Past History of Obesity (Overweight by WHO Criteria) Is Associated With an Increased Risk of Nonfatal Acute Myocardial Infarction-A Case-Control Study in JPN-

Washio, Masakazu; Hayashi, Ryoko

doi:10.1253/circj.68.41

Cited by 17 publications

(10 citation statements)

References 27 publications

(27 reference statements)

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“…[15][16][17] However, a recent casecontrol study has indicated that past obesity is a CHD risk factor, even after weight reduction. 18 In the present report, we have also shown that obesity is a CHD risk factor in young and middle-aged males, but not in females or older males. The age-and gender-related differences in the CHD risk associated with obesity might contribute, at least in part, to these conflicting data.…”

Section: Discussionsupporting

confidence: 63%

“…1,12 There have also been conflicting data regarding the relationship between obesity and CHD in Japan. [13][14][15][16][17][18] Some prospective studies have revealed that obesity is a CHD risk factor after adjusting for other risk factors, in Japan as well as in Western countries, 13,14 but other case -control studies have not found the same result. [15][16][17] However, a recent casecontrol study has indicated that past obesity is a CHD risk factor, even after weight reduction.…”

Section: Discussionmentioning

confidence: 99%

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Relation of Obesity to Acute Myocardial Infarction in Japanese Patients Differences in Gender and Age

Shiraishi

Kohno

Sawada

et al. 2006

Circ J

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besity is a risk factor for coronary heart disease (CHD) among adults 1 and is increasing in prevalence among young adults, as well as adults. 2,3 A recent report indicated a significant association of obesity with coronary atherosclerosis in young male adults, particularly in those with a central pattern of adiposity, and little association of obesity with coronary atherosclerosis in young female adults. 4 Still another recent report points out that adiposity and its metabolic disturbances (ie, metabolic syndrome) are associated with early atherosclerotic change in adolescents. 5 Recently we demonstrated that young Japanese patients with acute myocardial infarction (AMI) have a higher body mass index (BMI) compared with older patients, 6 but it remains uncertain whether obesity is a CHD Circulation Journal Vol. 70, December 2006 risk factor in young adults as well as older adults in Japan.The AMI-Kyoto Multi-Center Risk Study, a large multicenter observational study in which 16 collaborating hospitals in Kyoto Prefecture have collected demographic, procedural, and outcome data on AMI patients, was established in 2000 in order to analyze these data and establish an emergency-hospital network for heart diseases in Kyoto. 6,7 The Kyoto Citizen's Health and Nutrition Study was performed among residents in Kyoto Prefecture, in order to examine behavior and lifestyle habits and develop effective public health intervention. 8,9 In the present study we used cases from the AMI-Kyoto Multi-Center Risk Study, and controls from the Kyoto Citizen's Health and Nutrition Study, respectively, to assess obesity as a risk factor for AMI in subgroups of 20-year age bands of each gender separately, based on a multi-center case -control study. Methods Case and Control SubjectsFrom January 2000 to June 2004, 1,651 consecutive patients with a diagnosis of AMI, who were admitted to AMIKyoto Multi-Center Risk Study Group Hospitals within 1 week after the onset of AMI, were enrolled in the present Background It remains uncertain whether obesity is an independent risk factor for coronary heart disease in young adults, as well as adults, in Japan. Methods and ResultsIn the present study, 1,260 cases of acute myocardial infarction (AMI) and 3,775 community controls were recruited from the AMI-Kyoto Multi-Center Risk Study and Kyoto Citizen's Health and Nutrition Study, respectively. Obesity and other risk factors were retrospectively examined between cases and controls in each subgroup of young males (20-40 years), middle-aged males or females (40-60 years), older males or females (60-80 years), and very old males or females (80-100 years). In young, middle-aged, and older males, as well as in older females, cases had a higher body mass index (BMI) than controls. In young males, as well as in middle-aged and older females, cases had a higher prevalence of smoking than controls. Except for very old males, the prevalences of hypercholesterolemia, hypertension, and diabetes mellitus were higher in each subgroup of cases than in controls. M...

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Relation of Obesity to Acute Myocardial Infarction in Japanese Patients Differences in Gender and Age

Shiraishi

Kohno

Sawada

et al. 2006

Circ J

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“…22,23) In addition, the published cohort studies which investigated obese adults for more than 10 years suggested that past obesity, especially obesity lasting over 10 years, might cause an approximately 2-fold increase in the risk of CHD. 24) Our data show that obesity is the most important independent metabolic risk factor for a CHD event in the younger Japanese subjects. Thus, intensive community-based intervention for primary prevention of obesity should be carried out, especially in childhood.…”

Section: Discussionmentioning

confidence: 54%

Characteristics of Metabolic and Lifestyle Risk Factors in Young Japanese Patients With Coronary Heart Disease A Comparison With Older Patients

et al. 2006

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SUMMARYCoronary heart disease (CHD) is recognized as a lifestyle-related disease and is the second leading cause of death in Japan. However, the cardiac risk factor profile of young patients with CHD has not been clarified in suburban areas of Japan. Our study aimed to determine metabolic and lifestyle risk factors in young patients and compare them with older patients living in suburban areas of Nagano Prefecture.A multicenter study was conducted in 86 young (aged less than 40 years) and 91 older (aged 50 years and over) patients diagnosed with CHD from 1992 to 2002. There was a strong association between obesity and the occurrence of CHD events in young patients (odds ratio = 3.61, P = 0.006). Lifestyle in the young patients was characterized by a lack of physical activity and regular physical activity was found to decrease the risk of the CHD events in these patients (odds ratio = 0.31, P = 0.030). In older patients, hypertension was identified as an independent risk factor for CHD events.The results of the present study have demonstrated that obesity and a lack of regular physical exercise are independent risk factors for CHD events in younger patients. Thus, the data may be useful for the effective screening of high-risk individuals and the development of educational programs for the prevention of CHD, especially in younger Japanese. (Int Heart J 2006; 47: 343-350)

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“…There have been conflicting data regarding the relationship between obesity and coronary heart disease (CHD) in Japanese (1)(2)(3)(4)(5)(6)(7). Some prospective studies have revealed that obesity is a CHD risk factor after adjusting for other risk factors in Japan as well as in Western countries (1,2), but other case-control studies have not found the same result (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Age- and Gender-related Differences in Correlations between Abdominal Obesity and Obesity-related Metabolic Risk Factors in Japanese

Oda

Kawai

2009

Intern. Med.

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Past History of Obesity (Overweight by WHO Criteria) Is Associated With an Increased Risk of Nonfatal Acute Myocardial Infarction-A Case-Control Study in JPN-

Cited by 17 publications

References 27 publications

Relation of Obesity to Acute Myocardial Infarction in Japanese Patients Differences in Gender and Age

Relation of Obesity to Acute Myocardial Infarction in Japanese Patients Differences in Gender and Age

Characteristics of Metabolic and Lifestyle Risk Factors in Young Japanese Patients With Coronary Heart Disease A Comparison With Older Patients

Age- and Gender-related Differences in Correlations between Abdominal Obesity and Obesity-related Metabolic Risk Factors in Japanese

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