Molecular characterization of human erythrovirus B19 strains obtained from patients with several clinical presentations in the Amazon region of Brazil

Freitas, Ronaldo Barros de; Melo, Fernando Lucas; Oliveira, Darleise de Souza; Romano, Camila Malta; Freitas, Maria Rute Castro de; Macêdo, Olinda; Linhares, Alexandre da Costa; Zanotto, Paolo Marinho de Andrade; Durigon, Edison Luíz

doi:10.1016/j.jcv.2008.03.033

Cited by 47 publications

(53 citation statements)

References 27 publications

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“…All three genotypes have been identified in Brazil, although genotype 1 is the most common (Sanabani et al 2006, Freitas et al 2008, Keller et al 2009, Garcia 2010). Genotype 3b was identified in a serum sample obtained from a patient with systemic lupus erythematosus in 1999 in Belém, state of Pará (Freitas et al 2008); in a sample from a patient from São Paulo, state of São Paulo, with anaemia after a kidney transplantation in 2004 (Keller et al 2009) and in children with exanthaematic disease (Freitas et al 2008). …”

Section: Discussionmentioning

confidence: 99%

Clinical features and laboratory findings of human parvovirus B19 in human immunodeficiency virus-infected patients

Pereira

Garcia

Azevedo

et al. 2014

Mem. Inst. Oswaldo Cruz

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Immunocompromised patients may develop severe chronic anaemia when infected by human parvovirus B19 (B19V). However, this is not the case in human immunodeficiency virus (HIV)-infected patients with good adherence to highly active antiretroviral treatment (HAART). In this study, we investigated the clinical evolution of five HIV-infected patients receiving HAART who had B19V infections confirmed by serum polymerase chain reaction. Four of the patients were infected with genotype 1a strains and the remaining patient was infected with a genotype 3b strain. Anaemia was detected in three of the patients, but all patients recovered without requiring immunoglobulin and/or blood transfusions. In all cases, the attending physicians did not suspect the B19V infections. There was no apparent relationship between the infecting genotype and the clinical course. In the HAART era, B19V infections in HIV-positive patients may be limited, subtle or unapparent.

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Section: Discussionmentioning

confidence: 99%

Clinical features and laboratory findings of human parvovirus B19 in human immunodeficiency virus-infected patients

Pereira

Garcia

Azevedo

et al. 2014

Mem. Inst. Oswaldo Cruz

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“…All B19V genotypes appear to cocirculate, but their relative frequency is strikingly different and their spatial and temporal distribution is not uniform [24][25][26][27][28]. The prototype genotype 1a is the major circulating genotype and is present in all geographic areas [27].…”

Section: Evolutionmentioning

confidence: 99%

Parvovirus B19 Achievements and Challenges

Gallinella

2013

ISRN Virology

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Parvovirus B19 is a widespread human pathogenic virus, member of the Erythrovirus genus in the Parvoviridae family. Infection can be associated with an ample range of pathologies and clinical manifestations, whose characteristics and outcomes depend on the interplay between the pathogenetic potential of the virus, its adaptation to different cellular environments, and the physiological and immune status of the infected individuals. The scope of this review is the advances in knowledge on the biological characteristics of the virus and of virus-host relationships; in particular, the interactions of the virus with different cellular environments in terms of tropism and ability to achieve a productive replicative cycle, or, on the contrary, to establish persistence; the consequences of infection in terms of interference with the cell physiology; the process of recognition of the virus by the innate or adaptive immune system, hence the role of the immune system in controlling the infection or in the development of clinical manifestations. Linked to these issues is the continuous effort to develop better diagnostic algorithms and methods and the need for development of prophylactic and therapeutic options for B19V infections.

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“…3 Genotype 3 was the only human Erythrovirus genotype detected in 13 DNA positive blood samples from 1000 volunteer blood donors in Ghana. 20 Hubschen et al 14 also found B19V genotype 3 in Western Africa, with a gradual spread to other continents that was confirmed by reports from France, 12 the United Kingdom, 21 Germany, 17 Brasil, 22,23 and the United States. 24 This can either be due to traveling and migration or to the increased awareness and improved techniques of detection.…”

Section: Similar and Contrasting Cases In The Literature And Discussionmentioning

confidence: 81%

Human parvovirus B19 genotype 3 associated with chronic anemia after stem cell transplantation, missed by routine PCR testing

Knoester

Borne

Vossen

et al. 2012

Journal of Clinical Virology

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Molecular characterization of human erythrovirus B19 strains obtained from patients with several clinical presentations in the Amazon region of Brazil

Cited by 47 publications

References 27 publications

Clinical features and laboratory findings of human parvovirus B19 in human immunodeficiency virus-infected patients

Clinical features and laboratory findings of human parvovirus B19 in human immunodeficiency virus-infected patients

Parvovirus B19 Achievements and Challenges

Human parvovirus B19 genotype 3 associated with chronic anemia after stem cell transplantation, missed by routine PCR testing

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