Effects of curcumin nanoformulations on cellular function in Niemann-Pick disease type C astrocytes

Maguire, Emily; Lj, Haslett; Jl, Welton; Waller-Evans, Helen; Goike, Jule; Eh, Clark; Hr, Knifton; R, Shrestha; Wager, Kim; Webb, Richard; Lloyd-Evans, Emyr

doi:10.1101/135830

Cited by 1 publication

(2 citation statements)

References 32 publications

(63 reference statements)

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“…The nanoformulation of curcumin can be a promising agent against Niemann-Pick disease type C astrocytes [120]. Curcumin has been reported to have several medicinal properties, wherein it was observed that nanoformulations of curcumin were able to increase cytosolic calcium ion levels and cell viability in astrocytes [120]. Another compound δ-tocopherol was found to decreased cholesterol levels and also lipid accumulation, it also reduced lysosomal enlargement.…”

Section: Frontotemporal Dementia (Ftd)mentioning

confidence: 99%

“…Extracts of Piper nigrum (fruit) and Curcuma longa (rhizome) also inhibited the AChE significantly which is considered one of the key targets for therapeutic strategies against dementia [119]. The nanoformulation of curcumin can be a promising agent against Niemann-Pick disease type C astrocytes [120]. Curcumin has been reported to have several medicinal properties, wherein it was observed that nanoformulations of curcumin were able to increase cytosolic calcium ion levels and cell viability in astrocytes [120].…”

Section: Frontotemporal Dementia (Ftd)mentioning

confidence: 99%

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Neuroprotection: Targeting Multiple Pathways by Naturally Occurring Phytochemicals

et al. 2020

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With the increase in the expectancy of the life span of humans, neurodegenerative diseases (NDs) have imposed a considerable burden on the family, society, and nation. In defiance of the breakthroughs in the knowledge of the pathogenesis and underlying mechanisms of various NDs, very little success has been achieved in developing effective therapies. This review draws a bead on the availability of the nutraceuticals to date for various NDs (Alzheimer’s disease, Parkinson’s disease, Amyotrophic lateral sclerosis, Huntington’s disease, vascular cognitive impairment, Prion disease, Spinocerebellar ataxia, Spinal muscular atrophy, Frontotemporal dementia, and Pick’s disease) focusing on their various mechanisms of action in various in vivo and in vitro models of NDs. This review is distinctive in its compilation to critically review preclinical and clinical studies of the maximum phytochemicals in amelioration and prevention of almost all kinds of neurodegenerative diseases and address their possible mechanism of action. PubMed, Embase, and Cochrane Library searches were used for preclinical studies, while ClinicalTrials.gov and PubMed were searched for clinical updates. The results from preclinical studies demonstrate the efficacious effects of the phytochemicals in various NDs while clinical reports showing mixed results with promise for phytochemical use as an adjunct to the conventional treatment in various NDs. These studies together suggest that phytochemicals can significantly act upon different mechanisms of disease such as oxidative stress, inflammation, apoptotic pathways, and gene regulation. However, further clinical studies are needed that should include the appropriate biomarkers of NDs and the effect of phytochemicals on them as well as targeting the appropriate population.

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Section: Frontotemporal Dementia (Ftd)mentioning

confidence: 99%

Section: Frontotemporal Dementia (Ftd)mentioning

confidence: 99%

Neuroprotection: Targeting Multiple Pathways by Naturally Occurring Phytochemicals

et al. 2020

View full text Add to dashboard Cite

show abstract

Effects of curcumin nanoformulations on cellular function in Niemann-Pick disease type C astrocytes

Abstract: Niemann-Pick disease type C1 (NPC disease) is a neurodegenerative multi-lipid lysosomal storage disease caused by mutations in the NPC1 gene presenting with reduced lysosomal

Cited by 1 publication

References 32 publications

Neuroprotection: Targeting Multiple Pathways by Naturally Occurring Phytochemicals

Neuroprotection: Targeting Multiple Pathways by Naturally Occurring Phytochemicals

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