Patent foramen ovale and stroke in childhood: A systematic review of the literature

Khan, Rubeena; Chan, Anthony; Mondal, Tapas; Paes, Bosco

doi:10.1016/j.ejpn.2016.04.012

Cited by 25 publications

(24 citation statements)

References 87 publications

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“…The American College of Chest Physicians evidence-based clinical practice guidelines recommend surgical closure of a PFO RTLS if an AIS occurs secondary to cardio-embolic causes but the recommendation stems from low or very low-quality evidence 2,21 .…”

Section: Discussionmentioning

confidence: 99%

“…Stroke in association with a PFO may be due to paradoxical embolization via a right to left intracardiac shunt 2 , but the exact contribution of PFO to stroke or stroke recurrence in childhood remains unclear. Paradoxical embolism from a PFO as a cause of transient ischemic attack or stroke is a diagnosis of exclusion.…”

Section: Discussionmentioning

confidence: 99%

“…A patent foramen ovale (PFO) is a normal connection between the right and left atria, caused by the incompetence of the fossa ovalis valve during fetal life 2 . The shunt is usually right to- left despite the gradient pressure between the atria.…”

Section: Introductionmentioning

confidence: 99%

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Recurrent arterial ischemic strokes in a patient with patent foramen ovale and ductus arteriosus: Presentation of our management and review of the literature

Panagopoulos

Loukopoulou

Karanasios

et al. 2019

gcsp

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Ischemic stroke in children is a relatively rare entity, relative to the adult population. The most common potential risk factors include cardiac embolism, prothrombotic states and vasculopathies. The diagnosis is concerning for the need to identify the underlying cause. Treatment of the proximate source of ischemia can often protect against future events.We present the case of a 7-year-old patient who initially presented with an ischemic brain insult which was repeated, despite the initiation of anticoagulation therapy. The investigation revealed patent foramen ovale and patent ductus arteriosus and because of the recurrent ischemic ictuses, transcatheter closure of both defects was decided. A brief description of the literature is also presented.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Recurrent arterial ischemic strokes in a patient with patent foramen ovale and ductus arteriosus: Presentation of our management and review of the literature

Panagopoulos

Loukopoulou

Karanasios

et al. 2019

gcsp

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“…Most patients were young and have no medical history of hypertension, diabetes or hyperlipidemia, and routine imaging examination also failed to detect significant vascular abnormalities 1 . Currently, patent foramen ovale (PFO) has been reported to be strongly associated with a number of diseases, including cryptogenic stroke, 2 transient ischemic attack (TIA), 3 migraine, 4 peripheral arterial embolism, and decompression sickness 5…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of the diagnostic value of several methods for the diagnosis of patent foramen ovale

et al. 2021

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Background: In recent years, patent foramen ovale (PFO) has been reported to be strongly associated with embolic strokes of undetermined source (ESUS), including cryptogenic stroke, transient ischemic attack (TIA), migraine, and so on.The aim of this research was to compare the sensitivity and positive predictive value of contrast transcranial Doppler (c-TCD), contrast-transthoracic echocardiography (c-TTE) versus contrast-transesophageal echocardiography (c-TEE), to nd which is the best method to diagnose patent foramen ovale (PFO), provides reference for the further improvement of clinical.Methods: We investigated 161 patients who suffered from migraine, cryptogenic stroke, TIA, and cerebral infarction of unknown cause, all patients underwent the transcatheter examination, and put the results of the right heart catheterization (RHC) as the gold standard for PFO diagnosis. A chi-square test was used to compare the sensitivity and speci city between the three methods. A P value of <0.05 indicated statistical signi cance.Results: The present study revealed that c-TTE with the Valsalva maneuver yielded a higher sensitivity in detecting PFO-RLS, but the rate of misdetection might be higher than c-TCD.Conclusions: For the suspected patients, can examine with c-TCD rst, if we get the positive results, then c-TTE and c-TEE should be taking to further con rmed. These ndings may be helpful in the diagnosis of patent foramen ovale in practice.

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“…While there is some evidence suggesting an important role of right-to-left shunting across an atrial defect, particularly among patients with prothrombotic conditions or cryptogenic stroke [10], the role of device closure remains undefined due to lack of sufficient evidence [11].…”

Section: Introductionmentioning

confidence: 99%

Cerebral hemorrhagic infarction as the initial manifestation of deep venous thrombosis in a child with patent foramen ovale: A case report

Panagopoulos¹,

Loukopoulou²,

Markogiannakis³

et al. 2017

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations.IJCRI publishes Review Articles, Case Series, Case Reports, Case in Images, Clinical Images and Letters to Editor. Website: www.ijcasereportsandimages.comCerebral hemorrhagic infarction as the initial manifestation of deep venous thrombosis in a child with patent foramen ovale: A case report Dimitrios Panagopoulos, Sofia Loukopoulou, Georgios Markogiannakis, Nikos Eleftherakis ABSTRACT Introduction: Arterial ischemic stroke (AIS), with an estimated incidence of 1.1-4.3 per 100,000, is an important cause of morbidity and mortality in children and the recurrence risk is high. Case Report: We present the case of an 11-year-old child who presented with a symptomatology of acute ischemic stroke of unknown etiology. The radiological investigation did not reveal any underlying brain abnormality that could cause the event. The diagnostic work up included an echocardiogram, which revealed a thrombus in the right atrium, in conjunction with a patent foramen ovale. The patient was initiated immediately on anticoagulation therapy with low molecular weight heparin and warfarin, but two days later she suffered pulmonary emboli, diagnosed with spiral thorax computed tomography scan. An ultrasound study of the vessels of the lower extremities revealed deep venous thrombosis, which was considered to be the underlying causative mechanism. Conclusion: To the best of our knowledge, this is the first documented case of right atrial thrombus resulting from deep venous thrombosis in a pediatric patient with patent foramen ovale and associated ischemic stroke event. A discussion regarding the definition of cryptogenic stroke, its etiology and relationship with deep venous thrombosis and the currently proposed therapy, follows.

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Patent foramen ovale and stroke in childhood: A systematic review of the literature

Cited by 25 publications

References 87 publications

Recurrent arterial ischemic strokes in a patient with patent foramen ovale and ductus arteriosus: Presentation of our management and review of the literature

Recurrent arterial ischemic strokes in a patient with patent foramen ovale and ductus arteriosus: Presentation of our management and review of the literature

Comparative analysis of the diagnostic value of several methods for the diagnosis of patent foramen ovale

Cerebral hemorrhagic infarction as the initial manifestation of deep venous thrombosis in a child with patent foramen ovale: A case report

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