Participation in sport and physical activity in head and neck cancer survivors: associations with quality of life

Sammut, Luke; Fraser, Lisa; Ward, Matthew J.; Singh, Tahwinder; Patel, Nimesh

doi:10.1111/coa.12506

Cited by 16 publications

(30 citation statements)

References 40 publications

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“…Smoking, alcohol consumption and infection with the human papillomavirus (HPV) are the most common risk factors for developing HNC [2]. Observational studies showed that higher levels of physical activity following the diagnosis and treatment of cancer and higher levels of physical fitness before the diagnosis of cancer are associated with reduced mortality [2][3][4] and better quality of life [5], but the relationship is not uniform, may differ by the type of cancer. Based on these studies, it seems clear that levels of physical activity and fitness play an important role in the risk of cancer, the quality of life of patients with cancer and mortality in patients with cancer.…”

Section: Introductionmentioning

confidence: 99%

“…Physical activity is a behavior that includes occupational, leisure, household or other activities, whereas health-related physical fitness is a set of attributes that people have or achieve and which includes cardiorespiratory fitness and muscle strength [6]. Previous retrospective studies showed that 31% of patients with HNC met the current physical activity guideline pre-diagnosis, which decreased to 8.5% after diagnosis [7] and declines further during treatment [5,8,9]. However, all these studies measured physical activity through self-report, which is prone to bias [10] and likely to over-or underreport physical activity levels [11].…”

Section: Introductionmentioning

confidence: 99%

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Demographic, clinical and lifestyle-related correlates of accelerometer assessed physical activity and fitness in newly diagnosed patients with head and neck cancer

et al. 2019

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Introduction: Objective measurements of levels of physical activity and fitness in patients with head and neck cancer (HNC) are lacking. Furthermore, demographic, clinical and lifestyle-related correlates of low levels of physical activity and fitness in patients with HNC are unknown. This study aims to investigate the levels of accelerometer that assessed physical activity and fitness in patients with HNC and to identify their demographical, clinical and lifestyle-related correlates. Methods: Two hundred and fifty-four patients who were recently diagnosed with HNC and participated in the NETherlands QUality of life and Biomedical cohort studies In head and neck Cancer (NET-QUBIC) study were included. Physical activity (accelerometer), cardiorespiratory fitness (Chester Step Test), hand grip strength (hand dynamometer) and lower body muscle function (30-second chair-stand test) were assessed. Multivariable linear regression analyses with a stepwise forward selection procedure were used. Results: Patients spent 229 min/d in physical activity of which 18 min/d in moderate-to-vigorous physical activity. The mean predicted VO 2 max was 27.9 ml/kg/min, the mean hand grip strength was 38.1 kg and the mean number of standings was 14.3. Patients with lower educational level, more comorbidity and higher tumor stage spent significantly less time in physical activity. Older patients, females and patients with a higher tumor stage had significantly lower cardiorespiratory fitness levels. Older patients, females, patients with more comorbidity, patients with normal weight and patients who have never smoked had significantly lower hand grip strength. Older patients, patients with lower educational level, smokers and patients with more comorbidity had a significantly lower function of lower body muscle. Conclusions: Pre-treatment levels of physical activity, cardiorespiratory fitness and lower body muscle function are low in patients with HNC. Based on this study, exercise programs targeted and tailored to patients with low levels of physical activity and fitness can be developed.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Demographic, clinical and lifestyle-related correlates of accelerometer assessed physical activity and fitness in newly diagnosed patients with head and neck cancer

et al. 2019

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“…Other studies have also reported decreases in physical function and QOL after HSCT, compared to pre‐transplantation levels, in patients having undergone allo‐HSCT (Takekiyo et al., ; Wiskemann et al., ). Although the relationship between physical activity and QOL has been evaluated in patients with breast cancer (Pakiz et al., ), gastrointestinal cancer (Jensen et al., ), ovarian cancer (von Gruenigen et al., ), prostate cancer with radical prostatectomy (Santa Mina et al., ), lung cancer (Wang et al., ), head and neck cancer (Sammut, Fraser, Ward, Singh, & Patel, ), colorectal cancer (Grimmett, Bridgewater, Steptoe, & Wardle, ), and kidney cancer (Trinh, Plotnikoff, Rhodes, North, & Courneya, ), the relationship of physical activity with physical function and health‐related QOL in patients having undergone allo‐HSCT remains to be evaluated. Therefore, we investigated the differences in the intensity levels of physical activity, physical function, and health‐related QOL before and after transplantation.…”

Section: Introductionmentioning

confidence: 99%

Relationship of physical activity with physical function and health-related quality of life in patients having undergone allogeneic haematopoietic stem-cell transplantation

et al. 2017

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In this study, we investigated the differences in physical activity before and after transplantation, and the relationship between physical activity and physical function and health-related quality of life (QOL) in 30 patients who underwent allogeneic haematopoietic stem cell transplantation (allo-HSCT). Duration and intensity of physical activity were quantified using a three-dimensional accelerometer. Physical function was quantified by handgrip and knee-extensor strength, with the 6-minute walk test (6MWT) used as a measure of exercise capacity. Health-related QOL was assessed using the 36-item Short-Form Health Survey. The proportion of daily activities performed at an intensity >3.0 metabolic equivalents (METs) increased significantly after allo-HSCT (p < .05). Daily activity time performed at an intensity of 1.6-2.9 METs significantly correlated only with left knee strength (p < .05). In contrast, the total number of daily steps and the proportion of activity performed at 1.6-2.9 METs and >3.0 METs were positively correlated with the 6MWT (p < .05). Additionally, physical functioning and general health subscales in health-related QOL positively correlated with daily activities performed at >3.0 METs (p < .05). Physical activity was associated with 6MWT and health-related QOL. These findings have implications for rehabilitation planning for patients undergoing allo-HSCT.

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“…Observational studies showed that higher levels of moderate-to-vigorous PA are associated with lower mortality risk in survivors of breast, colon, and prostate cancer [ 19 , 21 , 25 , 30 , 38 ]. Also in HNC survivors, higher pre-treatment levels of PA and physical function were found to be associated with higher HRQoL [ 6 , 36 ] and survival [ 10 , 43 ].…”

Section: Introductionmentioning

confidence: 99%

Patient-reported physical activity and the association with health-related quality of life in head and neck cancer survivors

Nieuwenhuizen

Buffart

Uden–Kraan

et al. 2017

Support Care Cancer

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PurposeThis study aimed to assess patient-reported levels of physical activity (PA) and its associations with health-related quality of life (HRQoL) adjusted for important demographic, lifestyle-related, and clinical factors, among head and neck (HNC) survivors.MethodsThis cross-sectional study included 116 HNC survivors. PA was assessed with the Physical Activity Scale for the Elderly (PASE) and HRQoL with the EORTC-QLQ-C30 and EORTC-HN35. Associations were studied using univariable and multivariable regression analyses.ResultsMedian PASE score was 100.3 (interquartile range 65.1;170.8) of which 54% were household, 34% leisure-time, and 12% occupational activities. Younger HNC survivors had higher levels of PA. Higher PA was significantly associated with higher global QoL (p < 0.05). Findings for physical function, role function, social function, fatigue, and pain were in line, but not statistically significant (0.05 ≤ p < 0.10).ConclusionsAmong HNC survivors, a large proportion of PA consists of household activities. Younger HNC survivors had higher PA levels, and higher PA levels were associated with higher HRQoL.

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Participation in sport and physical activity in head and neck cancer survivors: associations with quality of life

Abstract: These data suggest that PA may improve QOL following treatment for HNC. We believe that further studies are warranted.

Cited by 16 publications

References 40 publications

Demographic, clinical and lifestyle-related correlates of accelerometer assessed physical activity and fitness in newly diagnosed patients with head and neck cancer

Demographic, clinical and lifestyle-related correlates of accelerometer assessed physical activity and fitness in newly diagnosed patients with head and neck cancer

Relationship of physical activity with physical function and health-related quality of life in patients having undergone allogeneic haematopoietic stem-cell transplantation

Patient-reported physical activity and the association with health-related quality of life in head and neck cancer survivors

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