“…Previous reports [4,5] indicated that strain 2 guinea pigs do not develop RTD and that they differ significantly in their im mune and inflammatory responses from strain 13 [3,4,6], Hartley [4,6,14,17], C4-deficicnt [8], NIH multipurpose [8], and Albany [14] guinea pigs. Three major dif ferences were alleged: active immunization of strain 2 with TBM was ineffective in in ducing autoantibodies unless large amounts of antigen were injected [4|.…”