Le propofol et l'AIVOC en neuro-anesthésie

Debailleul, A.M; Fichten, A.; Krivosic-Horber, R

doi:10.1016/j.annfar.2004.02.038

Cited by 8 publications

(2 citation statements)

References 59 publications

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“…Signal was recorded by a MICROMED system with frequency sampling of 256 Hz. SEEG was performed under general anaesthesia using Target-Controlled Infusion (TCI) with propofol (2,6 diisopropylphénol) 65 . Deepness of anaesthesia was controlled by measuring the Bispectral-Index (BIS) 66 .…”

Section: Methodsmentioning

confidence: 99%

Brain-scale cortico-cortical functional connectivity in the delta-theta band is a robust signature of conscious states: an intracranial and scalp EEG study

Bourdillon

Hermann

Guénot

et al. 2020

Sci Rep

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Long-range cortico-cortical functional connectivity has long been theorized to be necessary for conscious states. In the present work, we estimate long-range cortical connectivity in a series of intracranial and scalp EEG recordings experiments. In the two first experiments intracranial-EEG (iEEG) was recorded during four distinct states within the same individuals: conscious wakefulness (CW), rapid-eye-movement sleep (REM), stable periods of slow-wave sleep (SWS) and deep propofol anaesthesia (PA). We estimated functional connectivity using the following two methods: weighted Symbolic-Mutual-Information (wSMI) and phase-locked value (PLV). Our results showed that longrange functional connectivity in the delta-theta frequency band specifically discriminated CW and REM from SWS and PA. In the third experiment, we generalized this original finding on a large cohort of brain-injured patients. FC in the delta-theta band was significantly higher in patients being in a minimally conscious state (MCS) than in those being in a vegetative state (or unresponsive wakefulness syndrome). Taken together the present results suggest that FC of cortical activity in this slow frequency band is a new and robust signature of conscious states. Identifying a robust neural signature of conscious states constitutes a major scientific and medical challenge. While several theoretical and empirical works put forward the importance of cortico-cortical connectivity for conscious states 1-5 , this property remains highly debated regarding: (i) the long-range 6 versus short-range type of functional connectivity (FC) 7 (ii) the relevant frequencies involved in this cortico-cortical connectivity, with contradicting proposals ranging from ultra-slow (< 0.01 Hz) 8 , to slow (0.5-4 Hz) 9,10 , or even faster theta, alpha and gamma-band rhythms 11 , and (iii) the general value of this property when comparing various conscious and unconscious states. In order to address these important and unsolved questions we first specified a clear definition of what we consider as a conscious state: a state during which experiences can be self-reported and memorized in episodic memory 12. In that perspective, dreams that can be recalled as subjective self-reports belong to the class of conscious experiences. Given that most vivid and memorized dreams occur during REM-sleep or during transitions from SWS to REM-sleep 13-15 , this stage can be defined as a state that includes conscious episodes. Then, we explored cortico-cortical connectivity on direct intracranial EEG (iEEG) recordings performed in the same subjects across various conscious and unconscious states. Specifically, we recorded iEEG in 12 drug-resistant

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Section: Methodsmentioning

confidence: 99%

Brain-scale cortico-cortical functional connectivity in the delta-theta band is a robust signature of conscious states: an intracranial and scalp EEG study

Bourdillon

Hermann

Guénot

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…SEEG was performed under general anaesthesia using Target-Controlled Infusion (TCI) with propofol (2,6 diisopropylphénol) (Debailleul et al, 2004). Deepness of anaesthesia was controlled by measuring the Bispectral-Index (BIS) (Hans et al, 2000).…”

Section: Methodsmentioning

confidence: 99%

Slow cortico-cortical connectivity (2-5Hz) is a new robust signature of conscious states

Bourdillon

Hermann

Guénot

et al. 2019

Preprint

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32While long-range cortico-cortical functional connectivity has been reported by several studies 33 as a necessary condition of conscious state, precise empirical evidence is still scarce. In the 34 present work we provide such a direct and conclusive evidence in a set of three experiments. 35 In the two first experiments intracranial-EEG was recorded during four distinct states in the 36 same individuals: conscious wakefulness (CW), rapid-eye-movement sleep (REM), stable 37 periods of slow-wave sleep (SWS) and deep propofol anaesthesia (PA). We discovered that 38 long-range FC, computed by the weighted Symbolic-Mutual-Information (wSMI) in the 2-39 5Hz frequency band was a specific marker of conscious states that could discriminate CW and 40 REM from SWS and PA. In the third experiment, we generalized this original finding on a 41 large cohort of brain-injured patients by revealing that wSMI in the 2-5 Hz range was also 42 able to accurately discriminate patients in the vegetative state (or unresponsive wakefulness 43 syndrome) from patients in the minimally conscious state. Taken together the present results 44 suggest that 2-5Hz FC is a new and robust signature of conscious states. 45 46 50 Crone et al., 2014; Dehaene and Changeux, 2011; Dehaene and Naccache, 2001), this 51 property remains highly debated regarding : (i) the long-range (Laureys and Schiff, 2012) 52 versus short-range type of functional connectivity (Lamme, 2006) (ii) the relevant frequencies 53 involved in this cortico-cortical connectivity, with contradicting proposals ranging from ultra-54 slow (<0.01Hz) (Barttfeld et al., 2015), to slow (0.5-4Hz) (He et al., 2008; He and Raichle, 55 2009), or even faster theta, alpha and gamma-band rhythms (Schiff et al., 2014), and (iii) the 56 general value of this property when comparing various conscious and unconscious states.57In order to address these important and unsolved questions, we explored cortico-cortical 58 connectivity on direct intracranial EEG (iEEG) recordings performed in the same subjects 59 across various conscious and unconscious states. More precisely, we recorded iEEG in 12 60 drug-resistant epileptic patients undergoing a stereoelectroencephalography (SEEG) for pre-61 surgical evaluation with large and brain-scale implantations. Each patient was recorded in two 62 3 states that are associated with conscious experience (conscious wakefulness (CW) and rapid-63 eye movement sleep (REM) that is typically associated with conscious dreaming), as well as 64 in two unconscious states: very stable periods of slow-wave sleep (SWS) that are usually free 65 of conscious dreaming (Siclari et al., 2017), and deep propofol anaesthesia (PA). 66 We estimated cortico-cortical connectivity by computing the weighted symbolic mutual 67 information (wSMI) in various frequency bands. We previously conceived wSMI and used 68 this measure to distinguish conscious and minimally conscious (MCS) patients from 69 vegetative state/unresponsive wakefulness syndrome (VS/UWS) patients (King et al., 2013). 7...

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The KEEP SIMPLEST Study: Improving In-House Delays and Periinterventional Management in Stroke Thrombectomy—A Matched Pair Analysis

et al. 2019

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Le propofol et l'AIVOC en neuro-anesthésie

Cited by 8 publications

References 59 publications

Brain-scale cortico-cortical functional connectivity in the delta-theta band is a robust signature of conscious states: an intracranial and scalp EEG study

Brain-scale cortico-cortical functional connectivity in the delta-theta band is a robust signature of conscious states: an intracranial and scalp EEG study

Slow cortico-cortical connectivity (2-5Hz) is a new robust signature of conscious states

The KEEP SIMPLEST Study: Improving In-House Delays and Periinterventional Management in Stroke Thrombectomy—A Matched Pair Analysis

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