Patent ductus venosus in an infant with direct hyperbilirubinemia

Kamali, Leila; Moradi, Maryam; Ebrahimian, Shadi; Esfahani, Mahsa Masjedi; Jafarpishe, Mohamad Saleh

doi:10.1002/ccr3.2266

Cited by 6 publications

(12 citation statements)

References 13 publications

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“…PDV is more common in boys [4,9] , with a male to female ratio of 7:2 in this study. PDV was classi ed as a type of intrahepatic portosystemic shunt (PSS).…”

Section: Discussionmentioning

confidence: 47%

“…In the younger patients, jaundice was often the initial presentation, while in the older patients, repeated pulmonary in ammation was more common. Previous reports suggest PDV is a very rare cause of cholestatic jaundice [9] . Symptoms of patients with PDV can appear at different ages, which can be severe in infancy or initially asymptomatic and develop slowly with age.…”

Section: Clinical Symptoms and Laboratory Testsmentioning

confidence: 98%

“…previously [4,9,17] . In this study, the incidence of hypoxemia was 56%, hyperbilirubinemia was 78%, and coagulation dysfunction was 67%.…”

Section: Clinical Symptoms and Laboratory Testsmentioning

confidence: 99%

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The Clinical and Imaging Findings of Patent Ductus Venosus in Children: A Retrospective Analysis

Xiang

Peng

et al. 2021

Preprint

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Purpose Patent ductus venosus (PDV) was a rare congenital portosystemic shunt, and few studies have been reported to date. The purpose of this study was to investigate the clinical and imaging findings to improve the recognition of PDV. Materials and Methods Medical records of 9 patients with PDV in Hunan Children’s Hospital from May 2013 to December 2020 were retrospectively reviewed. The clinical, and laboratory tests data were extracted from the electronic medical records. Two pediatric radiologists evaluated all imaging examinations of the patients.Results 9 patients with PDV were reviewed, including 7 males and 2 females, aged from 16 days to 16.5 years, median age was 1.6 years. PDV diameter ranged from 4.0mm to 17.5mm. The initial clinical presentations of PDV were varied, but jaundice and respiratory symptoms were the most common. Laboratory tests showed that 5/9 cases had hypoxemia, 2/9 had hyperammonemia, 7/9 had hyperbilirubinemia, 6/9 had abnormal coagulation function, 4/9 had abnormal myocardial enzymes, 8/9 had hepatic dysfunction, and 3/9 had renal dysfunction. The direct imaging sign of PDV was a vascular structure connecting the left branch of portal vein(LPV) to the inferior vena cava(IVC), running in the depth of the Arantius sulcus. The secondary imaging findings were as follows: All the patients had enlarged liver, especially the left lobe, and one of the patients presented with diffuse nodules in the liver. 3 patients presented with hypoperfusion in right lobe of liver. The spleen was enlarged in 8 cases but shrank in one. Dilated LPV and atrophic right branch of portal vein (RPV) were observed in all patients. The main portal vein (MPV) was dilated in 8 cases and shrank in one. Dilated right heart and pulmonary artery were observed in all cases. Abnormal renal imaging was observed in 2 patients. The complications and coexistent malformations were as follows: Brain MRI indicated hepatic encephalopathy in 4 cases. 7/9 patients were combined with other malformations, and the most common coexistent malformations were congenital heart disease (CHD) and vascular abnormalities, with 5 and 6 cases respectively. Conclusions PDV was a rare vascular malformation that can lead to multi-system lesions. The clinical presentations and laboratory findings were diverse. The diagnosis of PDV mainly depends on imaging examinations, and it is important to evaluate the secondary imaging changes. Complications and coexistent malformations were common, and we need to prevent omissions during the imaging evaluations.

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“…PDV is more common in boys [4,9] , with a male to female ratio of 7:2 in this study. PDV was classi ed as a type of intrahepatic portosystemic shunt (PSS).…”

Section: Discussionmentioning

confidence: 47%

Section: Clinical Symptoms and Laboratory Testsmentioning

confidence: 98%

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The Clinical and Imaging Findings of Patent Ductus Venosus in Children: A Retrospective Analysis

Xiang

Peng

et al. 2021

Preprint

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“…Possible symptoms are: increased liver enzymes, increased levels of direct bilirubin, galactosemia, hyperammonemia and liver dysfunction up to and including liver failure and increased cardiac stress [27,28]. An association with cardiac defects, especially pulmonary arterial hypertension, is also observed in up to 25 % of cases [27].…”

Section: Persistent DVmentioning

confidence: 99%

“…Hierbei mögliche Begleitsymptome sind: erhöhte Leberenzyme, erhöhte Werte für das direkte Bilirubin, Galaktosämie, Hyperammonämie sowie Leberfunktionsstörungen bis hin zum Leberversagen und eine vermehrte kardiale Belastung [27,28]. Auch eine Assoziation mit Herzvitien und insbesondere einer pulmo-nal-arteriellen Hypertonie ist in bis zu 25 % der Fälle zu beobachten [27].…”

Section: Persistierender DVunclassified

The Ductus Venosus

Born

2020

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Background the ductus venosus (DV) is not well known in general radiology, but it plays a role in the daily work of pediatric radiologists. Consequently all general radiologists who also care for a pediatric department should be familiar with the physiological and pathological findings related to the DV. Methods: Literature research in Medline, using the keywords “ductus venosus” and “umbilical vein catheter”. Results and conclusions In the first weeks of life the DV is regularly still patent. It should be recognized as DV and not be mistaken for a pathological portosystemic shunt.The ductus venosus is the lead structure for umbilical vein catheters. Radiologists should be able to assess the correct catheter position. Radiologically important findings of an umbilical vein catheter are mainly malposition and intrahepatic extravasation. Agenesis of the DV can lead to intra- or extrahepatic compensatory portosystemic shunts, in which as well as in the case of persistent patency of the DV, there may be the necessity for radiological-interventional or surgical occlusion. Key points: Citation Format

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An analysis of cardiology consultation requests in infants presented to the pediatric emergency department of a tertiary children’s hospital

Öztürk,

Güneylioğlu,

Yaradilmiş

et al. 2023

Postgraduate Medicine

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Patent ductus venosus in an infant with direct hyperbilirubinemia

Abstract: Patent ductus venosus is caused by a defect in obliteration of ductus venosus after birth. Ductus venosus connects umbilical vein and inferior vena cava during fetal period. Patent ductus venosus is a very rare cause of cholestatic jaundice.

Cited by 6 publications

References 13 publications

The Clinical and Imaging Findings of Patent Ductus Venosus in Children: A Retrospective Analysis

The Clinical and Imaging Findings of Patent Ductus Venosus in Children: A Retrospective Analysis

The Ductus Venosus

An analysis of cardiology consultation requests in infants presented to the pediatric emergency department of a tertiary children’s hospital

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