Engineered Extracellular Vesicles for Cancer Therapy

Zhang, Xu; Zhang, Hongbo; Gu, Jianmei; Zhang, Jiayin; Shi, Hui; Qian, Hui; Wang, Dongqing; Xu, Wenrong; Pan, Jianming; Santos, Hélder A.

doi:10.1002/adma.202005709

Cited by 220 publications

(193 citation statements)

References 180 publications

Supporting

Mentioning

160

Contrasting

Order By: Relevance

“…Compared to natural EVs, the delivery of TOs with engineered EVs are more potential because of their enhanced targeting and customized diversity functions [ 339 ]. Recipient cells can internalize EVs through a variety of pathways, including membrane fusion, receptor-mediated endocytosis, lipid-raft-mediated endocytosis or micropinocytosis.…”

Section: Nanoparticles-based Delivery Of Tosmentioning

confidence: 99%

Delivery of therapeutic oligonucleotides in nanoscale

Zhou

Lin

et al. 2022

Bioactive Materials

Self Cite

View full text Add to dashboard Cite

Therapeutic oligonucleotides (TOs) represent one of the most promising drug candidates in the targeted cancer treatment due to their high specificity and capability of modulating cellular pathways that are not readily druggable. However, efficiently delivering of TOs to cancer cellular targets is still the biggest challenge in promoting their clinical translations. Emerging as a significant drug delivery vector, nanoparticles (NPs) can not only protect TOs from nuclease degradation and enhance their tumor accumulation, but also can improve the cell uptake efficiency of TOs as well as the following endosomal escape to increase the therapeutic index. Furthermore, targeted and on-demand drug release of TOs can also be approached to minimize the risk of toxicity towards normal tissues using stimuli-responsive NPs. In the past decades, remarkable progresses have been made on the TOs delivery based on various NPs with specific purposes. In this review, we will first give a brief introduction on the basis of TOs as well as the action mechanisms of several typical TOs, and then describe the obstacles that prevent the clinical translation of TOs, followed by a comprehensive overview of the recent progresses on TOs delivery based on several various types of nanocarriers containing lipid-based nanoparticles, polymeric nanoparticles, gold nanoparticles, porous nanoparticles, DNA/RNA nanoassembly, extracellular vesicles, and imaging-guided drug delivery nanoparticles.

show abstract

Section: Nanoparticles-based Delivery Of Tosmentioning

confidence: 99%

Delivery of therapeutic oligonucleotides in nanoscale

Zhou

Lin

et al. 2022

Bioactive Materials

Self Cite

View full text Add to dashboard Cite

show abstract

“…EVs play a crucial role in intercellular communication and mediate the pathogenesis, proliferation, immune escape, and metastasis of HCC [ 46 , 47 , 48 ]. As such, EVs are regarded as potential therapeutic agents or vehicles for HCC treatment [ 125 ]. With emerging studies in the field, the EVs’ cargos, including functional proteins, non-coding RNAs, and mRNAs, are promising biomarkers for the detection of early-stage HCC [ 126 ].…”

Section: Conclusion and Future Directionmentioning

confidence: 99%

The Role of Extracellular Vesicles in Disease Progression and Detection of Hepatocellular Carcinoma

Lee

Tran

Wang

et al. 2021

Cancers

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and one of the leading causes of cancer-related death worldwide. Despite the improvements in surveillance and treatment, the prognosis of HCC remains poor. Extracellular vesicles (EVs) are a heterogeneous group of phospholipid bilayer-enclosed particles circulating in the bloodstream and mediating intercellular communication. Emerging studies have shown that EVs play a crucial role in regulating the proliferation, immune escape, and metastasis of HCC. In addition, because EVs are present in the circulation at relatively early stages of disease, they are getting attention as an attractive biomarker for HCC detection. Over the past decade, dedicated efforts have been made to isolate EVs more efficiently and make them useful tools in different clinical settings. In this review article, we provide an overview of the EVs isolation methods and highlight the role of EVs as mediators in the pathogenesis and progression of HCC. Lastly, we summarize the potential applications of EVs in early-stage HCC detection.

show abstract

“…In an effort to mitigate the effects of PAE, extracellular vesicles (EVs) have been of interest due to their involvement in intercellular communication, biocompatibility, low toxicity, and non-immunogenic properties [5,74,75]. EVs are membrane-bound vesicles typically ranging from 50-500 nm that carry proteins, lipids, and nucleic acids between cells and be crucial mediators of cell-to-cell communication and disease pathogenesis (Figure 1) [76,77].…”

Section: Evs and Intercellular Transfer Of Toxicitymentioning

confidence: 99%

“…EVs may be playing significant roles in regulating immune response and tumor diagnosis as nanovesicles for therapeutic agent delivery and special biomarkers, respectively [74,84]. For example, EVs derived from immunosuppressive dendritic cells show a significant effect on animal inflammation and autoimmune diseases [85].…”

Section: Evs and Intercellular Transfer Of Toxicitymentioning

confidence: 99%

Toxic and Teratogenic Effects of Prenatal Alcohol Exposure on Fetal Development, Adolescence, and Adulthood

Chung

Pinson

Bhenderu

et al. 2021

IJMS

View full text Add to dashboard Cite

Prenatal alcohol exposure (PAE) can have immediate and long-lasting toxic and teratogenic effects on an individual’s development and health. As a toxicant, alcohol can lead to a variety of physical and neurological anomalies in the fetus that can lead to behavioral and other impairments which may last a lifetime. Recent studies have focused on identifying mechanisms that mediate the immediate teratogenic effects of alcohol on fetal development and mechanisms that facilitate the persistent toxic effects of alcohol on health and predisposition to disease later in life. This review focuses on the contribution of epigenetic modifications and intercellular transporters like extracellular vesicles to the toxicity of PAE and to immediate and long-term consequences on an individual’s health and risk of disease.

show abstract

Engineered Extracellular Vesicles for Cancer Therapy

Cited by 220 publications

References 180 publications

Delivery of therapeutic oligonucleotides in nanoscale

Delivery of therapeutic oligonucleotides in nanoscale

The Role of Extracellular Vesicles in Disease Progression and Detection of Hepatocellular Carcinoma

Toxic and Teratogenic Effects of Prenatal Alcohol Exposure on Fetal Development, Adolescence, and Adulthood

Contact Info

Product

Resources

About