.

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“…A recent in-depth analysis by Dain et al 57 does provide a comprehensive summary of the current literature. The authors examined 10 studies that examined APA and the effects on fertilization and pregnancy rates, implantations, miscarriages and live births.…”

Section: Effect Of Paternal Age On Reproductive Successmentioning

confidence: 99%

The effects of advanced paternal age on fertility

Kovac¹,

Addai²,

Smith³

et al. 2013

Asian J Androl

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Modern societal pressures and expectations over the past several decades have resulted in the tendency for couples to delay conception. While women experience a notable decrease in oocyte production in their late thirties, the effect of age on spermatogenesis is less well described. While there are no known limits to the age at which men can father children, the effects of advanced paternal age are incompletely understood. This review summarizes the current state of knowledge regarding advanced paternal age and its implications on semen quality, reproductive success and offspring health. This review will serve as a guide to physicians in counseling men about the decision to delay paternity and the risks involved with conception later in life.

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The effect of paternal age on assisted reproduction outcome

Cited by 141 publications

References 57 publications

The effect of father’s age in fertile, subfertile, and assisted reproductive technology pregnancies: A population based cohort study

The effect of father’s age in fertile, subfertile, and assisted reproductive technology pregnancies: A population based cohort study

Effects of aging on the male reproductive system

The effects of advanced paternal age on fertility

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