Passion fruit-like exosome-PMA/Au-BSA@Ce6 nanovehicles for real-time fluorescence imaging and enhanced targeted photodynamic therapy with deep penetration and superior retention behavior in tumor

Pan, Shaojun; Pei, Lijia; Zhang, Amin; Zhang, Yuhui; Zhang, Chunlei; Huang, Mengling; Huang, Zhicheng; Liu, Bin; Wang, Lirui; Ma, Lijun; Zhang, Qian; Cui, Daxiang

doi:10.1016/j.biomaterials.2019.119606

Cited by 113 publications

(101 citation statements)

References 37 publications

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“…Proper modification of EVs can increase their delivery efficiency, targeting ability, and therapeutic efficacy. [48,49] EVs from different sources, including tumor cells, [50] stem cells, [51,52] immune cells, [39,53] human blood and urine, [54,55] and milk, [56] have been tested for this purpose. Strategies and methodologies that are commonly used for EV engineering have been well documented in previous reviews and are briefly summarized here.…”

Section: Strategies Of Ev Engineeringmentioning

confidence: 99%

“…In response to laser irradiation and acidic condition, the engineered nanovehicles are broken and tremendous NPs are released inside, producing considerable singlet oxygen and thus inhibiting tumor cell growth. [55] To achieve comprehensive therapy, Wang et al have preloaded Bi 2 Se 3 nanodots and DOX into tumor cells via electroporation and obtained MPs (Bi 2 Se 3 /DOX@MPs) through irradiation-induced budding. Bi 2 Se 3 /DOX@MPs show synergistic antitumor efficacy by combining PTT with low-dose chemotherapy.…”

Section: Engineered Evs As Delivery Systems For Cancer-targeted Photothermal Therapymentioning

confidence: 99%

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Engineered Extracellular Vesicles for Cancer Therapy

et al. 2021

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Extracellular vesicles (EVs) have emerged as a novel cell‐free strategy for the treatment of many diseases including cancer. As a result of their natural properties to mediate cell‐to‐cell communication and their high physiochemical stability and biocompatibility, EVs are considered as excellent delivery vehicles for a variety of therapeutic agents such as nucleic acids and proteins, drugs, and nanomaterials. Increasing studies have shown that EVs can be modified, engineered, or designed to improve their efficiency, specificity, and safety for cancer therapy. Herein, a comprehensive overview of the recent advances in the strategies and methodologies of engineering EVs for scalable production and improved cargo‐loading and tumor‐targeting is provided. Additionally, the potential applications of engineered EVs in cancer therapy are discussed by presenting prominent examples, and the opportunities and challenges for translating engineered EVs into clinical practice are evaluated.

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Section: Strategies Of Ev Engineeringmentioning

confidence: 99%

Section: Engineered Evs As Delivery Systems For Cancer-targeted Photothermal Therapymentioning

confidence: 99%

Engineered Extracellular Vesicles for Cancer Therapy

et al. 2021

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“…Exosomes are considered to be natural delivery vesicles that can slow down the endocytosis of macrophages and extend blood circulation time to avoid clearance via the kidney, liver, and the immune system (28), implying that their biocompatibility and transcellular permeability present them as probable vehicles for theranostic applications. Currently, for imaging analysis, the cargo molecules that can be loaded by the exosomes include inorganic molecules (63), magnetic materials (Figure 2C) (59), and fluorescent molecules (64). Besides, there is two main preparation method of exosome theranostics: in-vitro biosynthesis and in-situ biosynthesis.…”

Section: Application In Imaging Examinationsmentioning

confidence: 99%

Exosomes as Smart Nanoplatforms for Diagnosis and Therapy of Cancer

et al. 2021

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Exosomes are composed of a lipid bilayer membrane, containing proteins, nucleic acids, DNA, RNA, etc., derived from donor cells. They have a size range of approximately 30-150 nm. The intrinsic characteristics of exosomes, including efficient cellular uptake, low immunogenicity, low toxicity, intrinsic ability to traverse biological barriers, and inherent targeting ability, facilitate their application to the drug delivery system. Here, we review the generation, uptake, separation, and purification methods of exosomes, focusing on their application as carriers in tumor diagnosis and treatment, especially in brain tumors, as well as the patent applications of exosomes in recent years.

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“…In this study, we developed a tumor-cell-derived exosome-camouflaged porous silicon nanoparticles (E-MSNs) by extrusion method ( Pan et al, 2020 ) as a drug delivery system for co-loading ICG and DOX (ID@E-MSNs), to achieve targeted cancer combined therapy. Compared with ID@MSNs, the biomimetic nanoparticles ID@E-MSNs can be taken up by the tumor cell effectively, which could also enhance tumor accumulation owing to the characteristics of exosome membrane.…”

Section: Introductionmentioning

confidence: 99%

Tumor Exosome Mimicking Nanoparticles for Tumor Combinatorial Chemo-Photothermal Therapy

Tian

Wang

Niu

et al. 2020

Front. Bioeng. Biotechnol.

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The development of biomimetic nanoparticles with functionalities of natural biomaterial remains a major challenge in cancer combination therapy. Herein, we developed a tumor-cell-derived exosome-camouflaged porous silicon nanoparticles (E-MSNs) as a drug delivery system for co-loading ICG and DOX (ID@E-MSNs), achieving the synergistic effects of chemotherapy and photothermal therapy against breast cancer. Compared with ID@MSNs, the biomimetic nanoparticles ID@E-MSNs can be effectively taken up by the tumor cell and enhance tumor accumulation with the help of the exosome membrane. ID@E-MSNs also retain the photothermal effect of ICG and cytotoxicity of DOX. Under 808 nm near infrared irradiation, ICG can produce hyperthermia to collapse E-MSNs nanovehicles, accelerate drug release, and induce tumor ablation, achieving effective chemo-photothermal therapy. In vivo results of 4T1 tumor-bearing BALB/c mice showed that ID@E-MSNs could accumulate tumor tissue and inhibit the growth and metastasis of tumor. Thus, tumor exosome-biomimetic nanoparticles indicate a proof-of-concept as a promising drug delivery system for efficient cancer combination therapy.

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Passion fruit-like exosome-PMA/Au-BSA@Ce6 nanovehicles for real-time fluorescence imaging and enhanced targeted photodynamic therapy with deep penetration and superior retention behavior in tumor

Cited by 113 publications

References 37 publications

Engineered Extracellular Vesicles for Cancer Therapy

Engineered Extracellular Vesicles for Cancer Therapy

Exosomes as Smart Nanoplatforms for Diagnosis and Therapy of Cancer

Tumor Exosome Mimicking Nanoparticles for Tumor Combinatorial Chemo-Photothermal Therapy

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