Parvoviral Enteritli Köpeklerde Pıhtılaşma Profilleri ve Kalp Biyomarkır Düzeyleri

Er, Cenk; Ok, Mahmut

doi:10.9775/kvfd.2014.12575

Cited by 2 publications

(5 citation statements)

References 28 publications

(44 reference statements)

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“…This dramatic increase in fibrinogen level might be related to an elevation in acute phase proteins in spite of the presence of DIC in dogs with sepsis. Therefore, our findings were in line with findings of earlier reporters [46][47][48] .…”

Section: Discussionsupporting

confidence: 93%

“…Our results were in line with previous studies [2,21,[42][43][44][45] . Some authors [46][47][48] reported that the level of fibrinogen might increase in the first period of DIC due to an inflamatory response; and then this level might decrease because of fibrinolisis. In contrast, other researchers [19,45] reported a significant decrease in fibrinogen level.…”

Section: Discussionmentioning

confidence: 99%

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Sepsisli Köpeklerde Akut Faz Proteinler, Bazı Sitokinler ve Hemostatik Parametrelerin Değerlendirilmesi

Ok¹,

Er²,

Yıldız³

et al. 2015

Kafkas Univ Vet Fak Derg

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The aim of this study was to evaluate the alterations in acute phase proteins, cytokines and hemostatic parameters in dogs with sepsis and to determine the importance of these parameters in diagnosis of the sepsis. Thirty dogs with sepsis and 9 healthy dogs were used in this study. Anorexia, depression, lethargy, hyperthermia, tachycardia, tachypnea, congestion in the mucosal membranes, prolonged capillary refill time, and leukocytosis or leucopenia were identified in the dogs with sepsis. The serum interleukin-1ß (IL-1ß), tumor necrosis factor α (TNF-α), interferon γ (INF-γ), C-reactive protein (CRP), serum amyloid A (SAA), prothrombin time (PT), activated partial thromboplastin time (aPTT), antithrombin III (AT III), fibrinogen, protein C (PC), and D-dimer levels were measured in all dogs. We found that the serum IL-1ß, TNF-α, INF-γ, CRP and SAA concentrations were significantly elevated in dogs with sepsis as compared with healthy controls. In addition, the plasma PT and APTT levels were notably prolonged, the plasma fibrinogen, D-dimers and protein C concentrations were significantly increased. However, the antithrombin III activity was significantly decreased in the dogs with sepsis. In conclusion, the results of this study indicate that the SAA, IL-1ß and TNF-α parameters play important roles in the inflammatory process in dogs with sepsis. The hemostatic abnormalities observed in dogs with sepsis may be due to the development of disseminated intravascular coagulation (DIC). Keywords:

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Sepsisli Köpeklerde Akut Faz Proteinler, Bazı Sitokinler ve Hemostatik Parametrelerin Değerlendirilmesi

Ok¹,

Er²,

Yıldız³

et al. 2015

Kafkas Univ Vet Fak Derg

Self Cite

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“…Many differences have been reported as a result of hematological analyzes performed in dogs with CDV or CPV [9,16,17,20,32,34]. In addition to hematological analyzes, blood gases measurements are reported to be useful diagnostic and prognostic methods that are frequently used both for tentative diagnosis and confirmation of the diagnosis [8,14,22].…”

Section: Figure 1 Roc Analysis Of Wbc (A) Granulocyte (B) and MCV (C)...mentioning

confidence: 99%

“…This persistence causes erythroid hypoplasia and explains the anemia detected in CDV-infected dogs [17]. In addition, the fact that iron becomes less useful for the body as a result of the release of interleukin-6 also contributes to the formation of anemia [16,31].…”

Section: Figure 1 Roc Analysis Of Wbc (A) Granulocyte (B) and MCV (C)...mentioning

confidence: 99%

“…Two important viral infections that usually cause hemorrhagic gastroenteritis in dogs are Canine Parvovirus (CPV) [20] and Canine Distemper virus (CDV) [6]. CPV infection is an acute, contagious and fatal viral disease that can cause both hemorrhagic gastroenteritis and myocarditis, which is more common in puppies less than 8 weeks (w) old [16,22,31]. Although severe clinical findings are mostly seen in dogs younger than 6 months (mos), adult dogs with immunosuppression are also potentially at risk [35].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Efficacy of Blood Gases and Hemogram Parameters in the Diagnosis of non Neurogenic Distemper and Parvoviral Enteritis in Dogs with Acute Gastroenteritis

et al. 2022

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Canine parvovirus (CPV) and canine distemper virus (CDV), which are seen mostly in dogs younger than 6 months (mos) old with high mortality despite early diagnosis and treatment, cause various hematological abnormalities and clinical symptoms accompanied by gastroenteritis findings. Since the methods developed for definitive ante-mortem diagnosis are time-consuming and require expertise and equipment, routine laboratory tests such as blood gases and hemogram analyzes still maintain their importance in the diagnosis and monitoring the complications associated with the viruses. The animal material of the study was consisted of a total of 50 dogs: 40 dogs (Experimental Group; 24 male, 16 female) aged between 2-6 mos, from medium to large breeds such as Anatolian shepherd, Boxer and mixed breed with gastroenteritis symptoms; 10 healthy dogs (Control Group; 8 male, 2 female) aged between 2-6 mos, from similar breeds. All were brought to the hospital either for diagnosis/treatment or for routine check-up. Based on the results of rapid antigen tests performed following the clinical and laboratory analyzes, the Experimental Group was divided into two subgroups: Canine Parvovirus Group (CPV Group, n=22) and Canine Distemper Virus Group (CDV Group, n=18). As a result of laboratory analyzes, differences in respiratory rate, capillary refill time and body temperature (P=0.000) in the clinical examinations; leukocyte (WBC) (P=0.003), granulocyte (P=0.000) and mean corpuscular volume (MCV) (P=0.001) levels in the hemogram; pH (P=0.001), lactate (P=0.004) and HCO3 (P=0.001) levels in the blood gases analysis were detected in the CPV and CDV groups. Based on the Receiver operating characteristic (ROC) evaluation of the parameters, which were determined to vary in the Experimental Group, it was concluded that low pH and HCO3 with high lactate levels in blood gases along with low WBC, granulocyte and high MCV levels in the hemogram may be useful parameters in establishing a routine laboratory test panel for diferentiation between CPV and CDV.

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Parvoviral Enteritli Köpeklerde Pıhtılaşma Profilleri ve Kalp Biyomarkır Düzeyleri

Cited by 2 publications

References 28 publications

Sepsisli Köpeklerde Akut Faz Proteinler, Bazı Sitokinler ve Hemostatik Parametrelerin Değerlendirilmesi

Sepsisli Köpeklerde Akut Faz Proteinler, Bazı Sitokinler ve Hemostatik Parametrelerin Değerlendirilmesi

Evaluation of the Efficacy of Blood Gases and Hemogram Parameters in the Diagnosis of non Neurogenic Distemper and Parvoviral Enteritis in Dogs with Acute Gastroenteritis

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