Parvovirus B19 antibodies and correlates of infection in pregnant women attending an antenatal clinic in central Nigeria

Emiasegen, Samuel E; Nimzing, L; Adoga, Moses P; Ohagenyi, Adamu Y; Lekan, Rufai

doi:10.1590/s0074-02762011000200018

Cited by 24 publications

(34 citation statements)

References 19 publications

(24 reference statements)

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“…Although this is in contrast to another study from sub-Saharan Africa with prevalence rates for PB19 IgM of 13.2% and IgG of 27.5% [25], absence of antibodies in 20% in our cohort makes them susceptible to primary infection. Similarly, we documented absence of antibodies against rubella virus in 15.7% of women in our cohort indicated that a significant proportion was susceptible to primary infection during pregnancy.…”

Section: Discussioncontrasting

confidence: 99%

Prevalence of pregnancy-relevant infections in a rural setting of Ghana

Völker

Cooper²,

Bader

et al. 2017

BMC Pregnancy Childbirth

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BackgroundAlthough infectious diseases still account for a high burden of morbidity and mortality in sub-Saharan Africa, simultaneous investigations on multiple infections affecting maternal and child health are missing.MethodsWe conducted a cross-sectional, single-centre pilot study in a rural area of Ghana to assess the infectiological profile during pregnancy. Screening of 180 expectant mothers was done by vaginal swabs and serology to detect the most common pregnancy-relevant infections. They were also interviewed for potential risk factors, outcome of previous pregnancies, and socio-economic aspects.ResultsWe found a high prevalence of infections caused by hepatitis B virus (16.7% HBs antigen positive). In contrast, infections caused by hepatitis C virus (1.1% anti-HCV) and HIV (0.6%) were rare. Maternal malaria was frequent (10.6%), despite increasing acceptance of intermittent preventive treatment during pregnancy (IPTp). Group B streptococci were present in 10.6% of all pregnant women. Absence of antibodies against varicella zoster virus in 43.2%, Toxoplasma gondii in 26.8%, parvovirus B19 in 20.0%, and rubella virus in 15.7% makes a significant proportion of pregnant women susceptible for acquiring primary infections. Whereas all study participants had specific IgG antibodies against human cytomegalovirus, infections with Listeria, Brucella, or Neisseria gonorrhoeae as well as active syphilis were absent.ConclusionsOur pilot study in a rural community in Ghana indicates an urgent need for action in dealing at least with high-prevalent pregnancy-relevant infections, such as hepatitis B, malaria and those caused by group B streptococci. In addition, the resulting prevalence rates of various other infections may offer guidance for health officials to prioritize possible future intervention schemes.Electronic supplementary materialThe online version of this article (doi:10.1186/s12884-017-1351-3) contains supplementary material, which is available to authorized users.

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Section: Discussioncontrasting

confidence: 99%

Prevalence of pregnancy-relevant infections in a rural setting of Ghana

Völker

Cooper²,

Bader

et al. 2017

BMC Pregnancy Childbirth

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“…This finding is similar to that of a recent study in Jos, north central Nigeria, where the prevalence of parvovirus B19 IgG antibody among pregnant women was 27.5% [14]. These findings further indicate that the virus is endemic among pregnant women in Nigeria.…”

Section: Discussionsupporting

confidence: 91%

Seroprevalence of parvovirus B19 IgG and IgM antibodies among pregnant women in Oyo State, Nigeria

Iyanda

Opaleye

Ojurongbe

et al. 2013

J Infect Dev Ctries

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Introduction: Human parvovirus B19 causes a wide range of complications in pregnant women including abortion, severe fetal anemia, nonimmune hydrops fetalis, and even intrauterine fetal death. However, there is a dearth of information on the prevalence of the virus among pregnant women in southwestern Nigeria. Methodology: Blood samples were collected from 231 pregnant women and screened for antibodies to human parvovirus B19 IgM and IgG using an enzyme immunosorbent assay kits. Results: Of the 231 women, 31 were in their first trimester, 146 were in their second trimester, and 54 were in their third trimester. Forty-five (20%) were positive for parvovirus B19 IgG antibodies, 10 (4%) were positive for parvovirus B19 IgM antibodies, and 176 (76%) had no detectable parvovirus B19 antibodies. Twenty-eight (19%) of the 146 pregnant women in their second trimester were positive for parvovirus B19 IgG antibody while three (2%) of the 146 were positive for parvovirus B19 IgM antibody. Conclusions: It is evident that there is a high prevalence of human parvovirus B19 among pregnant women in south-western Nigeria. This suggests that there is an active transmission of the virus in the community; it is therefore necessary to conduct more studies on the virus in pregnant women in Nigeria to ascertain its effect on the fetus.

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“…The most important findings in this study was that more than half of pregnant women were B19 IgG sero-positive with more than a third of them being B19 IgM sero-positive indicating recent infections. The overall prevalence of both IgM and IgG antibodies which signifies true B19 recent infections was found to be slightly higher compared to many other studies [16–20]. A slightly higher rate in this study could be due to variations in the geographical location, weather and season.…”

Section: Discussioncontrasting

confidence: 72%

“…In developing countries; the epidemiology of B19 particularly in pregnant women is not well documented. Seroprevalence of IgM among pregnant women has been found to range between 3.3% in South Africa and 13.2% in Nigeria [16] while that of IgG was found to range from 24.9% in South Africa to 58.4% in Malawi [17]. …”

Section: Introductionmentioning

confidence: 99%

The magnitude and correlates of Parvovirus B19 infection among pregnant women attending antenatal clinics in Mwanza, Tanzania

Mirambo

Maliki

Majigo

et al. 2017

BMC Pregnancy Childbirth

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BackgroundHuman parvovirus B19 (B19) infection has been associated with congenital infection which may result into a number of the adverse pregnancy outcomes. The epidemiology and the magnitude of B19 infections among pregnant women have been poorly studied in developing countries. This study was done to establish preliminary information about the magnitude of B19 among pregnant women attending antenatal clinics in the city of Mwanza, Tanzania.MethodsA cross-sectional study was conducted between December 2014 and June 2015 among 258 pregnant women attending two antenatal clinics representing rural and urban areas in the city of Mwanza. Socio-demographic data were collected using structured data collection tool. Specific B19 IgM and IgG antibodies were determined using indirect enzyme linked immunosorbent assay kits (DRG Instruments GmbH, Germany). Data were analyzed using STATA version 11 software.ResultsThe median age of study participants was 21 IQR (19–25) years. Of 253 pregnant women; 116(44.96%), 109(42.25%) and 33(12.79%) were in the first, second and third trimester respectively. The majority 168(66.4%) of women were from urban areas. Of 253 pregnant women, the overall prevalence of IgM was 83(32.8%) while that of IgG was 142(55.0%) among 258 women tested. A total of 50(19.4%) women were positive for both IgG and IgM indicating true IgM positive. History of baby with low birth weight (OR: 10, 95% CI: 1.82–58.05, P = 0.01) was independent predictor of B19 IgG seropositivity and being at the third trimester was protective (OR: 0.38, 95% CI: 0.16–0.92, P = 0.03). The IgG titers were found to decrease significantly as gestational age increases (Spearman’s rho = −0.2939, p = 0.0004)ConclusionMore than a half of pregnant women in Mwanza city are B19 IgG sero-positive with about one third of these being B19 IgM seropositive. Further studies to determine the impact of B19 infections among pregnant women and their newborns are recommended in developing countries.

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Parvovirus B19 antibodies and correlates of infection in pregnant women attending an antenatal clinic in central Nigeria

Cited by 24 publications

References 19 publications

Prevalence of pregnancy-relevant infections in a rural setting of Ghana

Prevalence of pregnancy-relevant infections in a rural setting of Ghana

Seroprevalence of parvovirus B19 IgG and IgM antibodies among pregnant women in Oyo State, Nigeria

The magnitude and correlates of Parvovirus B19 infection among pregnant women attending antenatal clinics in Mwanza, Tanzania

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