Particulate Air Pollution Exposure and Plasma Vitamin D Levels in Pregnant Women: A Longitudinal Cohort Study

Zhao, Yan; Wang, Lei; Liu, Hongjiao; Cao, Zhijuan; Su, Xiujuan; Cai, Jing

doi:10.1210/jc.2018-02713

Cited by 26 publications

(22 citation statements)

References 31 publications

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“…Several studies have assessed the effects of air pollution on vitamin D in infants, children, young adults, pregnant women, and the general population [ 9 , 10 , 12 , 18 , 19 , 20 ]. For example, Baïz et al [ 11 ] demonstrated that gestational exposures to ambient urban levels of NO 2 and PM 10 were associated with a decrease in the 25OHD cord blood serum level in 375 mother-child pairs.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, two studies reported positive association between air pollution exposure and vitamin D deficiency in India [ 18 ] and Iran [ 19 ]. In addition, two studies suggested that prenatal exposure to particulate air pollution may play an independent role in maternal vitamin D deficiency [ 9 , 12 ]. Recently, a cross-sectional population-based study in China demonstrated that vitamin D deficiency was related to air pollution [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…Air pollution is a main determinant of the ground level of UVB. Recently, a handful of studies tried to assess the effects of air pollution on serum vitamin D levels, but the findings have been inconclusive [ 9 , 10 , 11 , 12 , 13 ]. The inconsistency might be caused by small sample sizes, and differences in air pollution metrics, geographical conditions, and exposure assessments.…”

Section: Introductionmentioning

confidence: 99%

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Ambient Air Pollutions Are Associated with Vitamin D Status

Yang

Tian

et al. 2021

IJERPH

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Evidence on the effect of ambient air pollution on vitamin D is limited. This study aimed to examine the association of air pollution exposure with serum levels of 25-hydroxyvitamin D (25OHD) using UK Biobank health datasets. A total of 448,337 subjects were included in this analysis. Land Use Regression was applied to assess individual exposures to particulate matter with diameters ≤2.5 µm (PM2.5), ≤10 µm (PM10), nitrogen dioxide (NO2), and nitrogen oxides (NOx). Linear regression models evaluated the associations between air pollutants and serum vitamin D levels after adjustment of a series of confounders. All analyzed air pollutants were negatively associated with serum vitamin 25OHD levels. After adjusting for potential confounders, a 10 μg/m3 increase in concentrations of PM2.5, PM10, NOx, and NO2 was associated with −9.11 (95%CI: −13.25 to −4.97), −2.47 (95%CI: −4.51 to −0.43), −0.56 (95%CI: −0.82 to −0.30), and −1.64 (95%CI: −2.17 to −1.10) nmol/L decrease in serum vitamin 25OHD levels, respectively. Interaction analyses suggested that the effects of air pollution were more pronounced in females. In conclusion, long-term exposures to ambient PM2.5, PM10, NOx, and NO2 were associated with vitamin D status in a large UK cohort.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ambient Air Pollutions Are Associated with Vitamin D Status

Yang

Tian

et al. 2021

IJERPH

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“…29 Furthermore, previous studies have suggested that prenatal particulate matter exposure is associated with prenatal vitamin D deficiency. Prenatal exposure to PM 2.5 and PM 10 is associated with decreased maternal plasma and CB vitamin D. 14,15 Furthermore, vitamin D deficiency makes children with asthma more susceptible to the adverse effects of air pollution exposure. 19,20 However, the modifying effect of vitamin D level on PM 2.5 einduced AD had not previously been evaluated.…”

Section: Discussionmentioning

confidence: 99%

“…Particulate matter exposure during pregnancy is associated with maternal vitamin D deficiency and lower cord blood (CB) vitamin D levels. 14,15 Because vitamin D suppresses air pollutanteinduced inflammation and oxidative stress, [16][17][18] vitamin D deficiency increases the adverse effects of air pollutant exposure. 19,20 The association between prenatal PM 2.5 exposure and vitamin D deficiency in relation to AD in an offspring is unknown.…”

Section: Introductionmentioning

confidence: 99%

Prenatal PM2.5 exposure and vitamin D–associated early persistent atopic dermatitis via placental methylation

Yang

Lee

et al. 2020

Annals of Allergy, Asthma & Immunology

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Background: The effects of prenatal particulate matter with an aerodynamic diameter ranging from 0.1 mm to 2.5 mm (PM 2.5 ) and vitamin D on atopic dermatitis (AD) phenotypes have not been evaluated. DNA methylation and cord blood (CB) vitamin D could represent a plausible link between prenatal PM 2.5 exposure and AD in an offspring. Objective: To determine the critical windows of prenatal PM 2.5 exposure on the AD phenotypes, if vitamin D modulated these effects, and if placental DNA methylation mediated these effects on AD in offspring. Methods: Motherechild pairs were enrolled from the birth cohort of the Cohort for Childhood Origin of Asthma and allergic diseases (COCOA) study. PM 2.5 was estimated by land-use regression models, and CB vitamin D was measured by chemiluminescence immunoassay.

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Investigating the association between vitamin D dietary intake during pregnancy and incidence of clubfoot in neonates

Idriss,

Werler

2023

Birth Defects Research

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AimsTalipes equinovarus (clubfoot) is a congenital lower foot deformity that results from a neuromuscular deficiency, but the precise etiology remains elusive. Vitamin D is important for fetal neuromuscular development. In this study, we investigated the association between dietary vitamin D intake during pregnancy and incidence of clubfoot in neonates, since such a question has thus far been overlooked.MethodsWe conducted a secondary analysis of data collected in the United States, between 2007 and 2011 for a case–control study of children born with clubfoot. Participating mothers were interviewed by telephone about dietary and other health and life‐style indicators. Exposure to vitamin D was recorded as the average daily intake of dietary vitamin D over a period of 6 months before pregnancy began. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression.ResultsThe dataset included 2667 study participants, of which 663 were cases. Logistic regression showed no significant association between dietary vitamin D or log10(Vitamin D) intake during pregnancy and incidence of clubfoot in neonates (OR = 1.00, CI = 1.00–1.00, OR = 1.51, CI = 0.83–2.82, respectively). No interaction in the regression model was found between vitamin D and other predictor variables. Results were not confounded by supplement intake of vitamin D during pregnancy.ConclusionsResults show no evidence of an association between dietary vitamin D intake and incidence of clubfoot in neonates. The lack of association is not confounded by consumption of vitamin D supplements during pregnancy.

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Particulate Air Pollution Exposure and Plasma Vitamin D Levels in Pregnant Women: A Longitudinal Cohort Study

Cited by 26 publications

References 31 publications

Ambient Air Pollutions Are Associated with Vitamin D Status

Ambient Air Pollutions Are Associated with Vitamin D Status

Prenatal PM2.5 exposure and vitamin D–associated early persistent atopic dermatitis via placental methylation

Investigating the association between vitamin D dietary intake during pregnancy and incidence of clubfoot in neonates

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