Particularités anesthésiques de la neurochirurgie stéréotaxique

Debailleul, A.M; Börtlein, M.L.; Touzet, Gustavo; Krivosic-Horber, R

doi:10.1016/s0750-7658(01)00504-4

Cited by 5 publications

(1 citation statement)

References 55 publications

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“…These include awake craniotomies (Berkenstadt et al 2001;Johnson and Egan 1998;Sarang and Dinsmore 2003;Manninen et al 2006), stereotaxic neurosurgery (Debailleul et al 2002), epilepsy surgery (Herrick et al 2002;Wass et al 2001) and magnetic resonance-guided neurosurgery (Berkenstadt et al 2001). …”

Section: Neuranaesthesiamentioning

confidence: 99%

Remifentanil and Other Opioids

Servin

Billard

Handbook of Experimental Pharmacology

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Most opioids used in anaesthesia are of the anilidopiperidine family, including fentanyl, alfentanil, sufentanil and remifentanil. While all share similar pharmacological properties, remifentanil, the newest one, is probably the most original, which is the reason this review focusses especially on this drug. Remifentanil is a potent mu-agonist that retains all the pharmacodynamic characteristics of its class (regarding analgesia, respiratory depression, muscle rigidity, nausea and vomiting, pruritus, etc.) but with a unique pharmacokinetic profile that combines a short onset and the fastest offset, independent of the infusion duration. Consequently, it offers a unique titratability when its effects need to be quickly achieved or suppressed, but it requires specific drug delivery schemes such as continuous infusion, target-controlled infusion and anticipated postoperative pain treatment. Kinetic differences between opioids used in anaesthesia and some clinical uses of remifentanil are reviewed in this chapter.

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