Passive Exercise Using Whole-Body Periodic Acceleration Enhances Blood Supply to Ischemic Hindlimb

Rokutanda, Taku; Izumiya, Yasuhiro; Miura, Mitsutoshi; Fukuda, Shota; Shimada, Kenei; Izumi, Yasukatsu; Nakamura, Yasuhiro; Araki, Satoshi; Hanatani, Shinsuke; Matsubara, Junichi; Nakamura, Taishi; Kataoka, Kazunori; Yasuda, Osamu; Kaikita, Koichi; Sugiyama, Seigo; Kim‐Mitsuyama, Shokei; Yoshikawa, Junichi; Fujita, Masatoshi; Yoshiyama, Minoru; Ogawa, Hisao

doi:10.1161/atvbaha.111.229773

Cited by 29 publications

(28 citation statements)

References 46 publications

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“…Recent WBV findings in a mouse model of hind-limb ischemia support our findings of increases in peripheral blood flow in the vascular tissue through vasodilation, stimulated by the endothelial nitric oxide synthase mechanism. 28 Yet these researchers did not examine mice without hind-limb ischemia, and the mechanism by which nitric oxide creates vasodilation may be altered. Further, examination of the exercise-hyperemia literature suggested that a large number of potential vasodilatory agents, including potassium, 29 adenosine, 30 and nitric oxide, 31 may be released with muscle contractions.…”

Section: Discussionmentioning

confidence: 99%

Whole-Body Vibration and Blood Flow and Muscle Oxygenation: A Meta-Analysis

Games

Sefton²,

Wilson

2015

Journal of Athletic Training

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Context:The use and popularity of whole-body vibration (WBV) has increased in recent years, but there is a lack of consensus in the literature about the effectiveness of the treatment.Objective: To quantitatively examine the effects of WBV on muscle oxygenation and peripheral blood flow in healthy adults.Data Sources: We searched Web of Science and PubMed databases and reference lists from relevant articles using the key terms whole body vibration, whole-body vibration, WBV, blood flow, peripheral blood flow, oxygenation, muscle oxygenation, circulation, circulatory, near infrared spectroscopy, NIRS, and power Doppler. Key terms were searched using single word and combination searches. No date range was specified.Study Selection: Criteria for inclusion were (1) use of a commercially available WBV device, (2) a human research model, (3) a pre-WBV condition and at least 1 WBV experimental condition, and (4) reporting of unstandardized means and standard deviations of muscle oxygenation or peripheral blood flow.Data Extraction: Means, standard deviations, and sample sizes were extracted from the text, tables, and figures of included studies. A total of 35 and 90 data points were extracted for the muscle-oxygenation and blood-flow meta-analyses, respectively. Data for each meta-analysis were combined and analyzed using meta-analysis software. Weighted, randomeffects meta-analyses using the Hedges g metric were completed for muscle oxygenation and blood flow. We then conducted follow-up analyses using the moderator variables of vibration type, vibration time, vibration frequency, measurement location, and sample type.Data Synthesis: We found 18 potential articles. Further examination yielded 10 studies meeting the inclusion criteria. Whole-body vibration was shown to positively influence peripheral blood flow. Additionally, the moderators of vibration type and frequency altered the influence of WBV on blood flow. Overall, WBV did not alter muscle oxygenation; however, when the measurement site was considered, muscle oxygenation increased or decreased depending on the location.Conclusions: Acute bouts of WBV increase peripheral blood flow but do not alter skeletal muscle oxygenation. Vibration type appears to be the most important factor influencing both muscle oxygenation and peripheral blood flow. Key Words: interventions, modalities, circulatory system Key PointsAn acute bout of therapeutic whole-body vibration (WBV) increases peripheral blood flow but does not alter muscleoxygenation levels. Vibration type and frequency affect peripheral blood flow and muscle oxygenation during an acute bout of WBV. Additional work examining the effects of WBV on circulatory measures in injured populations is needed. Although WBV is promising when used in healthy people, clinicians should be cautious in applying WBV as a therapeutic modality to improve vascular measures after injury or illness.O ver the past decade, the incorporation of wholebody vibration (WBV) into fitness and injury treatment programs has expanded rapidly.1,2 R...

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Section: Discussionmentioning

confidence: 99%

Whole-Body Vibration and Blood Flow and Muscle Oxygenation: A Meta-Analysis

Games

Sefton²,

Wilson

2015

Journal of Athletic Training

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“…The myocardial infarction (MI) and hind-limb ischemia (HI) models were generated as described previously. 17,18 Briefly, the trachea was cannulated with a polyethylene tube connected to a respirator (tidal volume, 0.6 mL; frequency, 110 breaths per minute). A left thoracotomy was performed between the fourth and fifth ribs.…”

Section: Wt and Sirt7mentioning

confidence: 99%

Sirt7 Contributes to Myocardial Tissue Repair by Maintaining Transforming Growth Factor-β Signaling Pathway

et al. 2015

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Background— Sirt7, 1 of the 7 members of the mammalian sirtuin family, promotes oncogenic transformation. Tumor growth and metastasis require fibrotic and angiogenic responses. Here, we investigated the role of Sirt7 in cardiovascular tissue repair process. Methods and Results— In wild-type mice, Sirt7 expression increased in response to acute cardiovascular injury, including myocardial infarction and hind-limb ischemia, particularly at the active wound healing site. Compared with wild-type mice, homozygous Sirt7-deficient (Sirt7 −/− ) mice showed susceptibility to cardiac rupture after myocardial infarction, delayed blood flow recovery after hind-limb ischemia, and impaired wound healing after skin injury. Histological analysis showed reduced fibrosis, fibroblast differentiation, and inflammatory cell infiltration in the border zone of infarction in Sirt7 −/− mice. In vitro, Sirt7 −/− mouse–derived or Sirt7 siRNA–treated cardiac fibroblasts showed reduced transforming growth factor-β signal activation and low expression levels of fibrosis-related genes compared with wild-type mice–derived or control siRNA–treated cells. These changes were accompanied by reduction in transforming growth factor receptor I protein. Loss of Sirt7 activated autophagy in cardiac fibroblasts. Transforming growth factor-β receptor I downregulation induced by loss of Sirt7 was blocked by autophagy inhibitor, and interaction of Sirt7 with protein interacting with protein kinase-Cα was involved in this process. Conclusion— Sirt7 maintains transforming growth factor receptor I by modulating autophagy and is involved in the tissue repair process.

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“…Beneficial effects of pGz in skeletal muscle have been associated with eNOS activation [36]. Therefore, here we studied the effect of pGz treatment in the time course of eNOS activation in dystrophic myotubes, measured by phosphorylation at Ser632.…”

Section: Resultsmentioning

confidence: 99%

Whole Body Periodic Acceleration Is an Effective Therapy to Ameliorate Muscular Dystrophy in mdx Mice

et al. 2014

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Duchenne muscular dystrophy (DMD) is a genetic disorder caused by the absence of dystrophin in both skeletal and cardiac muscles. This leads to severe muscle degeneration, and dilated cardiomyopathy that produces patient death, which in most cases occurs before the end of the second decade. Several lines of evidence have shown that modulators of nitric oxide (NO) pathway can improve skeletal muscle and cardiac function in the mdx mouse, a mouse model for DMD. Whole body periodic acceleration (pGz) is produced by applying sinusoidal motion to supine humans and in standing conscious rodents in a headward-footward direction using a motion platform. It adds small pulses as a function of movement frequency to the circulation thereby increasing pulsatile shear stress to the vascular endothelium, which in turn increases production of NO. In this study, we examined the potential therapeutic properties of pGz for the treatment of skeletal muscle pathology observed in the mdx mouse. We found that pGz (480 cpm, 8 days, 1 hr per day) decreased intracellular Ca2+ and Na+ overload, diminished serum levels of creatine kinase (CK) and reduced intracellular accumulation of Evans Blue. Furthermore, pGz increased muscle force generation and expression of both utrophin and the carboxy-terminal PDZ ligand of nNOS (CAPON). Likewise, pGz (120 cpm, 12 h) applied in vitro to skeletal muscle myotubes reduced Ca2+ and Na+ overload, diminished abnormal sarcolemmal Ca2+ entry and increased phosphorylation of endothelial NOS. Overall, this study provides new insights into the potential therapeutic efficacy of pGz as a non-invasive and non-pharmacological approach for the treatment of DMD patients through activation of the NO pathway.

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Passive Exercise Using Whole-Body Periodic Acceleration Enhances Blood Supply to Ischemic Hindlimb

Cited by 29 publications

References 46 publications

Whole-Body Vibration and Blood Flow and Muscle Oxygenation: A Meta-Analysis

Whole-Body Vibration and Blood Flow and Muscle Oxygenation: A Meta-Analysis

Sirt7 Contributes to Myocardial Tissue Repair by Maintaining Transforming Growth Factor-β Signaling Pathway

Whole Body Periodic Acceleration Is an Effective Therapy to Ameliorate Muscular Dystrophy in mdx Mice

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