Particle-based immunochemical separation of methicillin resistant Staphylococcus aureus with indirect electrochemical detection of labeling oligonucleotides

Číhalová, Kristýna; Hegerova, Dagmar; Dostálová, Simona; Jelínková, Pavlína; Krejčová, Ludmila; Milosavljević, Vedran; Křížková, Soňa; Kopel, Pavel; Adam, Vojtěch

doi:10.1039/c6ay01296e

Cited by 13 publications

(4 citation statements)

References 32 publications

(38 reference statements)

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“…A liposome-based nanodevice used magnetic particles as carriers for DNA and drugs [ 13 ]. Paramagnetic nano- and microparticles were used for diagnostic detection of cancer biomarkers [ 14 , 15 , 16 , 17 ], viruses [ 18 , 19 ], and bacteria [ 20 , 21 ].…”

Section: Magnetic Nanoparticles Designmentioning

confidence: 99%

Magnetic Nanoparticles: From Design and Synthesis to Real World Applications

et al. 2017

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The increasing number of scientific publications focusing on magnetic materials indicates growing interest in the broader scientific community. Substantial progress was made in the synthesis of magnetic materials of desired size, morphology, chemical composition, and surface chemistry. Physical and chemical stability of magnetic materials is acquired by the coating. Moreover, surface layers of polymers, silica, biomolecules, etc. can be designed to obtain affinity to target molecules. The combination of the ability to respond to the external magnetic field and the rich possibilities of coatings makes magnetic materials universal tool for magnetic separations of small molecules, biomolecules and cells. In the biomedical field, magnetic particles and magnetic composites are utilized as the drug carriers, as contrast agents for magnetic resonance imaging (MRI), and in magnetic hyperthermia. However, the multifunctional magnetic particles enabling the diagnosis and therapy at the same time are emerging. The presented review article summarizes the findings regarding the design and synthesis of magnetic materials focused on biomedical applications. We highlight the utilization of magnetic materials in separation/preconcentration of various molecules and cells, and their use in diagnosis and therapy.

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Section: Magnetic Nanoparticles Designmentioning

confidence: 99%

Magnetic Nanoparticles: From Design and Synthesis to Real World Applications

et al. 2017

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“…Hence their physical and chemical properties equally contribute to determine their functionality in biomedical science. [118][119][120][121][122][123][124][125][126][127][128][129]. For instance, physical parameters include magnetic behavior, particle size and optimized relationship between the substrate and reacting medium are very essential.…”

Section: General Parameters For Designing Mnpsmentioning

confidence: 99%

A review: Development of magnetic nano vectors for biomedical applications

Nosheen¹,

Irfan²,

Abidi³

et al. 2021

GSC Adv. Res. Rev.

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The study of magnetic nanoparticles (MNPs) is an emergent field of science in this era due to their widespread utilization in the various fields of biomedical science. Developing concerns of magnetic nanoparticles in the researcher’s field led to design a huge number of MNPs including individual or binary metallic particles, oxides, (ferrites), biopolymer coated composites, metallic carbides and graphene mediated nanoparticles. Numerous synthetic routes are defined in literature to attain the desired size, crystal structure, morphology and magnetic properties. To build up biocompatibility, MNPs subjected to surface treatments by coating with some suitable organic or inorganic biomaterials which not only improves its physical characteristics but also elevate its chemical stability. These biomaterials coat either isolatly or in a combined state to enhance the colloidal stability, magnetic properties as well as prevent it cytotoxicity and surface corrosion in the biological media. These properties are essential for the particles and empowering their effectiveness in various biomedical science i.e., drug delivery Magnetic resonance imaging (MRI), hyperthermia, biosensors and gene therapy etc. Current review recapitulates the verdicts of previous research on the subject of magnetic nanoparticles. It will also explain the recent advancements of biomaterials that execute a dynamic role in various medical treatments. Our main focus is to report the particle types, design and properties as well as discussing various synthetic routes including sol gel, co-precipitation, microemulsion, green synthesis, sonochemical method and polyol synthesis etc. These methods produced particles of excellent yield with unique magnetic properties, coercivity and crystallinity and enhanced biocompatibility as compared to traditional methods used to develop MNPs.

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“…Plasmin-sensitive protein interacts with IgG-MNPs and anti-PI-antibody-AuNP-oligonucleotides to form sandwich complex. Magnetic field is used to isolate complex and the oligonucleotides are quantified in the form of magnitude of reduction peak current using square wave voltammetry [ 87 ]. Interaction of domain 4 protective antigen of Bacillus anthracis with gel green–labeled aptamer-MWCNTs induces decrease in fluorescence intensity [ 93 ].…”

Section: Detection Of Gmo Mutated and Resistant Organismsmentioning

confidence: 99%