Passive and active targeting strategies in hybrid layered double hydroxides nanoparticles for tumor bioimaging and therapy

Andrade, Karina Nava; Pérez, Ana María Puebla; Arízaga, Gregório Guadalupe Carbajal

doi:10.1016/j.clay.2019.105214

Cited by 29 publications

(31 citation statements)

References 86 publications

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“…For instance, stabilizing [28] or activating [29,30] anions are introduced to the LDH structure. LDH are promising materials to be used as nanocontainers for special anions, such as drugs [31,32], inhibitors [24], anionic dyes [33], sensor anions [34], etc.…”

Section: Literature Review and Problem Statementmentioning

confidence: 99%

“Smart” anticorrosion pigment based on layered double hydroxide: construction and characterization

Кovalenko

Kotok

2019

EEJET

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Лакофарбовi покриття широко використовуються в свiтi як для надання декоративних властивостей, так i для захисту металевих виробiв вiд корозiї. Однак звичайнi лакофарбовi покриття мають тiльки пасивним типом захисту металу. Для створення активного типу протикорозiйного захисту у лакофарбовi покриття вводять окремi антикорозiйнi добавки. В результатi аналiзу даних в якостi бi-функцiонального (одночасно кольорового i протикорозiйного) пiгмента теоретично був сконструйований монофазний Zn-Al-триполiфосфатний ПШГ загальної формули Zn 0.8 Al 0.2 (P 3 O 10 ) 0.04 . В даному СДГ Zn 2+ я катiон-«хазяїн» i Al 3+ як катiон-«гiсть» вiдповiдають за бiлий колiр пiгменту, а iнтеркальвоний триполiфосфат-анiон -iнгiбитор корозiї. В якостi методу отримання був обраний безперервний синтез при рiвноважному рН при температурi 70 °С. Даним методом отримано зразок сконструйованого теоретично пiгменту. Кристалiчна структура зразку вивчена методом рентгенофазового аналiзу, морфологiя i розмiр часток методом скануючої електронної мiкроскопiї, термiчнi властивостi методом термогравiметрiї. Характеристики кольору були отриманi за допомогою компаратору кольору, протикорозiйнi властивостi вивченi електрохiмiчно методом зняття анодних поляризацiйних кривих сталi 08Кп в 5 % (масс.) розчинi Na 2 SO 4 з екстрактом пiгменту та без екстракту. Методом рентгенофазового аналiзу встановлено формування бi-фазного продукту, що складається iз сконструйованого ПШГ (iз структурою Zn(OH) 2 ) та Zn-Al ПШО (iз структурою ZnO). Це вказує на частковий розпад ПШГ в момент отримання, причина розпаду не виявлена. Методом СЕМ показано формування однакових часток, якi є агломератами бiльш мiлких часток, та мають високорозвинену поверхню. Вивчення характеристик кольору виявило, що отриманий пiгмент має високу ступiнь бiлого (коефiцiент дифузного вiдбиття бiльше 90 %, чистота кольору менше 1 %, свiтлота бiльше 96 %). Це обумовлено кольором як ПШГ-фази, так i ПШО-фази. Методом зняття анодних поляризацiйних кривих показано зниження швидкостi корозiї сталi в присутностi водного екстракту пiгмента в 5,36 рази (густина струму корозiї знижується з 5.63 мА/см 2 до 1.03 мА/см 2 ). Все це чiтко доводить, что синтезовано бi-функцiональний «розумний» пiгмент, що має високi пiгментнi властивостi, високу ступiнь бiлого та високi корозiйно-захиснi властивостiКлючовi слова: лакофарбовi покриття, Zn-Al ПШГ, «розумний» бi-функцiональний пiгмент, триполiфосфат, iнгiбiтор UDC 54.057:544.653:621.13:661.13

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Section: Literature Review and Problem Statementmentioning

confidence: 99%

“Smart” anticorrosion pigment based on layered double hydroxide: construction and characterization

Кovalenko

Kotok

2019

EEJET

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“…Furthermore, in vivo studies revealed that TZB decorated liposome-PEG-PEI complex (LPPC) improved the site specific delivery of docetaxel-loaded LPPC to the tumor area but not to the healthy organs 17 . In addition, designing the NPs in the size range of 100-200 nm while applying a camouflaged surface coating, passive accumulation of these nanocarriers, resulting from their long circulation and enhanced permeation and retention, will synergize their active targeting 18 .…”

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confidence: 99%

Near IR responsive targeted integrated lipid polymer nanoconstruct for enhanced magnolol cytotoxicity in breast cancer

Elhabak

Osman

Mohamed

et al. 2020

Sci Rep

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Advances in cancer nanotechnology aim at improving specificity and effectiveness for tumor treatment. Amalgamation of different treatment modalities is expected to provide better cancer combating. Herein, We developed a long circulating nanocarrier comprising trastuzumab (TZB) surface modified polylactic-co-glycolic acid (pLGA) nanoparticles (nps) co-encapsulating magnolol (Mag) and gold nanoparticles (GNPs). A modified single step nanoprecipitation method was adopted ensuring particle coating with D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) while co-encapsulating Gnps. tZB was then anchored on nps surface using a carbodiimide chemistry. the cytotoxicity of the developed system was evaluated with and without photothermal irradiation. nps cellular uptake was then followed using confocal microscopical imaging. A hybrid matrix composed of pLGA/tpGS and surface decorated with TZB with a conjugation efficiency of ˃65%, was confirmed via ftiR, 1 HnMR. Gnps could only be included in the nps, when placed in the organic phase as evidenced by the shifted GNPs surface plasmonic resonance and confirmed via imaging coupled with energy dispersive X-ray analysis. Optimized NPs (136.1 ± 1.3 nm, −8.2 ± 1 mV and Mag encapsulation efficiency of 81.4 ± 1.8%) were able to boost Mag cytotoxicity on breast cancer cells while providing a selective multifunctional therapy with an added photothermal effect. Despite the great advances in cancer research, breast cancer remains one of the most challenging diseases risking the lives of a considerable proportion of women world wide 1. Lack of selectivity, poor drug penetration in solid tumors, multi drug resistance (MDR) with increased cells sensitivity added to the drug systemic side effects, represent some of the major barriers for a successful therapy 2. Smart drug delivery systems incorporating different cancer targeting approaches including: passive, active and stimuli responsive had been suggested to improve outcomes of cancer treatment 3,4. In this study, we focused on integrating many strategies that could potentiate the effect of a natural cytotoxic drug with potential activity against breast cancer. Magnolol (Mag), see structure Fig. S1, is a phenolic polyhydroxy compound isolated from the root and stem bark of Magnolia Officinalis 5. It had been found to inhibit proliferation and induce apoptosis in MCF-7 breast cancer cells via the intrinsic pathway with release of apoptosis inducing factor from mitochondria 5,6. Studies have also shown that Mag inhibited cell growth and HER2-mediated tumor metastasis in human HER2-cancer cells 7. Although, Mag might be considered a potential lead drug in breast cancer treatment yet, its delivery is usually hampered by poor aqueous solubility and low oral bioavailability 6,8. Hence, its incorporation in a smart nanocarrier is expected to improve its delivery characteristics and boost its anticancer properties especially with the incorporation of multifunctional adjuvants.

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“…Besides, passive targeting can promote MDR apparition due to its lack of control and the consequent undue drug accumulation in cancer cells, a fact which, on the contrary, can be overcome by active targeting [17]. This second delivery process accomplishes a specific recognition of tumor cells that favors controlled DDS internalization in them, increasing their therapeutic efficiency [19]. Such targeting can be attained by chemical changes in the NP and liposome surface, making it more reactive to the tumor microenvironment, or with ligands that specifically recognize overexpressed receptors or proteins in cancer cells, such as several peptides, aptamers, and antibodies [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

“…This second delivery process accomplishes a specific recognition of tumor cells that favors controlled DDS internalization in them, increasing their therapeutic efficiency [19]. Such targeting can be attained by chemical changes in the NP and liposome surface, making it more reactive to the tumor microenvironment, or with ligands that specifically recognize overexpressed receptors or proteins in cancer cells, such as several peptides, aptamers, and antibodies [17][18][19][20]. Among these three targeting molecules, peptides and aptamers are smaller, less immunogenic, more easily chemically modifiable, and more temperature-stable than antibodies.…”

Section: Introductionmentioning

confidence: 99%

Trastuzumab: More than a Guide in HER2-Positive Cancer Nanomedicine

2020

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HER2 overexpression, which occurs in a fifth of diagnosed breast cancers as well as in other types of solid tumors, has been traditionally linked to greater aggressiveness. Nevertheless, the clinical introduction of trastuzumab has helped to improve HER2-positive patients’ outcomes. As a consequence, nanotechnology has taken advantage of the beneficial effects of the administration of this antibody and has employed it to develop HER2-targeting nanomedicines with promising therapeutic activity and limited toxicity. In this review, the molecular pathways that could be responsible for trastuzumab antitumor activity will be briefly summarized. In addition, since the conjugation strategies that are followed to develop targeting nanomedicines are essential to maintaining their efficacy and tolerability, the ones most employed to decorate drug-loaded nanoparticles and liposomes with trastuzumab will be discussed here. Thus, the advantages and disadvantages of performing this trastuzumab conjugation through adsorption or covalent bindings (through carbodiimide, maleimide, and click-chemistry) will be described, and several examples of targeting nanovehicles developed following these strategies will be commented on. Moreover, conjugation methods employed to synthesized trastuzumab-based antibody drug conjugates (ADCs), among which T-DM1 is well known, will be also examined. Finally, although trastuzumab-decorated nanoparticles and liposomes and trastuzumab-based ADCs have proven to have better selectivity and efficacy than loaded drugs, trastuzumab administration is sometimes related to side toxicities and the apparition of resistances. For this reason also, this review focuses at last on the important role that newer antibodies and peptides are acquiring these days in the development of HER2-targeting nanomedicines.

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Passive and active targeting strategies in hybrid layered double hydroxides nanoparticles for tumor bioimaging and therapy

Cited by 29 publications

References 86 publications

“Smart” anticorrosion pigment based on layered double hydroxide: construction and characterization

“Smart” anticorrosion pigment based on layered double hydroxide: construction and characterization

Near IR responsive targeted integrated lipid polymer nanoconstruct for enhanced magnolol cytotoxicity in breast cancer

Trastuzumab: More than a Guide in HER2-Positive Cancer Nanomedicine

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Passive and active targeting strategies in hybrid layered double hydroxides nanoparticles for tumor bioimaging and therapy

Cited by 29 publications

References 86 publications

“Smart” anti­corrosion pigment based on layered double hydroxide: construction and characterization

“Smart” anti­corrosion pigment based on layered double hydroxide: construction and characterization

Near IR responsive targeted integrated lipid polymer nanoconstruct for enhanced magnolol cytotoxicity in breast cancer

Trastuzumab: More than a Guide in HER2-Positive Cancer Nanomedicine

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“Smart” anticorrosion pigment based on layered double hydroxide: construction and characterization

“Smart” anticorrosion pigment based on layered double hydroxide: construction and characterization