Passive transfer of experimental hypersensitivity pneumonitis with lymphoid cells in the rabbit

Bice, David E.; Salvaggio, John E.; Hoffman, E.

doi:10.1016/0091-6749(76)90130-5

Cited by 30 publications

(13 citation statements)

References 17 publications

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“…Further, the production of macro phage migration inhibition factor (MIF), which is regarded by some investigators [3,8] as an in vitro correlate of type IV hyper sensitivity, has been shown to be produced by bronchoalveolar lymphocytes of rabbits immunized with M. faeni, as well as by peri pheral blood lymphocytes of patients with hypersensitivity pneumonitis [11,15]. Ex perimental results also indicate that hyper sensitivity responsible for the production of lesions after lung challenge with antigen is passively transferred with sensitized lymph oid cells but not with serum [2],…”

Section: Introductionsupporting

confidence: 57%

Adjuvant Properties of Micropolyspora faeni

Bice

Hoffman

et al. 1977

Int Arch Allergy Immunol

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The adjuvant properties of Micropolyspora faeni, an important source of antigenic material in the production of farmer’s lung, were evaluated by comparing antibody- and cell-mediated immune responses of rabbits to bovine serum albumin (BSA) incorporated in complete Freund’s adjuvant (CFA), incomplete Freund’s adjuvant (IFA) and incomplete Freund’s adjuvant with 5–10 mg/ml homogenized M. faeni (MFA). Rabbits immunized with BSA in CFA or MFA developed significantly increased antigen-induced macrophage migration inhibition, lymphocyte stimulation, and delayed skin reactivity when compared to those immunized with BSA in IFA. No similar adjuvant effect on specific antibody production was observed in rabbits immunized using BSA in MFA. These data suggest that M. faeni can act as a selective immunologic adjuvant for delayed hypersensitivity. This adjuvant property might be important in the induction of mononuclear cell infiltrates seen in human hypersensitivity pneumonitis.

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Section: Introductionsupporting

confidence: 57%

Adjuvant Properties of Micropolyspora faeni

Bice

Hoffman

et al. 1977

Int Arch Allergy Immunol

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“…The immunological sensitivity re sponsible for some antigen reactions in the lung has also been passively transferred to unimmunized animals by immune lympho-cytes [7,16,17]. Although the data in these publications imply that cellular immunity is an active process in the lung, little informa tion is available that identifies the tissues in volved in producing antigen-sensitive T lymphocytes following lung immunization and the routes taken by these cells to return to the lung.…”

Section: Discussionmentioning

confidence: 97%

“…Cellular immunity occurs in the lung in both lung defense [1][2][3][4] and in disease proc esses [5][6][7], Most studies have examined the ability of sensitized lymphocytes obtained from the lower respiratory tract by bronchoalveolar lavage to produce macrophage inhibition factor (MIF) and inhibit the mi gration of pulmonary alveolar macrophages. Although one study suggested that pulmon ary alveolar macrophages lack MIF recep tors [8], other studies have found that these cells do respond to MIF produced by lung or lymph node lymphocytes [1-5, 9J.…”

Section: Introductionmentioning

confidence: 99%

Cellular Immunity Induced by Lung Immunization of Fischer 344 Rats

Bice¹,

Schnizlein²

1980

Int Arch Allergy Immunol

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This study describes immunologic responses in lung-associated lymph nodes, spleen, cervical lymph nodes and lung lavage cells of rats immunized by intratracheal instillation of BCG-sheep red blood cell (SRBC) suspensions. At 4 through 17 days after immunization, the number of anti-SRBC IgM and IgG antibody-forming cells was significantly increased only in the lung-associated lymph nodes, indicating that these tissues retain the particulate antigen that was deposited in the lung. In contrast, cellular immunity was found initially in the spleen, with significant responses in the lungs and in the lung-associated lymph nodes only 13–19 days after immunization. Our data indicated that the lung-associated lymph nodes are probably the initial site for the production of antigen-sensitive lymphocytes for both antibody and cellular immunity after lung immunization. Cells responsible for cellular immunity appear to migrate to the spleen, where further cell division takes place.

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“…In an attempt to demonstrate a role for either circulating antibody or delayed hypersensitivity in the production of experimental pneumonitis, hyperimmune serum and specifically sensitized lymphoid cells from animals previously immunized with ovalbumin were transferred to normal rabbits followed by ovalbumin aerosol or intratracheal challenge in our laboratory (43). Rabbits passively sensitized with hyperimmune serum demonstrated only mild and inconsistent peribronchial mononuclear cell infiltrates following aerosol challenge.…”

Section: Animal Modelsmentioning

confidence: 99%