Patch Testing for Noncontact Dermatitis: The Atopy Patch Test for Food and Inhalants

Wollenberg, Andreas; Vogel, S.

doi:10.1007/s11882-013-0368-6

Cited by 30 publications

(32 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A positive test will reflect sensitization, but may have poor correlation with clinical allergic responses . In addition, atopy patch tests proved to be useful for studying delayed food‐related skin responses …”

Section: Avoidance Strategies On the Basis Of Allergy Diagnosismentioning

confidence: 99%

“…The availability of standardized aeroallergen preparations for APT from different manufacturers has declined during the last 5 years. The reimbursement situation for APT is inappropriate in most countries, which further reduces its routine use . As still no feasible standard procedure for provocation of eczema in aeroallergen‐mediated AD exists, specific avoidance strategies should be considered in highly sensitized patients with chronic moderate to severe disease (Table ).…”

Section: Avoidance Strategies On the Basis Of Allergy Diagnosismentioning

confidence: 99%

“…32 In addition, atopy patch tests proved to be useful for studying delayed food-related skin responses. 33 Skin prick test (SPT) with food allergens (i.e. cow 0 s milk, eggs, wheat, soy, peanut) is suggested in children <5 years with moderate to severe AD, that is persistent in spite of optimized management and topical therapy.…”

Section: Food Allergensmentioning

confidence: 99%

See 2 more Smart Citations

ETFAD/EADV Eczema task force 2015 position paper on diagnosis and treatment of atopic dermatitis in adult and paediatric patients

Wollenberg

Oranje²,

Deleuran

et al. 2016

Acad Dermatol Venereol

358

488

View full text Add to dashboard Cite

Atopic dermatitis (AD) is a clinically defined, highly pruritic, chronic inflammatory skin disease of children and adults. The diagnosis is made using evaluated clinical criteria. Disease activity is best measured with a composite score assessing both objective signs and subjective symptoms, such as SCORAD. The management of AD must consider the clinical and pathogenic variabilities of the disease and also target flare prevention. Basic therapy includes hydrating topical treatment, as well as avoidance of specific and unspecific provocation factors. Anti-inflammatory treatment of visible skin lesions is based on topical glucocorticosteroids and the topical calcineurin inhibitors tacrolimus and pimecrolimus. Topical calcineurin inhibitors are preferred in sensitive locations. Tacrolimus and mid-potent steroids are proven for proactive therapy, which is long-term intermittent anti-inflammatory therapy of the frequently relapsing skin areas. Systemic anti-inflammatory or immunosuppressive treatment is indicated for severe refractory cases. Biologicals targeting key mechanisms of the atopic immune response are promising emerging treatment options. Microbial colonization and superinfection may induce disease exacerbation and can justify additional antimicrobial treatment. Systemic antihistamines (H1R-blockers) may diminish pruritus, but do not have sufficient effect on lesions. Adjuvant therapy includes UV irradiation, preferably UVA1 or narrow-band UVB 311 nm. Dietary recommendations should be patient specific and elimination diets should only be advised in case of proven food allergy. Allergen-specific immunotherapy to aeroallergens may be useful in selected cases. Psychosomatic counselling is recommended to address stress-induced exacerbations. 'Eczema school' educational programmes have been proven to be helpful for children and adults.

show abstract

Section: Avoidance Strategies On the Basis Of Allergy Diagnosismentioning

confidence: 99%

Section: Avoidance Strategies On the Basis Of Allergy Diagnosismentioning

confidence: 99%

See 1 more Smart Citation

ETFAD/EADV Eczema task force 2015 position paper on diagnosis and treatment of atopic dermatitis in adult and paediatric patients

Wollenberg

Oranje²,

Deleuran

et al. 2016

Acad Dermatol Venereol

358

488

View full text Add to dashboard Cite

show abstract

“…The atopy patch test (APT) is a patch test procedure for delayed‐type hypersensitivity reactions against protein allergens known to elicit IgE‐mediated type I sensitization in atopic patients and may reveal type IV sensitization in patients who are negative for the respective type I tests . The APT uses intact protein allergens instead of haptens in an optimized test setting and with a special reading key .…”

Section: Diagnostic Procedures and Differential Diagnosis Of Atopic Dmentioning

confidence: 99%

Atopic dermatitis and skin allergies - update and outlook

Wollenberg

Feichtner

2013

Allergy

View full text Add to dashboard Cite

During the last few years, an impressive amount of experimental studies and clinical trials have dealt with a variety of distinct topics in allergic skin diseasesespecially atopic dermatitis. In this update, we discuss selected recent data that provide relevant insights into clinical and pathophysiological aspects of allergic skin diseases or discuss promising targets and strategies for the future treatment of skin allergy. This includes aspects of barrier malfunction and inflammation as well as the interaction of the cutaneous immune system with the skin microbiome and diagnostic procedures for working up atopic dermatitis patients. Additionally, contact dermatitis, urticaria, and drug reactions are addressed in this review. This update summarizes novel evidence, highlighting current areas of uncertainties and debates that will stimulate scientific discussions and research activities in the field of atopic dermatitis and skin allergies in the future.A variety of distinct topics in allergic skin diseases and especially atopic dermatitis (AD) has been addressed in the biomedical literature published during the last few years. Recent work has focused on many clinical and pathophysiological aspects of allergic skin diseases, discussing promising targets and strategies for the future treatment of skin allergies (1, 2). In this review, we summarize novel evidence and highlight current areas of research in AD, contact dermatitis, urticaria, drug reactions, and other allergic skin diseases. Risk factors and severity scoring of atopic dermatitisAD is a common, clinically defined skin disease frequently associated with allergic rhinitis, asthma, and immunoglobulin E (IgE)-mediated food reactions (3, 4). The high variability of clinical phenotype and severity, genetic background, and known pathomechanisms strongly suggests a high degree of pathophysiological heterogeneity (5). Although the clinical pattern of eczematous skin lesion is relatively uniform, AD often shows distinct progression patterns, hence requiring personalized prevention and management strategies (5).Determinants of AD were extracted from the public-use files of the German Interview and Examination Survey for Children and Adolescents (KIGGS) study, a nationwide cross-sectional representative survey including 17 641 German children aged 0-17 years with a response rate of 66.6% (6). The weighted prevalence of ever physician-diagnosed eczema was 13.2% (95% CI 12.5-13.9%), with significant positive associations between parental allergies (OR 1.94, 95% CI 1.72-2.19), parent-reported infection after birth (OR 1.45, 95% CI 1.05-2.00), and parent-reported jaundice after birth (OR 1.27, 95% CI 1.04-1.54). Being a migrant (OR 0.63, 95% CI 0.49-0.80) and keeping a dog (OR 0.78, 95% CI 0.64-0.96) showed significant inverse associations with eczema. Other lifestyle (alcohol consumption during pregnancy) and environmental factors (mold on the walls, pets) Abbreviations AD, atopic dermatitis; CU, chronic spontaneous urticaria; DOCK8, dedicator of cytokinesis 8 ...

show abstract

“…To guarantee sensitivity, specificity, and reproducibility, only the standardized APT technique developed by the European Task Force on Atopic Dermatitis should be used. Due to limited availability, high costs of standardized test substances, and restricted reimbursement, APT is not used routinely for AFR testing …”

Section: Diagnosismentioning

confidence: 99%

Comparing immediate‐type food allergy in humans and companion animals—revealing unmet needs

Pali‐Schöll

Lucia²,

Jackson³

et al. 2017

Allergy

View full text Add to dashboard Cite

Adverse food reactions occur in human as well as veterinary patients. Systematic comparison may lead to improved recommendations for prevention and treatment in both. In this position paper, we summarize the current knowledge on immediate-type food allergy vs other food adverse reactions in companion animals, and compare this to the human situation. While the prevalence of food allergy in humans has been well studied for some allergens, this remains to be investigated for animal patients, where owner-reported as well as veterinarian-diagnosed food adverse reactions are on the increase. The characteristics of the disease in humans vs dogs, cats, and horses are most often caused by similar, but sometimes species-dependent different pathophysiological mechanisms, prompting the specific clinical symptoms, diagnoses, and treatments. Furthermore, little is known about the allergen molecules causative for type I food allergy in animals, which, like in human patients, could represent predictive biomarkers for risk evaluation. The definite diagnosis of food allergy relies-as in humans-on elimination diet and provocation tests. Besides allergen avoidance in daily practice, novel treatment options and tolerization strategies are underway. Taken together, numerous knowledge gaps were identified in veterinary food allergy, which need to be filled by systematic comparative studies.

show abstract

Patch Testing for Noncontact Dermatitis: The Atopy Patch Test for Food and Inhalants

Cited by 30 publications

References 45 publications

ETFAD/EADV Eczema task force 2015 position paper on diagnosis and treatment of atopic dermatitis in adult and paediatric patients

ETFAD/EADV Eczema task force 2015 position paper on diagnosis and treatment of atopic dermatitis in adult and paediatric patients

Atopic dermatitis and skin allergies - update and outlook

Comparing immediate‐type food allergy in humans and companion animals—revealing unmet needs

Contact Info

Product

Resources

About