Particles Causing Lung Disease

Kilburn, Kaye H.

doi:10.2307/3429695

Cited by 7 publications

(1 citation statement)

References 48 publications

(52 reference statements)

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“…Such observations suggest the possibility free particles may exit the hilar lymph nodes in efferent lymph fluid and enter the blood for transport elsewhere. An expected outcome of this process vould be the redistribution of particles to other body sites (267). The appearance ofparticle-containing macrophage as well as free particles in various body organs lends support to this possibility (48,(268)(269)(270).…”

Section: Tracheobronchial Lymph Node Macrophagesmentioning

confidence: 82%

Pulmonary and thoracic macrophage subpopulations and clearance of particles from the lung.

Lehnert

1992

Environ Health Perspect

151

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Pulmonary macrophages consist of several subpopulations that can be defined by their anatomial locations as well as by other criteria. In addition to,the well-known alveolar macrophages that reside on the alveolar surface, pulmonary macrophages also occur in the conductingairways, in various pulmonar interstitial regions, and, in some mammalian species, in the lung's intravacular compartment. Other thoracic macrophages of relevance to puhnonary defense and some lung disem processesare the pleiural macrophages resident in the pleural space and macrophages present in regional lymph nodes that receive lymphatic drainge from the lung. Of the above subpopulations of pulmonar and thoracic macrophages, the alveolar macrophages have received the most experimental attention in the context ofthe pulmonary clearance and retenton of d particls. Accordingly, less infmationis currently alable rardig the roles other pulmonary and thoracic populations of a g may play inthe removalof partcles from the lower rsprtor tract and associatedtissue compartments. This report provides an overview ofthe various subpopulations of pulmonary and thoracic macrophages, as defined by their anaial locations. The known and postulated roles ofmacrophages in the pulmonary clearnce and retention of particles are reviewed, with particular emphasis on macrophage-associated processes involved in the pulmonary clearance of relatively insoluble particles.

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Section: Tracheobronchial Lymph Node Macrophagesmentioning

confidence: 82%

Pulmonary and thoracic macrophage subpopulations and clearance of particles from the lung.

Lehnert

1992

Environ Health Perspect

151

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Deposition of lead and cadmium released by cigarette smoke in dental structures and resin composite

Takeuchi

Correa-Afonso

Pedrazzi

et al. 2011

Microscopy Res & Technique

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Cigarette smoke is a significant source of cadmium, lead, and toxic elements, which are absorbed into the human organism. In this context, the aim of this study was to investigate in vitro the presence of toxic elements, cadmium, and lead deriving from cigarette smoke in the resin composite, dentine, and dental enamel. Eight cylindrical specimens were fabricated from resin composite, bovine enamel, and root dentin fragments that were wet ground and polished with abrasive paper to obtain sections with 6-mm diameter and 2-mm thickness. All specimens were exposed to the smoke of 10 cigarettes/day during 8 days. After the simulation of the cigarette smoke, the specimens were examined with scanning electron microscopy (SEM) and the energy-dispersive X-ray analysis. In the photomicrographic analysis in SEM, no morphological alterations were found; however, the microanalysis identified the presence of cadmium, arsenic, and lead in the different specimens. These findings suggest that the deposition of these elements derived from cigarette smoke could be favored by dental structures and resin composite.

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Neutrophil Influx Measured in Nasal Lavages of Humans Exposed to Ozone

Graham

Henderson

House

1988

Archives of Environmental Health: An International Journal

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Neutrophils (PMNs) obtained by nasal lavage were counted to determine if ozone, an oxidant air pollutant, induces an acute inflammatory response in the upper respiratory tract (URT) of humans. Background data were obtained by the nasal lavages from 200 nonexperimentally exposed subjects. Then, using a known inflammatory agent for the URT, rhinovirus-type 39, the induction, peak, and resolution of an acute inflammatory response was shown to be documented by the nasal lavage PMN counts. To determined if ozone induces this response, 41 subjects were exposed to either filtered air or 0.5 ppm ozone for 4 hr, on 2 consecutive days. Nasal lavages were taken pre-, immediately post each exposure, and 22 hr following the last exposure. Lavage PMN counts increased significantly (p = .005) in the ozone-exposed group, with 3.5-, 6.5-, and 3.9-fold increases over the air-exposed group at the post 1, pre 2, and post 2 time points, respectively. Ozone induces an inflammatory response in the URT of humans, and nasal lavage PMN counts are useful to assay the inflammatory properties of air pollutants.

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Particles Causing Lung Disease

Cited by 7 publications

References 48 publications

Pulmonary and thoracic macrophage subpopulations and clearance of particles from the lung.

Pulmonary and thoracic macrophage subpopulations and clearance of particles from the lung.

Deposition of lead and cadmium released by cigarette smoke in dental structures and resin composite

Neutrophil Influx Measured in Nasal Lavages of Humans Exposed to Ozone

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