“…Similarly, sedentary older adults have been found to have reduced PLM-induced LBF responses compared to physically active older adults ( Groot, Rossman et al, 2016 ). PLM has also provided insight into the effects of numerous disease states on central hemodynamics and peripheral microvascular function including heart failure, heart transplantation, peripheral artery disease, chronic obstructive pulmonary disease, chronic kidney disease, systemic sclerosis, spinal cord injury, and sepsis ( Hayman, Nativi et al, 2010 ; Mortensen, Askew et al, 2012 ; Venturelli, Amann et al, 2014 ; Witman, Ives et al, 2015 ; Nelson, Rossman et al, 2016 ; Clifton, Machin et al, 2018 ; Katulka, Hirt et al, 2019 ; Ives, Layec et al, 2020 ). As expected, in each of these studies we see that disease has a negative impact on at least one component of the PLM response (central or peripheral) as compared to healthy controls.…”