Parvalbumin-immunoreactive neurons in the human central nervous system are decreased in Alzheimer's disease

Satoh, Jun‐ichi; Tabira, Takeshi; Sano, Masaaki; Nakayama, Hiroshi; Tateishi, Jun

doi:10.1007/bf00293459

Cited by 87 publications

(36 citation statements)

References 39 publications

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“…Receptor binding for GABA was significantly reduced in the FC of AD brains compared to controls with no significant alterations in the hippocampus [27,28,29]. In addition, a decrease in parvalbumin-immunoreactive cortical pyramidal neurons was reported [30]. However, other studies showed a relative resistance of these cells [31,32] and the presence of parvalbumin-immunoreactive abnormal neuritis and aberrant sprouts [33].…”

Section: Discussionmentioning

confidence: 97%

Decrease of GABAergic Markers and Arc Protein Expression in the Frontal Cortex by Intraventricular 192 IgG-Saporin

Jeong¹,

Chang²,

Hwang³

et al. 2011

Dement Geriatr Cogn Disord

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Background/Aims: Previous studies used 192 IgG-saporin to study cholinergic function because of its facility for selective lesioning; however, results varied due to differences in the methods of administration and behavioral tests used. We examined an animal model of dementia using 192 IgG-saporin to confirm its features before applying this model to research of therapeutic drugs or electrical stimulation techniques. Methods: Features were verified by the Morris water maze test, immunochemistry, and Western blotting. Animals were examined after intraventricular injection of 192 IgG-saporin (0.63 µg/µl; 6, 8, and 10 µl) or phosphate-buffered saline. Results: In the acquisition phase of the Morris water maze test, the latencies of the injection groups were significantly delayed, but recovered within 1 week. In the probe test, 2 of 4 indices (time in the platform zone and the number of crossings) were significantly different in the 8-µl injection group. Immunohistochemistry revealed the extent of cholinergic destruction. Activity-regulated cytoskeleton-associated protein and glutamate decarboxylase expression significantly decreased in the frontal cortex (8- and 10-µl groups), but not in the hippocampus. Conclusion: Spatial memory impairment was associated with cholinergic basal forebrain injury as well as frontocortical GABAergic hypofunction and synaptic plasticity deceleration.

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Section: Discussionmentioning

confidence: 97%

Decrease of GABAergic Markers and Arc Protein Expression in the Frontal Cortex by Intraventricular 192 IgG-Saporin

Jeong¹,

Chang²,

Hwang³

et al. 2011

Dement Geriatr Cogn Disord

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“…Changes in morphology, density, and size of PV-immunoreactive neurons, associated with neurodegenerative disease and aging, have been reported in brains of the rat, hamster, and human (Seto-Ohshima et al 1988;Seki and Arai 1995;de Jong et al 1996). No significant changes of PV-immunoreactive neurons have been described in the cerebellar cortex of humans or the cerebellum and reticular thalamic nucleus of the hamster (Satoh et al 1991;Lolova and Davidoff 1992). However, a loss of PV-immunoreactive neurons has been reported in the normal aged hippocampus and olfactory bulb (Seki and Arai 1995;Hwang et al 2003).…”

Section: Age-related Changes Of Cabpsmentioning

confidence: 93%

Age-related Changes in Calbindin-D28k, Parvalbumin, and Calretinin Immunoreactivity in the Dog Main Olfactory Bulb

et al. 2009

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Expression and age-related changes of calbindin-D28k (CB), parvalbumin (PV), and calretinin (CR) in the main olfactory bulb of the dog were investigated by immunohistochemistry and western blot analysis. Neurons that expressed these calcium-binding proteins showed a characteristic laminar distribution. Most of CB-immunoreactive neurons were observed in the glomerular layer (GL) and the inner sublayer of the external plexiform layer (EPL). Most of PV-immunoreactive neurons were observed in the outer sublayer of the EPL. CR-immunoreactive neurons were mainly distributed in the GL and the granule cell layer. With regard to age-related changes, CB-immunoreactive neurons in the GL were stable among all age groups; however, in the EPL they decreased with age. PV-immunoreactive neurons decreased in middle-aged and aged groups. However, CR-immunoreactive neurons were not decreased in middle-aged and aged groups. These results suggest that CB-immunoreactive neurons in the EPL were most sensitive to aging, and that their reduction may be related to aging in the dog.

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“…The present data were taken from an animal 21 years of age [owl monkeys reportedly live to more than 27 years of age; Nowak, 1999]. However, various studies have demonstrated that there is no decrease in the number of inhibitory interneurons and their axon terminals in the normal aging brain [Ichimiya et al, 1988;Hof and Morrison, 1991;Satoh et al, 1991;Leuba et al, 1998]. …”

Section: Methodological Limitations: Animal and Areas Included For Studymentioning

confidence: 99%

Parvalbumin-, Calbindin-, and Calretinin-Immunoreactive Neurons in the Prefrontal Cortex of the Owl Monkey <i>(Aotus trivirgatus)</i>: A Standardized Quantitative Comparison with Sensory and Motor Areas

Elston¹,

González-Albo²

2003

Brain Behav Evol

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Recent studies have revealed regional variation in the density and distribution of inhibitory neurons in different cortical areas, which are thought to reflect area-specific specializations in cortical circuitry. However, there are as yet few standardized quantitative data regarding how the inhibitory circuitry in prefrontal cortex (PFC), which is thought to be involved in executive functions such as cognition, emotion and decision making, compares to that in other cortical areas. Here we used immunohistochemical techniques to determine the density and distribution of parvalbumin (PV)-, calbindin (CB)-, and calretinin (CR)-immunoreactive (ir) neurons and axon terminals in the dorsolateral and orbital PFC of the owl monkey (Aotus trivirgatus), and compared them directly with data obtained using the same techniques in 11 different visual, somatosensory and motor areas. We found marked differences in the density of PV-ir, CB-ir, and CR-ir interneurons in several cortical areas. One hundred and twenty eight of all 234 possible between-area pair-wise comparisons were significantly different. The density of specific subpopulations of these cells also varied among cortical areas, as did the density of axon terminals. Comparison of PFC with other cortical areas revealed that 40 of all 66 possible statistical comparisons of the density of PV-ir, CB-ir, and CR-ir cells were significantly different. We also found evidence for heterogeneity in the pattern of labeling of PV-ir, CB-ir, and CR-ir cells and axon terminals between the dorsolateral and orbital subdivisions of PFC. These data are likely to reflect basic differences in interneuron circuitry, which are likely to influence inhibitory function in the cortex.

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Parvalbumin-immunoreactive neurons in the human central nervous system are decreased in Alzheimer's disease

Cited by 87 publications

References 39 publications

Decrease of GABAergic Markers and Arc Protein Expression in the Frontal Cortex by Intraventricular 192 IgG-Saporin

Decrease of GABAergic Markers and Arc Protein Expression in the Frontal Cortex by Intraventricular 192 IgG-Saporin

Age-related Changes in Calbindin-D28k, Parvalbumin, and Calretinin Immunoreactivity in the Dog Main Olfactory Bulb

Parvalbumin-, Calbindin-, and Calretinin-Immunoreactive Neurons in the Prefrontal Cortex of the Owl Monkey <i>(Aotus trivirgatus)</i>: A Standardized Quantitative Comparison with Sensory and Motor Areas

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