Passive stretch relationships in human uterine muscle

Conrad, John T.; Johnson, Wayne L.; Kühn, W.; Hunter, Charles A.

doi:10.1016/0002-9378(66)90513-8

Cited by 25 publications

(19 citation statements)

References 6 publications

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“…The content of muscle fibers increases during pregnancy and decreases with menopause [21]. [22][23][24][25], uniaxial compression [23], aspiration [26], and biaxial tension [27]. In one of the first studies to ever measure the material properties of the uterus, Conrad et al [22] determined the passive stress relaxation of the uterus from pregnant and nonpregnant patients.…”

Section: Uterusmentioning

confidence: 99%

“…[22][23][24][25], uniaxial compression [23], aspiration [26], and biaxial tension [27]. In one of the first studies to ever measure the material properties of the uterus, Conrad et al [22] determined the passive stress relaxation of the uterus from pregnant and nonpregnant patients. The study found that uterine tissue from pregnant patients experienced a rate of stress relation that was higher than uterine tissue from nonpregnant patients under the same strain levels.…”

Section: Uterusmentioning

confidence: 99%

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Mechanical Properties of Female Reproductive Organs and Supporting Connective Tissues: A Review of the Current State of Knowledge

Baah-Dwomoh

McGuire

Tan

et al. 2016

Applied Mechanics Reviews

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Although there has been an upsurge of interest in research on women's sexual and reproductive health, most of the research has remained confined to the obstetrics and gynecology disciplines, without knowledge flow to the biomechanics community. Thus, the mechanics of the female reproductive system and the changes determined by pregnancy, age, obesity, and various medical conditions have not been thoroughly studied. In recent years, more investigators have been focusing their efforts on evaluating the mechanical properties of the reproductive organs and supportive connective tissues, but, despite the many advances, there is still a lot that remains to be done. This paper provides an overview of the research published over the past few decades on the mechanical characterization of the primary female reproductive organs and supporting connective tissues. For each organ and tissue, after a brief description of the function and structure, the testing methods and main mechanical results are presented. Constitutive equations are then reviewed for all organs/tissues together. The goal is to spark the interest of new investigators to this largely untapped but fast-evolving branch of soft tissue mechanics that will impact women's gynecologic, reproductive, and sexual health care.

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Section: Uterusmentioning

confidence: 99%

Section: Uterusmentioning

confidence: 99%

Mechanical Properties of Female Reproductive Organs and Supporting Connective Tissues: A Review of the Current State of Knowledge

Baah-Dwomoh

McGuire

Tan

et al. 2016

Applied Mechanics Reviews

View full text Add to dashboard Cite

show abstract

“…4(a) illustrate the nonlinear elastic behavior of the uterine tissue, along with differences between pregnant and nonpregnant tissue tested in tension [69]. Figure 4(b) highlights the anisotropy and viscoelasticity.…”

Section: Mechanical Testing and Properties Of Uterinementioning

confidence: 99%

“…4 Representative data from the literature showing the complex mechanical behavior of uterine tissue. (a) The nonlinear elastic behavior in the stress-elongation data and differences for pregnant versus non pregnant tissue [69]. Nonpregnant uterine tissue is stiffer than pregnant tissue for the entire range of stress and elongation shown.…”

Section: Mechanical Testing and Properties Of Cervicalmentioning

confidence: 99%

“…There are no data available on animal uterine tissue, to the best of our knowledge. Uterine tissue has been tested in tension [66,69,70] and in static and dynamic compression [66,71] using either traditional mechanical testing system or ultrasound methods [72], as summarized in Table 2. While mechanical testing of uterine tissue in tension may yield the most physiologically [72] relevant data, these tests are difficult to conduct because of challenges associated with mounting tissue samples.…”

Section: Mechanical Testing and Properties Of Uterinementioning

confidence: 99%

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System-Level Biomechanical Approach for the Evaluation of Term and Preterm Pregnancy Maintenance

Mahmoud

Johnson

Chien

et al. 2013

Journal of Biomechanical Engineering

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Preterm birth is the primary contributor to perinatal morbidity and mortality, with those born prior to 32 weeks disproportionately contributing compared to those born at 32-37 weeks. Outcomes for babies born prematurely can be devastating. Parturition is recognized as a mechanical process that involves the two processes that are required to initiate labor: rhythmic myometrial contractions and cervical remodeling with subsequent dilation. Studies of parturition tend to separate these two processes rather than evaluate them as a unified system. The mechanical property characterization of the cervix has been primarily performed on isolated cervical tissue, with an implied understanding of the contribution from the uterine corpus. Few studies have evaluated the function of the uterine corpus in the absence of myometrial contractions or in relationship to retaining the fetus. Therefore, the cervical-uterine interaction has largely been neglected in the literature. We suggest that a system-level biomechanical approach is needed to understand pregnancy maintenance. To that end, this paper has two main goals. One goal is to highlight the gaps in current knowledge that need to be addressed in order to develop any comprehensive and clinically relevant models of the system. The second goal is to illustrate the utility of finite element models in understanding pregnancy maintenance of the cervical-uterine system. The paper targets an audience that includes the reproductive biologist/clinician and the engineer/physical scientist interested in biomechanics and the system level behavior of tissues.

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Biomechanics of the human uterus

Myers

Elad

2017

WIREs Mechanisms of Disease

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The appropriate biomechanical function of the uterus is required for the execution of human reproduction. These functions range from aiding the transport of the embryo to the implantation site, to remodeling its tissue walls to host the placenta, to protecting the fetus during gestation, to contracting forcefully for a safe parturition and postpartum, to remodeling back to its nonpregnant condition to renew the cycle of menstruation. To serve these remarkably diverse functions, the uterus is optimally geared with evolving and contractile muscle and tissue layers that are cued by chemical, hormonal, electrical, and mechanical signals. The relationship between these highly active biological signaling mechanisms and uterine biomechanical function is not completely understood for normal reproductive processes and pathological conditions such as adenomyosis, endometriosis, infertility and preterm labor. Animal studies have illuminated the rich structural function of the uterus, particularly in pregnancy. In humans, medical imaging techniques in ultrasound and magnetic resonance have been combined with computational engineering techniques to characterize the uterus in vivo, and advanced experimental techniques have explored uterine function using ex vivo tissue samples. The collective evidence presented in this review gives an overall perspective on uterine biomechanics related to both its nonpregnant and pregnant function, highlighting open research topics in the field. Additionally, uterine disease and infertility are discussed in the context of tissue injury and repair processes and the role of computational modeling in uncovering etiologies of disease. WIREs Syst Biol Med 2017, 9:e1388. doi: 10.1002/wsbm.1388 For further resources related to this article, please visit the WIREs website.

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Passive stretch relationships in human uterine muscle

Cited by 25 publications

References 6 publications

Mechanical Properties of Female Reproductive Organs and Supporting Connective Tissues: A Review of the Current State of Knowledge

Mechanical Properties of Female Reproductive Organs and Supporting Connective Tissues: A Review of the Current State of Knowledge

System-Level Biomechanical Approach for the Evaluation of Term and Preterm Pregnancy Maintenance

Biomechanics of the human uterus

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