Particulate matter air pollution components and risk for lung cancer

Raaschou-Nielsen, Ole; Beelen, Rob; Wang, Meng; Hoek, Gerard; Andersen, Zorana Jovanovic; Hoffmann, Barbara; Stafoggia, Massimo; Samoli, Evangelia; Weinmayr, Gudrun; Dimakopoulou, Konstantina; Nieuwenhuijsen, Mark; Xun, Wei; Fischer, Paul; Eriksen, Kirsten Thorup; Sørensen, Mette; Tjønneland, Anne; Ricceri, Fulvio; Hoogh, Kees de; Key, Timothy J.; Eeftens, Marloes; Peeters, Petra H.M.; Bueno-de-Mesquita, H. B.; Meliefste, Kees; Oftedal, Bente; Schwarze, Per E.; Nafstad, Per; Galassi, Claudia; Migliore, Enrica; Ranzi, Andrea; Cesaroni, Giulia; Badaloní, Chiara; Forastiére, Francesco; Penell, Johanna; Fairé, Ulf dé; Korek, Michal; Pedersen, Nancy L.; Östenson, Claes Göran; Pershagen, Göran; Fratiglioni, Laura; Concin, Hans; Nagel, Gabriële; Jaensch, Andrea; Ineichen, Alex; Naccarati, Alessio; Katsoulis, Michail; Trichpoulou, A.; Keuken, Menno; Jedyńska, Aleksandra; Kooter, Ingeborg M.; Kukkonen, Jaakko; Brunekreef, Bert; Sokhi, R. S.; Katsouyanni, Klea; Víneis, Paolo

doi:10.1016/j.envint.2015.11.007

Cited by 230 publications

(103 citation statements)

References 28 publications

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“…For the millions of people exposed to PM 2.5 daily, understanding the impact of PM 2.5 on human health is critical for developing interventions aimed at reducing PM 2.5 -related morbidity and mortality globally. Researchers have consistently demonstrated that long-term PM 2.5 exposure is a major contributor to cardiopulmonary disease (Künzli et al, 2005; Giorgini et al, 2015; Martinelli et al, 2013; Zhong et al, 2015; Kloog et al, 2015; Raaschou-Nielsen et al, 2016), and emerging evidence suggests that PM 2.5 is a risk factor for previously unconsidered disease outcomes like cognitive decline (Terzano et al, 2010; Schikowski et al, 2015; Power et al, 2011). Nevertheless, much remains to be understood about how PM 2.5 contributes to even its most well-documented disease outcomes.…”

Section: Introductionmentioning

confidence: 99%

Associations between long-term exposure to PM2.5 component species and blood DNA methylation age in the elderly: The VA normative aging study

Nwanaji‐Enwerem

Dai

Colicino

et al. 2017

Environment International

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Background Long-term PM2.5 exposure and aging have been implicated in multiple shared diseases; studying their relationship is a promising strategy to further understand the adverse impact of PM2.5 on human health. Objective We assessed the relationship of major PM2.5 component species (ammonium, elemental carbon, organic carbon, nitrate, and sulfate) with Horvath and Hannum DNA methylation (DNAm) age, two DNA methylation-based predictors of chronological age. Methods This analysis included 552 participants from the Normative Aging Study with multiple visits between 2000 and 2011 (n = 940 visits). We estimated 1-year PM2.5 species levels at participants’ addresses using the GEOS-chem transport model. Blood DNAm-age was calculated using CpG sites on the Illumina HumanMethylation450 BeadChip. We fit linear mixed-effects models, controlling for PM2.5 mass and lifestyle/environmental factors as fixed effects, with the adaptive LASSO penalty to identify PM2.5 species associated with DNAm-age. Results Sulfate and ammonium were selected by the LASSO in the Horvath DNAm-age models. In a fully-adjusted multiple-species model, interquartile range increases in both 1-year sulfate (95%CI: 0.28, 0.74, P < 0.0001) and ammonium (95%CI: 0.02, 0.70, P = 0.04) levels were associated with at least a 0.36-year increase in Horvath DNAm-age. No PM2.5 species were selected by the LASSO in the Hannum DNAm-age models. Our findings persisted in sensitivity analyses including only visits with 1-year PM2.5 levels within US EPA national ambient air quality standards. Conclusion Our results demonstrate that sulfate and ammonium were most associated with Horvath DNAm-age and suggest that DNAm-age measures differ in their sensitivity to ambient particle exposures and potentially disease.

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Section: Introductionmentioning

confidence: 99%

Associations between long-term exposure to PM2.5 component species and blood DNA methylation age in the elderly: The VA normative aging study

Nwanaji‐Enwerem

Dai

Colicino

et al. 2017

Environment International

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“…In addition to the effects of air pollution on somatic disorders that have been extensively investigated, such as increased risks of pulmonary diseases345, cardiovascular diseases67, or mortality8910, a few studies have focused on the association between ambient air pollution and human psychological health. Exposure to air pollution was found to be related to increased risks of suicide11, and depressive symptoms12.…”

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confidence: 99%

The impacts of air pollution on maternal stress during pregnancy

Lin

Zhou

et al. 2017

Sci Rep

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To investigate the association of air pollution with maternal stress during pregnancy, we enrolled 1,931 women during mid-to-late pregnancy in Shanghai in 2010. The “Life-Event Scale for Pregnant Women” and “Symptom-Checklist-90-Revised Scale” (SCL-90-R) were used to evaluate life event stress and emotional stress, respectively. Air pollution data were collected for each district where pregnant women lived during pregnancy. We associated ambient air pollution with stress scores using multivariable logistic regression models. After adjusting for relevant covariates, an interquartile-range (IQR) increase in sulphur-dioxide (SO2) (OR = 1.30, 95% CI: 1.11–1.52) and particulate-matter with an aerodynamic-diameter <10 μm (PM10) (OR = 1.16, 95% CI: 1.02–1.34) concentrations on the recruitment day, and in the 5-day moving average concentrations of nitrogen-dioxide (NO2) (OR = 1.34, 95% CI: 1.05–1.70) were associated with high Global-Severity-Indices (P75-P100) of the SCL-90-R. These associations were stronger among women bearing high levels (P25-P100) of air pollutants than among women experiencing low levels (P1-P25) of pollutants. The stronger associations and higher levels of pollutants were observed in the cool season than in the warm season. SO2 increases on the recruitment day were also associated with an increased risk of high depression scores (P75-P100). Our findings supported a dose-dependent association between air pollution and emotional stress during pregnancy.

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“…Various lung diseases, such as COPD, asthma, and lung cancer, are related to PM exposure 77–79. COPD is a progressive disease causing abnormal inflammatory response by harmful particles or gas.…”

Section: Respiratory Disease Induced By Particulate Matter Exposurementioning

confidence: 99%

Predictive and Prognostic Biomarkers of Respiratory Diseases due to Particulate Matter Exposure

et al. 2017

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Air pollution is getting severe and concerns about its toxicity effects on airway and lung disease are also increasing. Particulate matter (PM) is major component of air pollutant. It causes respiratory diseases, such as asthma, chronic obstructive pulmonary disease, lung cancer, and so on. PM particles enter the airway and lung by inhalation, causing damages to them. Especially, PM2.5 can penetrate into the alveolus and pass to the systemic circulation. It can affect the cardiopulmonary system and cause cardiopulmonary disorders. In this review, we focused on PM-inducing toxicity mechanisms in the framework of oxidative stress, inflammation, and epigenetic changes. We also reviewed its correlation with respiratory diseases. In addition, we reviewed biomarkers related to PM-induced respiratory diseases. These biomarkers might be used for disease prediction and early diagnosis. With recent trend of using genomic analysis tools in the field of toxicogenomics, respiratory disease biomarkers associated with PM will be continuously investigated. Effective biomarkers derived from earlier studies and further studies might be utilized to reduce respiratory diseases.

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Particulate matter air pollution components and risk for lung cancer

Cited by 230 publications

References 28 publications

Associations between long-term exposure to PM2.5 component species and blood DNA methylation age in the elderly: The VA normative aging study

Associations between long-term exposure to PM2.5 component species and blood DNA methylation age in the elderly: The VA normative aging study

The impacts of air pollution on maternal stress during pregnancy

Predictive and Prognostic Biomarkers of Respiratory Diseases due to Particulate Matter Exposure

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