Particles Containing Cells as a Strategy to Promote Remyelination in Patients With Multiple Sclerosis

Matías‐Guiu, Jorge; Montero‐Escribano, Paloma; Barcia, Juan A.; Canales-Aguirre, Alejandro A.; Mateos-Díaz, Juan Carlos

doi:10.3389/fneur.2020.00638

Cited by 11 publications

(11 citation statements)

References 108 publications

(132 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thirdly, drugs favoring migration and potential subsequent differentiation of OPCs in multiple sclerosis represent a new line of treatment to promote remyelination; however, this type of treatment, although effective, would not be so in NMOSD in this context. To achieve remyelination, cell therapy with OPCs [ 51 ], which may protect against AQP4–IgG, seems to be the most probable target in the search for a restorative therapy for NMOSD. At this point, a potential synergy between cell therapy and bioengineering may involve the use of biomaterials with biomedical applications in the central nervous system, such as chitosan [ 52 ], which may condition OPCs to avoid the effects of AQP4–IgG and, thus, reach target sites to promote remyelination; this may represent a promising alternative.…”

Section: Discussionmentioning

confidence: 99%

Sera from Patients with NMOSD Reduce the Differentiation Capacity of Precursor Cells in the Central Nervous System

Gómez‐Pinedo¹,

García-Ávila²,

Gallego-Villarejo³

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

Introduction: AQP4 (aquaporin-4)–immunoglobulin G (IgG)-mediated neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease that affects the central nervous system, particularly the spinal cord and optic nerve; remyelination capacity in neuromyelitis optica is yet to be determined, as is the role of AQP4–IgG in cell differentiation. Material and Methods: We included three groups—a group of patients with AQP4–IgG-positive neuromyelitis optica, a healthy group, and a sham group. We analyzed differentiation capacity in cultures of neurospheres from the subventricular zone of mice by adding serum at two different times: early and advanced stages of differentiation. We also analyzed differentiation into different cell lines. Results and Conclusions: The effect of sera from patients with NMOSD on precursor cells differs according to the degree of differentiation, and probably affects oligodendrocyte progenitor cells from NG2 cells to a lesser extent than cells from the subventricular zone; however, the resulting oligodendrocytes may be compromised in terms of maturation and possibly limited in their ability to generate myelin. Furthermore, these cells decrease in number with age. It is very unlikely that the use of drugs favoring the migration and differentiation of oligodendrocyte progenitor cells in multiple sclerosis would be effective in the context of neuromyelitis optica, but cell therapy with oligodendrocyte progenitor cells seems to be a potential alternative.

show abstract

Section: Discussionmentioning

confidence: 99%

Sera from Patients with NMOSD Reduce the Differentiation Capacity of Precursor Cells in the Central Nervous System

Gómez‐Pinedo¹,

García-Ávila²,

Gallego-Villarejo³

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…Chitosan, being an abundant and cheap natural polymer, appeared to be an interesting material for regenerative medicine, in particular for nerve tissue engineering [ 36 , 37 , 38 , 39 ]. Here, chitosan solvent casting was able to replicate and retain the micro-pattern features in all of the three geometries (GR, ISO, SCA), with an optimal resolution at the micrometer level.…”

Section: Discussionmentioning

confidence: 99%

Chitosan Micro-Grooved Membranes with Increased Asymmetry for the Improvement of the Schwann Cell Response in Nerve Regeneration

Scaccini

Mezzena

Masi

et al. 2021

IJMS

View full text Add to dashboard Cite

Peripheral nerve injuries are a common condition in which a nerve is damaged, affecting more than one million people every year. There are still no efficient therapeutic treatments for these injuries. Artificial scaffolds can offer new opportunities for nerve regeneration applications; in this framework, chitosan is emerging as a promising biomaterial. Here, we set up a simple and effective method for the production of micro-structured chitosan films by solvent casting, with high fidelity in the micro-pattern reproducibility. Three types of chitosan directional micro-grooved patterns, presenting different levels of symmetricity, were developed for application in nerve regenerative medicine: gratings (GR), isosceles triangles (ISO) and scalene triangles (SCA). The directional patterns were tested with a Schwann cell line. The most asymmetric topography (SCA), although it polarized the cell shaping less efficiently, promoted higher cell proliferation and a faster cell migration, both individually and collectively, with a higher directional persistence of motion. Overall, the use of micro-structured asymmetrical directional topographies may be exploited to enhance the nerve regeneration process mediated by chitosan scaffolds.

show abstract

“…A recent study with human oligodendroglioma cells showed that the intranasal route is viable for administering cells, paving the way for a promising new scenario for cell therapies for MS [43,44].…”

Section: Oligodendrocyte Precursor Cellsmentioning

confidence: 99%

The Integration of Cell Therapy and Biomaterials as Treatment Strategies for Remyelination

López-Muguruza

Villar-Gómez

Matías‐Guiu

et al. 2022

Life

Self Cite

View full text Add to dashboard Cite

Multiple sclerosis (MS) is a chronic degenerative autoimmune disease of the central nervous system that causes inflammation, demyelinating lesions, and axonal damage and is associated with a high rate of early-onset disability. Disease-modifying therapies are used to mitigate the inflammatory process in MS but do not promote regeneration or remyelination; cell therapy may play an important role in these processes, modulating inflammation and promoting the repopulation of oligodendrocytes, which are responsible for myelin repair. The development of genetic engineering has led to the emergence of stable, biocompatible biomaterials that may promote a favorable environment for exogenous cells. This review summarizes the available evidence about the effects of transplantation of different types of stem cells reported in studies with several animal models of MS and clinical trials in human patients. We also address the advantages of combining cell therapy with biomaterials.

show abstract

Particles Containing Cells as a Strategy to Promote Remyelination in Patients With Multiple Sclerosis

Cited by 11 publications

References 108 publications

Sera from Patients with NMOSD Reduce the Differentiation Capacity of Precursor Cells in the Central Nervous System

Sera from Patients with NMOSD Reduce the Differentiation Capacity of Precursor Cells in the Central Nervous System

Chitosan Micro-Grooved Membranes with Increased Asymmetry for the Improvement of the Schwann Cell Response in Nerve Regeneration

The Integration of Cell Therapy and Biomaterials as Treatment Strategies for Remyelination

Contact Info

Product

Resources

About