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QIAN, Zhongshu; Campbell, Duncan

doi:10.1163/9789004270213

Cited by 7 publications

(1 citation statement)

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“…The title compounds showed inhibitory activities with IC 50 of 0.001-10 μM against EGFR. In addition, quainazoline derivative 49 Figure 27 produced by Wei et al [85] was an active ingredient for the inhibition of EGFR tyrosine kinase activity of the receptor, to reduce the phosphorylation of tyrosine residues on the substrates of the kinases contained, so that for the treatment of various diseases such as ERBB family receptor tyrosine kinase expression related cancer. In biological assay test, these derivatives showed inhibitory activity with IC 50 of 0.1-10 μM against EGFR.…”

Section: Chemistryselectmentioning

confidence: 99%

Epidermal Growth Factor Receptor Inhibiting 4‐Aminoquinazolines as Promising Anticancer Agents: A Patent Review (2000‐Present)

Patel,

Mistry,

Gujarati

et al. 2023

ChemistrySelect

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Cancer is now recognized as a major threat to global health and a notable cause of human mortality. Rapid cell multiplication abilities and the unchecked cell expansion that develops from a single cell define it. The epidermal growth factor receptor is a member of the ERBB family of receptors (ERBB‐1/2/3/4), and cancer can occur due to EGFR mutations. A lot of research is now being done on 4‐aminoquinazolines to suppress EGFR. With FDA‐approved medications based on the 4‐aminoquinazoline core already in use, we think that this core holds a lot of promise for a novel type of cancer therapy with significant therapeutic benefits. In this patent review, we have surveyed a huge number of patents reported (2000‐present) involving 4‐aminoquinazoline core as an anticancer agent targeting EGFR. We attempt here, with a huge body of literature based on this core, to update researchers about the latest EGFR‐targeted developments utilizing 4‐aminoquinazolines, which will provide support for the development of novel kinase‐targeted cancer therapies.

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Section: Chemistryselectmentioning

confidence: 99%

Epidermal Growth Factor Receptor Inhibiting 4‐Aminoquinazolines as Promising Anticancer Agents: A Patent Review (2000‐Present)

Patel,

Mistry,

Gujarati

et al. 2023

ChemistrySelect

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Lin Shu and the Routes of World Literature

Hill¹

2019

A Companion to World Literature

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Lin Shu (1852–1924) and his collaborators served as an important conduit for world literature in early twentieth‐century China, rendering the work of authors such as Harriet Beecher Stowe, Charles Dickens, and Alexandre Dumas into Chinese for the first time. His ideas about the role of translated literature, as well as younger intellectuals' disavowal of his work, offer new lines of comparative research on translation in China and other parts of the world.

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Introduction—Environment, Modernization, and Development in East Asia: Perspectives from Environmental History

Beattie¹,

Liu²

2016

Environment, Modernization and Development in East Asia

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Cited by 7 publications

References 0 publications

Epidermal Growth Factor Receptor Inhibiting 4‐Aminoquinazolines as Promising Anticancer Agents: A Patent Review (2000‐Present)

Epidermal Growth Factor Receptor Inhibiting 4‐Aminoquinazolines as Promising Anticancer Agents: A Patent Review (2000‐Present)

Lin Shu and the Routes of World Literature

Introduction—Environment, Modernization, and Development in East Asia: Perspectives from Environmental History

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