Pasteurella multocida Infection in a Post-chemotherapy Neutropenic Host Following Cat Exposure

Gowda, Raghavendra; Stout, Ronald

doi:10.1053/clon.2001.0013

Cited by 10 publications

(4 citation statements)

References 6 publications

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“…In the tissue, even low -virulence strains of P. multocida may grow profusely, causing marked local necrosis and a rapidly spreading cellulitis, particularly in the immunocompromised host (Gowda and Stout 2002 ;Tattevin et al 2005 ). Whether or not P. multocida persists within the host and moves beyond local infection depends on both the bacterial strain and the host response.…”

Section: Interactions Between Bacteria and Host Defensesmentioning

confidence: 99%

Pasteurella

Boyce

Harper

and

et al. 2010

Pathogenesis of Bacterial Infections in Animals

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Section: Interactions Between Bacteria and Host Defensesmentioning

confidence: 99%

Pasteurella

Boyce

Harper

and

et al. 2010

Pathogenesis of Bacterial Infections in Animals

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“…multocida (hereafter referred to as P. multocida) is an economically important opportunistic pathogen of livestock (hemorrhagic septicemia, shipping fever, and atrophic rhinitis), poultry (fowl cholera), wildlife (avian cholera), and laboratory rabbits (snuffles) (1). As a commensal of cats and dogs, P. multocida also is a significant cause of zoonotic abscesses arising mainly from bites or scratches, but it has been increasingly associated with pulmonary disease, sepsis, and meningitis in patients with underlying medical conditions that may compromise their immune status (4,10,13,15,16,20,21,29,30,35,38,48). Although the so-called dermonecrotic toxin synthesized by some P. multocida strains produces atrophic rhinitis, the toxin is not essential for respiratory or systemic disease.…”

mentioning

confidence: 99%

Sialic Acid Metabolism and Systemic Pasteurellosis

et al. 2005

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Pasteurella multocida subsp. multocida is a commensal and opportunistic pathogen of food animals, wildlife, and pets and a zoonotic cause of human infection arising from contacts with these animals. Here, an investigation of multiple serotype A strains demonstrated the occurrence of membrane sialyltransferase. Although P. multocida lacks the genes for the two earliest steps in de novo sialic acid synthesis, adding sialic acid to the growth medium resulted in uptake, activation, and subsequent transfer of sialic acid to a membrane acceptor resembling lipooligosaccharide. Two candidate-activating enzymes with homology to Escherichia coli cytidine 5-monophospho-N-acetylneuraminate synthetase were overproduced as histidine-tagged polypeptides. The synthetase encoded by pm0187 was at least 37 times more active than the pm1710 gene product, suggesting pm0187 encodes the primary sialic acid cytidylyltransferase in P. multocida. A sialate aldolase (pm1715) mutant unable to initiate dissimilation of internalized sialic acid was not attenuated in the CD-1 mouse model of systemic pasteurellosis, indicating that the nutritional function of sialate catabolism is not required for systemic disease. In contrast, the attenuation of a sialate uptake-deficient mutant supports the essential role in pathogenesis of a sialylation mechanism that is dependent on an environmental (host) supply of sialic acid. The combined results provide the first direct evidence of sialylation by a precursor scavenging mechanism in pasteurellae and of a potential tripartite ATP-independent periplasmic sialate transporter in any species.

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“…Infections due to P. multocida in a normal population have been categorized as: 1) a local infection following an animal bite or scratch that can progress to variegated presentations such as abscess formation, tenosynovitis, septic arthritis and osteomyelitis, 2) an infection of the respiratory tract (pneumonia, empyema and lung abscess), and 3) a systemic infection, for instance, intra-abdominal infections, peritonitis, meningitis and brain abscess [2,7,8].…”

Section: Discussionmentioning

confidence: 99%

“…P. multocida causes a wide array of presentations, the most common being cutaneous, or soft tissue infections, followed by infections of the lower respiratory tract, such as pneumonia, empyema and lung abscess. Systemic infections, such as bacteremia, meningitis or peritonitis are also common presentations [2]. Immunocompromised hosts, particularly cancer patients, are more likely to develop the more severe, systemic presentations as a result of P. multocida infections [3].…”

Section: Clinical Reportmentioning

confidence: 99%

Pasteurella multocida infections in cancer patients

2010

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Background: Pasteurella multocida is a small, gram-negative coccobacillus, which most commonly causes soft tissue infections due to animal bites or scratches, mainly from cats and dogs. Immunocompromised hosts, such as cancer patients, are more likely to develop systemic complications as a result of P. multocida infections. Objective: Retrospectively analyze the medical records of four afflicted patients being managed at Moffitt Cancer Center, Tampa, USA between 1999 and 2009, and careful study for additional 32 cases of P. multocida infection among cancer patients with variegated histology found in the current medical literature. Methods: Of 36 subjects, 67% of the patients had been diagnosed with a solid organ cancer, whereas 33% had a hematologic malignancy. Clinical scenarios described fever as the most frequent initial presentation and bacteremia as the most prevalent mode of infection. Results: Forty-seven percent of the patients had experienced some sort of animal contact and 41% showed evidence of skin or soft tissue infection. The status of the white blood cell count, was available in 22 patients (of 36 patients), and 27% demonstrated neutropenia. The survival percentage of the patients with known clinical outcome was 77%. Conclusion: Medical management mostly involved antibiosis with beta-lactams. Atypical scenario of Pasteurella multocida infection may involve bites or scratches (specifically from cats or dogs) in a cancer patient presenting with sepsis and accompanied by skin or soft tissue or respiratory tract infection. A high level of suspicion for P. multocida as a possible pathogen in cancer patients would facilitate an amelioration in morbidity ameliorating, and timely initiation of specific antibiotics.

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Pasteurella multocida Infection in a Post-chemotherapy Neutropenic Host Following Cat Exposure

Cited by 10 publications

References 6 publications

Pasteurella

Pasteurella

Sialic Acid Metabolism and Systemic Pasteurellosis

Pasteurella multocida infections in cancer patients

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