Parvovirus B19 and Hemodialysis

Guiserix, J; Ramdane, Mohamed; Hoarau, Johny; Finielz, Paul; Michault, Alain

doi:10.1159/000188974

Cited by 7 publications

(6 citation statements)

References 4 publications

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“…Nevertheless, there are several reasons to think that parvovirus may be an important pathogen in these populations, since anemia is a common consequence of B19V infection and is also a predictable consequence of chronic renal insufficiency (Kazmi et al, 2001). Although the prevalence of severe anemia is high at the onset of dialysis, and the early presence of anemia in end-stage renal disease (ESRD) is associated with a greater rate of subsequent hospitalization and mortality (Ma et al, 1999), many studies have not found a significant association between anemia and B19V DNA detection in dialysis patients (Guiserix et al, 1996;Sharif et al, 2016;Alves et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Anemia is a common complication of CKD due to: reduced production of erythropoietin by the kidney; significantly decreased erythrocyte survival and iron deficiency; chronic uremic condition; and mineral bone disease caused by distrupted vitamin D, calcium, and phosphate metabolism (Guiserix et al, 1996;Duranay et al, 1998). Persistent B19V infection in these dialyzed patients after renal transplantation and immunosuppressive therapy can manifest as transient aplastic crisis or chronic anemia (Adamson-Small et al, 2014;Eid et al, 2013;Söderlund-Venermo et al, 2002;Norja et al, 2006;Waldman and Kopp, 2007).…”

Section: Introductionmentioning

confidence: 99%

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High prevalence of parvovirus B19 infection in patients with chronic kidney disease under hemodialysis: A multicenter study

Alves

Langella

Barbosa

et al. 2020

International Journal of Infectious Diseases

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Objectives: Parvovirus B19 (B19V) infection is commonly acute and self-limited, but in chronic kidney disease (CKD) patients under dialysis treatment, this infection could increase susceptibility to acute and chronic anemia. The aim of this study was to evaluate the frequency and risk of B19V infection among Brazilian CKD patients under dialysis. Methods: A study was conducted among 221 CKD patients and a control group of 142 blood donors. B19V infection was evaluated in serum samples by real-time PCR, and ELISA (anti-B19V IgM and IgG). Results: B19V DNA was detected in 65% (145/221) of CKD patients, which was significantly higher (p < 0.001) than in the blood donors (6.3%). Simultaneous detection of B19V IgG and viremia was shown in 40.3% of CKD patients, which was indicative of persistent B19V infection. CKD patients showed an increased risk of developing B19V infection (OR = 28.1, CI = 13.5-58.5, p = 0.001). Conclusions: Despite an absence of clinical signs of B19V infection, these data highlight the importance of B19V infection in this high-risk population, since a persistent B19V infection could become clinically significant after renal transplant. Moreover, the persistent viremia should be considered as a potential risk, mainly because of the contamination of dialysis equipment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High prevalence of parvovirus B19 infection in patients with chronic kidney disease under hemodialysis: A multicenter study

Alves

Langella

Barbosa

et al. 2020

International Journal of Infectious Diseases

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“…In a study on 62 hemodialyzed patients, Guiserix et al [36] reported that B19 infections play no role in leading chronic anemia in these subjects. Moreover, there was no correlation between time on dialysis and IgG antibodies.…”

Section: Discussionmentioning

confidence: 99%

Frequency and Genotype of Human Parvovirus B19 among Iranian Hemodialysis and Peritoneal Dialysis Patients

Sharif

Aghakhani²,

Velayati³

et al. 2016

Intervirology

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Objectives: The aim of this study was to evaluate the frequency and genotype of human parvovirus B19 and its relation with anemia among Iranian patients under dialysis. Methods: Fifty hemodialysis (HD) and 33 peritoneal dialysis (PD) patients were enrolled. B19 IgG and IgM antibodies were assessed by ELISA, and the presence of B19 DNA was evaluated by nested PCR. PCR products were sequenced directly and phylogenetic analysis was performed. Results: In the HD group, the prevalence of B19 antibodies was 54% for IgG and 4% for IgM. B19 DNA was detected in 10% of the cases, and 10% showed B19 IgG and viremia simultaneously. In the PD group, the prevalence of B19 IgG and IgM was 57.6 and 0% respectively, whereas B19 DNA was found in 12.1% of the group. A total of 9.1% showed B19 IgG and viremia concurrently. There was no significant difference regarding anemia and B19 infection in either group. All B19 isolates were clustered in genotype 1A. Conclusion: Our findings indicate that B19 infection plays no role in leading chronic anemia in dialysis patients. However, persistent B19 viremia and the circulation of the same strains in dialysis patients may indicate a potential risk for the contamination of dialysis equipment and nosocomial spread of B19 infection within dialysis units.

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“…Although some cases of B19 infection in patients undergoing dialysis have been reported, there are few studies which evaluated the incidence and clinical significance of B19 infection in these patients. 48–50 Generally, this viral infection has been associated with transient aplastic crisis and unresponsiveness to treatment with rHuEPO. 46,51 However, several studies have reported the occurrence of acquired pure red cell aplasia (PRCA) and severe transfusion-dependent anemia in kidney transplant patients infected by B19.…”

Section: Causes Of Resistance To Treatment With Recombinant Human Erymentioning

confidence: 99%

Resistance of dialyzed patients to erythropoietin

Alves

Vilaça

Carvalho

et al. 2015

Revista Brasileira de Hematologia e Hemoterapia

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Resistance to recombinant human erythropoietin is a common condition in dialyzed patients with chronic kidney disease and is associated with more hospitalizations, increased mortality and frequent blood transfusions. The main cause of hyporesponsiveness to recombinant human erythropoietin in these patients is iron deficiency. However, a high proportion of patients does not respond to treatment, even to the use of intravenous iron, which indicates the presence of other important causes of resistance. In addition to the iron deficiency, the most common causes of resistance include inflammation, infection, malnutrition, inadequate dialysis, and hyperparathyroidism, although other factors may be associated. In the presence of adequate iron stores, other causes should be investigated and treated appropriately.

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Parvovirus B19 and Hemodialysis

Cited by 7 publications

References 4 publications

High prevalence of parvovirus B19 infection in patients with chronic kidney disease under hemodialysis: A multicenter study

High prevalence of parvovirus B19 infection in patients with chronic kidney disease under hemodialysis: A multicenter study

Frequency and Genotype of Human Parvovirus B19 among Iranian Hemodialysis and Peritoneal Dialysis Patients

Resistance of dialyzed patients to erythropoietin

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