Particle Therapy for Breast Cancer: Benefits and Challenges

Luo, Wanrong; Ali, Yasser; Liu, Chong; Wang, Yuchen; Liu, Caorui; Jin, Xiaoni; Zhou, Guangming; Liu, Ning-Ang

doi:10.3389/fonc.2021.662826

Cited by 8 publications

(7 citation statements)

References 61 publications

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“…Suboptimal patient selection is a potential factor. The majority of early breast cancer patients who receive particle therapy as radical treatment are at low risk of recurrence or cannot tolerate surgery because of physical reasons such as cardiopulmonary failure ( 72 ). Further, technical challenges of particle therapy also remain concern.…”

Section: Discussionmentioning

confidence: 99%

Particle radiotherapy for breast cancer

Ruan,

Okamoto,

Ohno

et al. 2023

Front. Oncol.

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Breast cancer is the most common malignant tumor in female patients. Along with surgery, radiotherapy is one of the most commonly prescribed treatments for breast cancer. Over the past few decades, breast cancer radiotherapy technology has significantly improved. Nevertheless, related posttherapy complications should not be overlooked. Common complications include dose-related coronary toxicity, radiation pneumonia, and the risk of second primary cancer of the contralateral breast. Particle radiotherapy with protons or carbon ions is widely attracting interest as a potential competitor to conventional photon radiotherapy because of its superior physical and biological characteristics. This article summarizes the results of clinical research on proton and carbon-ion radiotherapy for treating breast cancer

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Section: Discussionmentioning

confidence: 99%

Particle radiotherapy for breast cancer

Ruan,

Okamoto,

Ohno

et al. 2023

Front. Oncol.

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“…The dose deposition of carbon ion beam is low in the entrance area of normal tissue exposure, but greatly enhanced at the end of tumor range, and then suddenly decreased to close to zero, which can achieve “targeted explosion” of tumor. Dosimetric comparative analyses have identified the advantages of proton and carbon ion therapy for better heart protection with radiotherapy to chest wall ± breast target ( 13 , 14 ).…”

Section: Comparison Of the Effects Of Different Radiotherapy Techniqu...mentioning

confidence: 99%

Recent advances progress in radiotherapy for breast cancer after breast-conserving surgery: a review

Wang,

Shen,

et al. 2023

Front. Oncol.

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Adjuvant radiotherapy after breast-conserving surgery has become an integral part of the treatment of breast cancer. In recent years, the development of radiotherapy technology has made great progress in this field, including the comparison of the curative effects of various radiotherapy techniques and the performance of the segmentation times. The choice of radiotherapy technology needs to be co-determined by clinical evidence practice and evaluated for each individual patient to achieve precision radiotherapy. This article discusses the treatment effects of different radiotherapy, techniques, the risk of second cancers and short-range radiation therapy techniques after breast-conserving surgery such as hypo fractionated whole breast irradiation and accelerated partial breast irradiation. The choice of radiotherapy regimen needs to be based on the individual condition of the patient, and the general principle is to focus on the target area and reduce the irradiation of the normal tissues and organs. Short-range radiotherapy and hypofractionated are superior to conventional radiotherapy and are expected to become the mainstream treatment after breast-conserving surgery.

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“…However, the associated challenge with surgery in breast cancer therapy involves macromolecular peripheral oxidative damage during the postoperative period [ 12 ]. Similarly, radiations are used in breast cancer treatment followed by surgery; however, it poses the challenge of resistance and in patients with 5-year age has shown higher chances of relapse [ 55 ]. To cope with the radiation challenge, a recent study is aimed at evaluating the clinical efficacy and side effects of intraoperative radiotherapy after neoadjuvant chemotherapy.…”

Section: Challenges In Breast Cancer Treatmentmentioning

confidence: 99%

Flavonoids Targeting the mTOR Signaling Cascades in Cancer: A Potential Crosstalk in Anti-Breast Cancer Therapy

Hussain

Khan

Alam

et al. 2022

Oxidative Medicine and Cellular Longevity

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Cancer is one of the leading causes of death worldwide. Breast cancer is the second leading cause of death in women, with triple-negative breast cancer being the most lethal and aggressive form. Conventional therapies, such as radiation, surgery, hormonal, immune, gene, and chemotherapy, are widely used, but their therapeutic efficacy is limited due to adverse side effects, toxicities, resistance, recurrence, and therapeutic failure. Many molecules have been identified and investigated as potential therapeutic agents for breast cancer, with a focus on various signaling pathways. Flavonoids are a versatile class of phytochemicals that have been used in cancer treatment to overcome issues with traditional therapies. Cell proliferation, growth, apoptosis, autophagy, and survival are all controlled by mammalian target of rapamycin (mTOR) signaling. Flavonoids target mTOR signaling in breast cancer, and when this signaling pathway is regulated or deregulated, various signaling pathways provide potential therapeutic means. The role of various flavonoids as phytochemicals in targeting mTOR signaling pathways in breast cancer is highlighted in this review.

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Particle Therapy for Breast Cancer: Benefits and Challenges

Cited by 8 publications

References 61 publications

Particle radiotherapy for breast cancer

Particle radiotherapy for breast cancer

Recent advances progress in radiotherapy for breast cancer after breast-conserving surgery: a review

Flavonoids Targeting the mTOR Signaling Cascades in Cancer: A Potential Crosstalk in Anti-Breast Cancer Therapy

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