Particle size effect of curcumin nanosuspensions on cytotoxicity, cellular internalization, in vivo pharmacokinetics and biodistribution

Effects of curcumin nanoformulations on cellular function in Niemann-Pick disease type C astrocytes

“…Our project focused on a range of lipidated curcumin nanoformulations (Table 1) which are used for increasing the bioavailability of curcumin which is otherwise poorly absorbed through the intestines 15 . Formulation of curcumin into a lipid vector allows for improved delivery across the blood-gut barrier, the achievement of higher concentrations of curcumin in the blood and tissues, and reduced renal clearance, all of which is essential for treating disease 19 . Recent evidence has shown that formulation into nanoparticles allows for even greater penetration into the blood and higher steady state levels, dependent on particle size 19 .…”

“…Formulation of curcumin into a lipid vector allows for improved delivery across the blood-gut barrier, the achievement of higher concentrations of curcumin in the blood and tissues, and reduced renal clearance, all of which is essential for treating disease 19 . Recent evidence has shown that formulation into nanoparticles allows for even greater penetration into the blood and higher steady state levels, dependent on particle size 19 . Our study is the first to demonstrate that all of these formulated lipidated curcumin particles are nanoparticles, ranging in size from 50-250nm.…”

“…Furthermore, a recent study has highlighted that different sized curcumin nanosupensions/nanoformulations occupy tissues at varying concentrations dependent on their particle size. For example, with initial plasma concentrations of around 5µM following an intravenous injection the highest concentration in the liver were observed with 200nm curcumin particles at 10 min post injection whereas in the brain the highest concentration was observed with 70nm particles at 20-30mins post injection 19 . These studies indicate that higher therapeutic concentrations of curcumin can be achieved using nanosuspensions and that tissue penetrance may be dependent on particle size.…”

Molecular insight into the therapeutic potential of phytoconstituents targeting protein conformation and their expression

“…Curcuma domestica contains active compound curcumin that is widely known as an anti-inflammatory (Bi et al, 2016;Zhao et al, 2016), anticancer (Gu et al, 2016;Sufi et al, 2016;Tong et al, 2016) and recently antimicrobial agent (Rahayu et al, 2013;Tyagi et al, 2015). Curcumin correlates with its ability to bind to the vitamin D receptor (VDR) as a potential ligand.…”

Curcumin nanoparticles potentiate therapeutic effectiveness of acitrein in moderate-to-severe psoriasis patients and control serum cholesterol levels

“…[10] Over the last decade, various carrier-free nanoparticles have been designed to overcome the physicochemical properties exhibited by curcumin. Nevertheless, to the best of our knowledge, most studies have remained at experimental in vitro research, only a few are concerning in vivo studies in rats and mice, [11][12][13][14][15][16][17][18] lacking the clinical application.…”