Parvovirus B19 antibodies in sera of patients with unexplained exanthemata from Belém, Pará, Brazil

Freitas, Ronaldo Barros de; Miranda, Milton Edson; Shirley, Jane A.; Tudor, Rita; Desselberger, Ulrich; Linhares, Alexandre C.

doi:10.1590/s0074-02761993000300023

Cited by 17 publications

(5 citation statements)

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“…The temporal distribution of B19 infection throughout our study period support the cyclic pattern proposed for the occurrence B19 infections, as recorded by FREITAS et al 21 in Belém, Pará, with peaks of viral activity at 3-5 year intervals. Of note, the high number of arthropathies recorded in 1998 were not associated with the B19 and other bacterial and/or parasitic agents investigated.…”

Section: Discussionsupporting

confidence: 91%

Association between human parvovirus B19 and arthropathy in Belém, Pará, north Brazil

Freitas

Monteiro

Filho

et al. 2002

Rev. Inst. Med. trop. S. Paulo

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A total of 220 patients with arthropathy were selected in Belém, Pará between January 1994 and December 2000, and screened for the presence of human parvovirus B19 IgM and IgG antibodies by enzyme-linked immunosorbent assay (ELISA). A subgroup (n = 132) of patients with high levels of antibodies (either IgM+/IgG+ or IgM-/IgG+) were examined for the presence of DNA by polymerase chain reaction/nested PCR. Recent/active infection (detection of IgM and/or IgG-specific antibodies and presence of viral DNA) was identified in 47.7% of the 132 individuals with arthropathy. In our study, women were significantly more affected (59.7%) than men (35.4%) (P = 0.0006). The age group of 11-20 years (84.6%), among female patients, and 21-30 years (42.1%), among male, were those with the highest incidence rates. The analysis of the temporal distribution of B19-associated arthropaties showed a cyclic pattern, with peak incidence rates occuring at 3-5 year intervals. Significant diference (P = 0.01) was observed when comparing both the highest (39.0%) and the lowest (11.0%) seropositivity rates for the years of 1995 and 2000, respectively. The interfalangial joints of hands and feet were mostly affected, with 50.0% and 48.0% of cases among both women and men, respectively. In a smaller proportion, other joints such as those of knee, ankle, pulse and shoulder were affected. As for the duration, symptoms lasted 1 to 5 days in 54.0% of the individuals, whereas in 46.0% of them the disease lasted 6-10 days, if considered the subgroup (n = 63) of patients with recent/active infection by parvovirus B19. In our study, joint clinical manifestations occurred symmetrically. Our results indicate that B19 may be an important agent of arthropathies in our region, and this underscores the need for specific laboratory diagnosis when treating patients suffering from acute arthropathy, mainly pregnant women.

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Section: Discussionsupporting

confidence: 91%

Association between human parvovirus B19 and arthropathy in Belém, Pará, north Brazil

Freitas

Monteiro

Filho

et al. 2002

Rev. Inst. Med. trop. S. Paulo

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“…Extensive serological surveys among both urban and remote Amazonian communities have revealed a wide range of prevalence rates (Freitas et al, 1990(Freitas et al, , 1993(Freitas et al, , 1999(Freitas et al, , 2002. In this report, we describe the prevalence and relative frequency of erythrovirus genotypes in sera of patients with distinct clinical conditions in the Amazon region.…”

Section: Introductionmentioning

confidence: 78%

Molecular characterization of human erythrovirus B19 strains obtained from patients with several clinical presentations in the Amazon region of Brazil

Freitas

Melo

Oliveira

et al. 2008

Journal of Clinical Virology

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“…During the following years (1988 to 1989) twenty-two laboratory confirmed cases were reported in Belém 14 . Another report from the same area for 1989 to 1990 found just one positive case out of 42 13 . We are now reporting 27 (2.5%) anti-B19 IgM positive cases among 1095 cases reported as measles in RJ and ES states during the years 1992 to 1994.…”

Section: Discussionmentioning

confidence: 93%

Human parvovirus B19 infections among exanthematic diseases notified as measles

Cubel

Siqueira²,

Santos³

et al. 1997

Rev. Soc. Bras. Med. Trop.

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A total of 1397 sera collected from 1095 cases of exanthematic disease notified as measles in ES and RJ states during July 1992 to December 1994 were investigated. These sera were first tested for measles and rubella specific IgM. When they proved negative, they were tested for B19 specific IgM by an enzyme immunoassay. B19 infection was confirmed in 27 (2.5%) of these cases. Sera from 194 negative cases for measles and rubella IgM received from other Brazilian states were also investigated and B19 infection was confirmed for 11 of them. Sera from these 38 IgM positive cases for B19, were tested for anti-B19 IgG by an enzyme immunoassay and for B19 DNA by dot blot hybridization. Anti-B19 IgG antibodies were detected in most of the acute sera. B19 DNA was detected in the acute serum of one patient that had been splenectomized before. As the exanthem caused by human parvovirus infection may be clinically diagnosed as rubella, it could be important to diagnose B19 infection in Brazil since it is becoming prevalent as the cause of rash in countries where rubella is controlled by vaccination.
Um total de 1397 soros colhidos de 1095 casos de exantema notificados como sarampo, nos estados do ES e RJ, no período de julho de 1992 a dezembro de 1994, foram investigados. Estes soros foram inicialmente testados para sarampo e rubéola por detecção de IgM específica. Os casos negativos foram então testados para a presença de IgM específca anti-B19 por um ensaio imunoenzimático. A infecção pelo B19 foi confirmada em 27 (2,5%) destes casos. Soros de 194 casos negativos para sarampo e rubéola provenientes de outros estados brasileiros foram também investigados, e a infecção pelo B19 pode ser confirmada em 11 destes casos. Os soros dos 38 casos IgM positivos para B19 foram testados para a presença de IgG específica anti-B19 por um ensaio imunoenzimático, e para a presença do ADN viral por hibridização em "dots" (dot blot). IgG específica anti-B19 pode ser detectada na maioria dos soros de fase aguda, e o ADN viral foi detectado no soro de fase aguda de um paciente esplenectomizado. Como o exantema causado pela infecção pelo parvovírus humano pode ser clinicamente diagnosticado como rubéola, seria importante realizar o diagnóstico desta virose no Brasil, já que um aumento no número de casos de exantema por B19 tem sido relatado nos países onde a rubéola é controlada por vacinação

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Parvovirus B19 antibodies in sera of patients with unexplained exanthemata from Belém, Pará, Brazil

Cited by 17 publications

References 0 publications

Association between human parvovirus B19 and arthropathy in Belém, Pará, north Brazil

Association between human parvovirus B19 and arthropathy in Belém, Pará, north Brazil

Molecular characterization of human erythrovirus B19 strains obtained from patients with several clinical presentations in the Amazon region of Brazil

Human parvovirus B19 infections among exanthematic diseases notified as measles

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