Parvovirus B19 infection associated with Hashimoto's thyroiditis in adults

Wang, Juanhong; Zhang, Weiping; Liu, Hongxiang; Wang, Di; Wang, Wenqing; Li, Yuanfei; Wang, Zhe; Wang, Lu; Zhang, Wei; Huang, Gaosheng

doi:10.1016/j.jinf.2010.02.006

Cited by 52 publications

(57 citation statements)

References 36 publications

(38 reference statements)

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“…This study also expands the findings of Wang et al (7,16), detecting B19 in PTC and HT tissue samples, with similar results in other types of thyroid tumors. In the B19-positive tissues, we detected a marked change in virus capsid localization between unaffected tissues with only nuclear staining and tumor tissue with strong nuclear as well as cytoplasmic staining.…”

Section: Discussionsupporting

confidence: 90%

“…B19 has also been highly associated with neurological disorders (3,4) and autoimmune disorders with symptoms similar to rheumatoid arthritis and lupus erythematosus (5). The role of B19 in autoimmune thyroid disorders, including Grave's disease (6) and Hashimoto's thyroiditis (HT) (7)(8)(9), has also gained more recent attention. Little data are available on B19-thyroid interactions, but the related virus, minute virus of mice (MVMp), has been more extensively studied.…”

Section: Introductionmentioning

confidence: 99%

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Parvovirus B19 Infection in Hashimoto's Thyroiditis, Papillary Thyroid Carcinoma, and Anaplastic Thyroid Carcinoma

Adamson

Fowler

Clare‐Salzler

et al. 2011

Thyroid

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We extend the data available on B19 detection in the thyroid to show a high correlation of virus in another cohort of PTC and HT at the protein level. We also show, for the first time, B19 infection of much more highly aggressive ATC/undifferentiated tumors. Nuclear to cytoplasmic shift in B19 protein in cancer tissue suggests a possible link between B19 and thyroid cancer pathogenesis/progression.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Parvovirus B19 Infection in Hashimoto's Thyroiditis, Papillary Thyroid Carcinoma, and Anaplastic Thyroid Carcinoma

Adamson

Fowler

Clare‐Salzler

et al. 2011

Thyroid

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show abstract

“…There have been 3 case studies and a fourth group study linking thyroid diseases with B19 [33][34][35][36]. Our laboratory and others have shown that B19 infects the thyroid [37][38][39]. The thyroid's critical role in early neurological development may be altered by B19 infections [40].…”

Section: Infection Of Other Organs and Its Resulting Effect On Brainmentioning

confidence: 99%

How Do Viruses Really Cause Neuropathology?: Is There More to the Story

Hobbs¹,

Waseem²

2016

J Neuroinfect Dis

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Our work has focused over the years on Primate Erythroparvovirus 1 [more commonly known as parvovirus B19 (B19)]. B19 is a human pathogen that is the causative agent of erythema infectiosum, the common rash disease of childhood. In addition to several other human diseases, B19 has also been associated with multiple brain diseases. Those brain diseases include, but are not limited to, encephalitis, encephalopathy, meningitis, meningoencephalitis, ataxia, seizures, and stroke. To date, the association has grown, but causation has not been determined. Several possible mechanisms of pathogenesis including direct infection, indirect/epigenetic, reactivation, and autoimmune/ inflammatory cytotoxicity, as well as effects due to infection of other organs have been suggested. We will also offer other hypotheses.

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“…Çalışmamızda ELISA yöntemi ile Anti-Parvovirus B19 IgM ve IgG antikorları araştırılmış ancak Parvovirus B19 DNA PCR yöntemiyle çalışılamamıştır. Wang ve Mori [22][23] yaptıkları çalışmalarında hashimato tiroiditli dokuda Parvovirüs B19 nükleik asidi ve viral proteinleri göstermişlerdir. Leihman ve arkadaşları [19] Hashimato tiroiditli hastalarda viral DNA, VP1,VP2 ve NS1 proteinlerine karşı antikor arayarak Parvovirüs ile ilişkiyi araştırmışlar ve antikor dü-zeylerinde farklılık bulamamışlardır.…”

Section: Discussionunclassified

The Evaluation of the Relationship Between Parvovirus B19 and Hashimato Thyroiditis

Ece¹

2015

Ann Clin Anal Med

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ÖzetAmaç: Kronik lenfositik tiroidit veya otoimmun tiroidit olarak da bilinen Hashimoto tiroiditinde (HT) tiroid follikullerinin lenfosit ve plazma hücreleri ile tutulumuyla tiroid dokusunda hasar ve atrofi meydana gelmektedir. Hashimoto tiroiditi ile bazı HLA antijen gruplarının birlikteliğinin bildirilmesi bu hastalığın genetik bir yatkınlık zemininde geliştiğini düşündürmektedir. Parvovirüs B19 yaygın görülen ve insanlarda hastalık yapabilen tek zincirli bir DNA virüsüdür. Parvovirüs B 19 enfeksiyonunun otoimmün hastalıkların etiyolojisi veya tetiklenmesinden sorumlu olabileceği düşünülmektedir. Çalışmamızda Hashimato tiroiditi tanısı alan hastaların Parvovirüs B19 ile ilişkisinin araştı-rılması amaçlandı. Gereç ve Yöntem: Çalısmaya hastanemizin dahiliye polikliniğine başvuran ve Hashimato tiroiditi tanısı almış 50 hasta ile kontrol grubu olarak 30 sağlıklı gönüllü alındı. Kontrol ve hasta grubunda Parvovirus B19 IgM ve IgG EIA (Virion/Serion,5 Almanya) yöntemi ile çalışıldı. İstatistiksel sonuçlar İzmir Üniversitesi Tıp Fakültesi Biyoistatistik AD tarafından ki-kare testi ile değerlendirildi. p< 0.05 anlamlı olarak kabul edildi. Bulgular: Çalış-maya dahil edilen toplam 50 Hashimato tiroiditi hastasının üçünde (%6) Parvovirus B19 IgM pozitifliği 36 (%72) hastada ise IgG seropozitifliği saptandı. Kontrol grubunda ise dört hastada IgM (%13.3) pozitifliği, 15 hastada (%50) IgG seropozitifliği saptandı. İstatiksel olarak IgM değerleri açısından hasta ve kontrol grubunda fark bulunmadı (p>0.05). Hasta grubundaki IgG değer-leri ise istatiksel olarak anlamlı yüksek bulundu (p<0.05). Tartışma: Viral enfeksiyonlar birçok otoimmun hastalığın fizyopatolojisinde etkili olabilir. Çalış-mamızda Hashimato tiroiditi olan hastalarda kontrol grubuna göre Parvovirüs B19 IgG seropozitifliği daha yüksek bulundu (p<0.05). Bu sonucun önem-li olduğu ve bu konuda daha fazla hasta sayılarını içeren çalışmalara ihtiyaç olduğu düşüncesindeyiz. Anahtar KelimelerHashimato Tiroditi; Parvovirus B19; Otoimmun Antikor Abstract Aim: Hashimato thyroiditis also known as chronic lymphocytic thyroiditis or autoimmune thyroiditis is characterized by lymphocyte and plasma cell infiltration of thyroid follicles causing destruction and atrophy in thyroid tissue. Reports on coexistence of several HLA antigen types in Hashimoto thyroiditis may indicate genetic predisposition. Parvovirus B19 is a prevalent and single stranded DNA virus that can cause disease in humans. Parvovirus B 19 infection may be responsible for autoimmune disorders or trigger them. The aim of our study was to evaluate the relationship between Parvovirus B19 and Hashimato thyroiditis. Material and Method: Fifity patients with Hashimato thyroiditis that were admitted to our Internal Medicine outpatient clinic and thirty healthy subjects were included in this study. Parvovirus B19 IgM and IgG were studied by EIA (Virion/Serion, Germany). Statistical analysis of the data was studied with chi-square test at Izmir University School of Medicine Department of Biostatistics . p< 0.05 was ac...

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Parvovirus B19 infection associated with Hashimoto's thyroiditis in adults

Cited by 52 publications

References 36 publications

Parvovirus B19 Infection in Hashimoto's Thyroiditis, Papillary Thyroid Carcinoma, and Anaplastic Thyroid Carcinoma

Parvovirus B19 Infection in Hashimoto's Thyroiditis, Papillary Thyroid Carcinoma, and Anaplastic Thyroid Carcinoma

How Do Viruses Really Cause Neuropathology?: Is There More to the Story

The Evaluation of the Relationship Between Parvovirus B19 and Hashimato Thyroiditis

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