Paternal age and autism are associated in a family-based sample

Cantor, Rita M.; Yoon, Ji-Young; Furr, Jami M.; Lajonchere, Clara

doi:10.1038/sj.mp.4001966

Cited by 36 publications

(19 citation statements)

References 9 publications

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“…There are now replicated findings that children born to older fathers have an increased rate of autism (Reichenberg et al 2006;Croen et al 2007;Cantor et al 2007). Less certainly, this may also apply to older mothers.…”

Section: Raised Parental Agementioning

confidence: 78%

Progress in Understanding Autism: 2007–2010

Rutter

2011

J Autism Dev Disord

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Scientific progress is discussed in relation to clinical issues; genetic issues; environmental issues; and the state of play on psychological treatments. It is concluded that substantial gains in knowledge have been achieved during the last 3 years, and there have been some unexpected findings, but major puzzles remain. We should be hopeful of ever greater gains in the years ahead, but both prevention and cure remain elusive.

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Section: Raised Parental Agementioning

confidence: 78%

Progress in Understanding Autism: 2007–2010

Rutter

2011

J Autism Dev Disord

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“…Currently, it is estimated that one out of 88 children has an ASD, representing a 78% increase over the past 6 years [7]. This drastic increase is most likely due to sociocultural factors rather than biological factors, including age at diagnosis, changing diagnostic criteria, and broader inclusion rates, although genetic and environmental factors cannot be ruled out [8-11]. …”

mentioning

confidence: 99%

Autism genetics: searching for specificity and convergence

2012

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“…A consistent fi nding in the analyses of these three databases is that older fathers are more likely to have children with ASD. In the AGRE database, which is designed for genetic but not epidemiologic studies, the related fi nding that children with autism are more likely to have older fathers [49] was found, further supporting this association. Factors contributing to the association of paternal age at conception with ASD have been postulated, and further investigations are likely to identify the pertinent ones.…”

Section: Strategies For Reducing Genetic Heterogeneity Are Effectivementioning

confidence: 75%